Research ArticleOpen accessEvery word in the titleComposite Scaffolds for Bone Tissue EngineeringMin WangBiomaterial and scaffold development underpins the advancement of tissue engineering. Traditional scaffolds based on biodegradable polymers such as poly(lactic acid) and poly(lactic acid-co-glycolic acid) are weak and non-osteoconductive. For bone tissue engineering, polymer-based composite scaffolds containing bioceramics such as hydroxyapatite can be produced and used. The bioceramics can be either incorporated in the scaffolds as a dispersed secondary phase or … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,355 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGrowth of Bone Marrow Derived Osteoblast-Like Cells into Coral Implant Scaffold: Preliminary Study on Malaysian CoralK. A. AL-SalihiProblem statement: Biomaterial fabrication in Malaysia started as a consequence of the demand for cheaper implant materials. Various biomaterials have been developed utilizing local resources like Malaysian coral. Locally processed Malaysian coral need to be complemented with proper evaluation and testing including toxicology, biocompatibility, mechanical properties, physicochemical characterization and in vivo testing. The present study was carried out to assess … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 6,590 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFabrication of 3-D Porous Mg/Zn doped Tricalcium Phosphate Bone-Scaffolds via the Fused Deposition ModellingSamar Jyoti Kalita, Melissa FergusonThree dimensionally interconnected porous resorbable beta-tricalcium phosphate (β-TCP) ceramic scaffolds were developed using the indirect fused deposition modelling process. β-TCP was doped with Mg and Zn, separately, to improve its sintering kinetics and facilitate fabrication of viable porous scaffolds. Effects of Mg and Zn on sintering kinetics and densification of β-TCP were studied. Fabricated porous scaffolds were tested for their … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,926 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDevelopment of Cell-Responsive Nanophase Hydroxyapatite for Tissue EngineeringR. Murugan, S. RamakrishnaScaffold plays a critical role in engineering bone tissues by providing necessary structural support for the cells to accommodate and guiding their growth in the three dimensional (3D) space. Therefore, designing scaffold that mimic composition and structural aspects of the bone is of great importance to promote cell adhesion, cell-matrix interactions, osteointegration, tissue formation and continued function. Nanophase hydroxyapatite (HA) … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 3 · 30 Sep 2007 · 7,163 accessesView PDFCite
Research ArticleOpen accessIn the keywordsBioceramics for Tissue Engineering Applications-A ReviewSunho Oh, Namsik Oh, Mark Appleford, Joo L. OngThree dimensional (3-D) scaffolds have been explored in an attempt to persuade the body to heal or repair tissues that do not do so spontaneously. Considerable advances in tissue engineering and regeneration have been accomplished over the last decade. However, the material and 3-D scaffolds ideal for optimal regeneration of missing or lost tissues has not been identified. While current … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 10,420 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Optimization of a Porous Ti6Al4V Bone Construct Using Additive ManufacturingJeffrey Wilk, Glenn Sanders, Shelby Marks et al.Patient specific implants are becoming viable treatment options in some orthopaedic applications through advances in additive manufacturing and 3D printing techniques. One potential application is for treatment of segmental bone defects, particularly in patients suffering from bone cancer. Current treatment options are: Amputation, megaprosthesis, or allografts. These treatments are often highly invasive, may require a partial/full joint replacement and are … …American Journal of Engineering and Applied Sciences, Vol. 10, Issue 1 · 2 Jan 2017 · 7,811 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Process of Porous Tantalum Implants Osseous Integration a ReviewChristos G. Paganias, George A. Tsakotos, Stephanos D. Koutsostathis, George A. MacherasPorous tantalum is a biomaterial that was recently introduced in orthopaedics in order to overcome problems of the past related to implant loosening. Its use has led to very good results, especially in difficult cases where severe bone defect is present, as it is found to have osteoconductive and possibly, osteoinductive properties. So, it is of great interest to shed … …Current Research in Medicine, Vol. 5, Issue 2 · 22 Apr 2015 · 7,847 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanically Stimulated Osteoblast Cells GrowthRaffaella Aversa, Antonio Apicella, Francesco Tamburrino, Florian Ion Tiberiu PetrescuThe bones need to be built and then permanently restored to keep them functioning properly. Considering the multiple bone functions, their vitality is essential both to maintain the body and move it and to maintain its health and vigor. When most bones begin to age and have no vital function, the man also begins to age, lose water, minerals, electrolytes, … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 19 Jun 2018 · 7,882 accessesView PDFCite
Research ArticleOpen accessIn the abstractHybrid Ceramo-Polymeric Nano-Diamond CompositesAntonio Apicella, Raffaella Aversa, Florian Ion Tiberiu PetrescuThis paper discusses a new class of bio-mechanical scaffolds active for tissue engineering based on a nano-diamond-filled hydrophilic polymer matrix. The new biomaterials used have special mechanical and biological properties for which they should be extensively studied for their use for various advanced biomedical applications. The new hybrid material has been prepared using 2 and 5% by volume of detonating … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 21 May 2018 · 8,616 accessesView PDFCite
Research ArticleOpen accessIn the abstractHybrid Ceramo-Polymeric Nanocomposite for Biomimetic Scaffolds Design and PreparationRaffaella Aversa, Relly Victoria V. Petrescu, Roberto Sorrentino et al.Biomimetics, biomechanics and tissue engineering are three multidisciplinary fields that have been contemplated in this research to attain the objective of improving prosthetic implants reliability. Since testing and mathematical methods are closely interlaced, a promising approach seemed to be the combination of in vitro and in vivo experiments with computer simulations (in silico). An innovative biomimetics and biomechanics approach and … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 30 Nov 2016 · 8,269 accessesView PDFCite