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9 articles for “Cytokine Release”
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Research ArticleOpen accessPhrase in the titleT-2 Toxin Regulated Ganoderma lucidum Induced Cytokine ReleaseKazem Ahmadi, Majid RiazipourThe water-soluble extract of Ganoderma lucidum (Reishi) has been used as immunomodulator to stimulate spleen cells proliferation and cytokine expression. It has also been shown that at some level of exposure, T-2 toxin typically act as immunosuppressive agent and can increase disease susceptibility. The aim of this study was to investigate the effect of T-2 toxin on cytokine production by … …American Journal of Immunology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,538 accessesView PDFCite
Research ArticleOpen accessIn the keywordsModeling Hepatocellular Toxicity of Enavatuzumab, a Humanized Anti-TweakR AntibodyDonghee Choi, Yanhong Zhu, Debra Tien Chao et al.In a Phase 1 clinical study, treatment with enavatuzumab, a humanized monoclonal antibody to TweakR, resulted in liver toxicity in a subset of patients. The objective of this current study was to evaluate the ability of preclinical studies to predict liver toxicity in humans. Enavatuzumab was evaluated in cynomolgus monkeys, where serum liver enzyme and cytokine levels were measured and … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 2 · 9 Nov 2017 · 7,719 accessesView PDFCite
Literature ReviewOpen accessIn the abstractFundamental Questions about γδT CellsMoulay Yassine Belghali, Saadia Ba-M’hamed, Mouna Khouchani, Brahim AdmouγδT cells is a minor subgroup of T lymphocytes expressing γδ-T Cell Receptor (TCR), with many subsets, dominated by Vδ2 and Vδ1. γδT cells recognize antigens independently of the context of MHC class I, MHC class II, or CD1 presenting molecules. However, this recognition requires the expression of the transmembrane Butyrophilin proteins by the presenting cells. Their activation is controlled … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 15 Dec 2020 · 6,382 accessesView PDFCite
Research ArticleOpen accessIn the abstractDoes Iron Modulate Cytokine Production by Desferrioxamine Treated Mononuclear Cells?Hanna Bessler, Meir DjaldettiIron is an essential element for maintaining the normal function of cellular and multicellular organisms and it is closely associated with inflammation and immunity. Macrophages and lymphocytes play an important role in its homeostasis. Hereby we have evaluated cytokine production by iron depleted and iron supplemented human peripheral blood mononuclear cells (PBMC) from healthy adult donors. Non-stimulated or stimulated PBMC … …OnLine Journal of Biological Sciences, Vol. 18, Issue 1 · 7 Jan 2018 · 6,845 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe -863 TNF-α Polymorphism and Primary Open Angle Glaucoma in EgyptiansWalaa Bayoumie Abdulwahhab El Gazzar, Shaymaa Mohamed Abd El Rahman, Mohamed Nagy Elmohamady et al.Growing evidence indicates that TNF-alpha is involved in the pathogenesis of POAG in several ways, primarly by induction of retinal ganglion cells apoptosis and therefore optic nerve degeneration. TNF-alpha and POAG relationship has been studied at the genetic level with variable results in different populations. The transcription rate and the release of the TNF-alpha cytokine have been reported to be … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 1 Jun 2017 · 7,356 accessesView PDFCite
Research ArticleOpen accessIn the abstractEFFECT OF ZINC OXIDE NANOPARTICLES ON NEUROBLASTOMA SH-SY5Y CELLSJinghui Zheng, Theresia Schnurr, Kriya Dunlap et al.The Arctic and sub-arctic regions are impacted by the growth of the global nanotechnology industry and the transport of chemicals to the North. New nanotechnology industries, such as neural prothesis, are bringing nanomaterials in direct contact with neurons and glial cells. Nanomaterials have unique chemical and physical properties that may lead to toxicological effects by interfering with normal cellular metabolism. … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 2 · 4 Jul 2014 · 8,488 accessesView PDFCite
Research ArticleOpen accessIn the abstractDengue Virus Infection Induced NF-κB-dependent Macrophage Migration Inhibitory Factor ProductionLien-Cheng Chen, Huey-Wen Shyu, Huan-Yao Lei et al.Dengue virus (DV) infection can cause mild dengue fever or severe dengue hemorrhage fever and dengue shock syndrome. Macrophage migration inhibitory factor (MIF) is a cytokine that plays an important role in the modulation of inflammatory and immune responses and serum levels of MIF are correlated with disease severity in dengue patients. However, the mechanism that induces MIF production during … …American Journal of Infectious Diseases, Vol. 4, Issue 1 · 31 Mar 2008 · 7,290 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of Cytokines in the Regulation of Glioma Tumour Growth and AngiogenesisChristina Piperi, Athanasios Zisakis, Robert W. Lea, Anastasios KalofoutisMalignant glioblastomas are the most common type of primary brain tumors accounting for more than 50% of all intracranial gliomas. Due to their aggressive nature, recurrent growth, and their extremely poor prognosis for survival, research approaches have made little progress in advancing treatment of these tumours which have the ability of both modulating host immune function and neutralizing immune-based therapies. … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,868 accessesView PDFCite
Research ArticleOpen accessIn the abstractNitric Oxide Donors with Therapeutic Strategic in Experimental Schistossomiasis MansoniWander Rogério Pavanelli, Jean Jerley Nogueira da Silva, Carolina Panis et al.Schistosomiasis, an immune disease, remains a major public health problem in endemic area. To determine the influence of Nitric Oxide (NO) on this disease, we tested two compounds (Trans-[Ru(bpy)2(NO)SO3](PF6)-PF6 and Na2[Fe(CN)5(NO)]-SNP, which releases NO when activated by biological reducing agents, in BALB/c mice infected subcutaneously by Schistosoma BH strains. The parasitic activity of NO-donors was evaluated in this model by … …American Journal of Immunology, Vol. 10, Issue 4 · 24 Feb 2015 · 7,851 accessesView PDFCite