2 articles for “Clozapine”

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Research ArticleOpen accessEvery word in the titleClozapine and its Major Stable Metabolites, N-desmethylclozapine and Clozapine N-oxide do not Affect Human Bone Marrow Stromal Cells in vitroAvril Pereira, Brian DeanTreatment of refractory schizophrenia with the atypical antipsychotic drug clozapine is associated with life-threatening agranulocytosis, characterised by a drop in neutrophil count. Theoretically, toxicity may be accounted for by direct action of parent drug or one of its stable metabolites on bone marrow stroma given importance of these cells to neutrophil maturation. Effects of clozapine, N-desmethylclozapine and clozapine N-oxide on … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 7,109 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsWeighted Kernel Density Estimation of the Prepulse Inhibition TestHongbo Zhou, Qiang Cheng, Hong-Ju Yang, Haiyun XuProblem statement: The goal of this study was to devise a more reliable and sensitive method for analysis of experimental data of the Prepulse Inhibition (PPI), the reduction in startle reaction towards a startle-eliciting “pulse” stimulus when it is shortly preceded by a sub-threshold “prepulse” stimulus. Approach: Different from the conventional simple averaging-based method, we proposed a probabilistic approach to … …Journal of Computer Science, Vol. 7, Issue 5 · 7 May 2011 · 7,222 accessesView PDF Cite