Research NotesOpen accessIn the keywordsNuciferine Attenuates Cigarette Smoke-Induced Senescence in HepG-2 Cells via the miR-217/SIRT1/Nrf2 PathwayYun-Hong Zhao, Yi-Meng Ge, Wei-Jia Xu et al.The lotus leaf, widely used in both medicine and cuisine, contains bioactive compounds with therapeutic potential. Nuciferine (NF), an active constituent of significant importance, is extracted from the lotus leaf. The present study sought to uncover the molecular pathways through which Nuciferine (NF) mitigates cellular senescence triggered by Cigarette Smoke Components (CSCs) in HepG-2 cells, employing an experimental model where … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 4 Oct 2025 · 2,296 accessesView PDFCite