5 articles for “Cardiotoxicity”

Set a search alert

Research ArticleOpen accessEvery word in the titleCardioprotective Effect of Lagenaria siceraria (Molina) Standley (Cucurbitaceae) Fruit Juice on Doxorubicin Induced Cardiotoxicity in RatsM. Hassanpour Fard, G. Naseh, S. L. Bodhankar, M. DikshitProblem statement: The cardio toxicity of Doxorubicin (Dox) has limited its use as an anticancer drug. The aim of present study was to investigate the cardio protective effect of Lagenaria Siceraria (Cucurbitaceous) Fruit Juice (LSFJ) against the cardio toxicity of Dox in rats. Approach: Male wistar rats (250-300 g) were randomly divided into four groups. Group I- was control, Group … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,510 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsToxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)Diallo Aboudoulatif, Dowou Salem, Badjabaissi Essotolom et al.Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and sub-chronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 16 Mar 2020 · 7,755 accessesView PDF Cite

Review ArticleOpen accessIn the abstractSARS-CoV-2-Induced Damage on the Cardiovascular System: Molecular MechanismsMel·lina Pinsach-Abuin, Ramon Brugada TerradellasSince its emergence in late December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the causative agent of coronavirus disease 2019 (COVID-19) - has spread rapidly world-wide, becoming a global pandemic in March 2020 that is still active. In addition to the severe pulmonary damage, clinical studies have reported that COVID-19 is associated with the development of cardiovascular … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 25 Nov 2021 · 6,791 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAntiretroviral Toxicity and Oxidative StressAdikwu Elias, Brambaifa Nelson, Deo Oputiri, Oru-Bo Precious GeoffreyAntiretroviral drugs are used for the treatment of human immunodeficiency virus, they are used as combination regimens to achieve the highest possible benefit, tolerability, compliance and to diminish the risk of resistance development. Reports from preclinical and clinical studies have linked antiretrovirals with some toxicological effects which could be associated with redox imbalance (oxidative stress). This stimulated us to review … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 20 Nov 2013 · 8,255 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In RatKaneez F. Shad, Suhail Al-Salam, Alaaeldin A. HamzaThe therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,670 accessesView PDF Cite