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31 articles for “Arthritis”
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Review ArticleOpen accessEvery word in the titleJAK Inhibitors for Rheumatoid Arthritis: Assessing Efficacy and Safety in TreatmentAnastasia V. Poznyak, Varvara A Orekhova, Natalia Vladimirovna Elizova et al.Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation, progressive joint destruction, and systemic complications. Dysregulated cytokine signaling through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway plays a central role in RA pathogenesis, making JAK inhibitors an important therapeutic option. Tofacitinib, baricitinib, and upadacitinib are oral targeted synthetic disease-modifying antirheumatic drugs that interfere with … …OnLine Journal of Biological Sciences, Vol. 26, Issue 4 · 8 Oct 2026 · 412 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHigh-Order Interactions in Rheumatoid Arthritis Detected by Bayesian Method using Genome-Wide Association Studies DataJing Zhang, Zheyang Wu, Chao Gao, Michael Q. ZhangProblem statement: In order to reveal the missing genetic component of Rheumatoid Arthritis (RA) susceptibility, we carried out a genome-wide high-order epistatic interaction study for RA. Approach: A powerful Bayesian strategy was applied to analyze the data of Genome-Wide Association Studies (GWAS) from the Welcome Trust Case Control Consortium (WTCCC), where 319 high-order interactions were found across the whole genome … …Current Research in Medicine, Vol. 3, Issue 1 · 30 Mar 2012 · 8,379 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effect of Antioxidants Supplement on Lipid Peroxidation and Serum Aryl Esterase Enzyme in Rheumatoid Arthritis PatientsMahsa Jalili, Seyed-Rafi Aref-Hosseini, Sousan Kolahi et al.Problem statement: Rheumatoid Arthritis (RA) is one of the common autoimmune diseases with unknown etiology that its prevalence ratio in females to males is 3:1. It has been suggested that serum antioxidant levels is reduced and lipid peroxidation is increased due to oxidative stress. According to a recent research, antioxidant supplements may play an important role in controlling oxidative stress. … …Current Research in Medicine, Vol. 2, Issue 2 · 2 Dec 2011 · 7,038 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnti-Inflammatory Activity of Vitex leucoxylon L. Bark Extracts Against Freund's Complete Adjuvant Induced Arthritis in Sprague Dawley RatAlluri V. Krishnaraju, Chundi B.M. Rao, Dodda Sundararaju et al.Problem statement: Anti-inflammatory agents, particularly steroids and cyclooxygenase inhibitors are often associated with adverse side effects including, GI irritation, ulcers, hypertension and cardiac abnormalities. A safe and effective intervention is essential for the treatment of inflammatory disorders. Approach: Abstract Vitex leucoxylon L., a medicinal plant of the verbenaceae family, used in traditional medicine for relieving headache and catarrh. VL-89/185A, was … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,044 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleBotulinum Toxin as a Novel Addition to Anti-Arthritis ArmamentariumHamid Namazi, Zahra MajdOsteoarthritis is the most common joint disease and is among the most frequent health problems for middle aged and older people. There is strong evidence that proinflammatory cytokines contribute to cartilage degradation in osteoarthritis. Interleukin-1 is the prototypical proinflammatory cytokine implicated in the pathogenesis of cartilage matrix degeneration. Results from studies in animal models provide stronger evidence implicating a role … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,775 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCombination of Serological Tests (Anti-CCP Antibody, Rheumatoid Factor IgM ELISA and Latex Test) are more Useful in Detection of Rheumatoid ArthritisAnindya Das, Chimanjita Phukan, Chitralekha BaruahRheumatoid arthritis is a polyarticular and chronic inflammatory disease occurring throughout the world. To prevent significant joint damage, early diagnosis and proper treatment is of paramount importance. Though patients are diagnosed clinically supported by radiography and serological tests, early disease may present with non-specific arthritis and absence of specific radiographic findings. Though anti-CCP antibody is used for the diagnosis and … …American Journal of Immunology, Vol. 13, Issue 3 · 23 Sep 2017 · 7,389 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStress Analysis of an Artificial Human Elbow Joint: Application of Finite Element AnalysisStephen K. ArmahThe elbow joint is frequently affected by two kinds of arthritis (degenerative arthritis and rheumatoid arthritis) following some kind of injuries. There have been efforts since the eighteenth century by various individuals and organizations in modeling permanent implants for the elbow joint, but some of the prostheses have been disappointing because of lack of understanding of the biomechanics of the … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 1 · 4 Jan 2018 · 9,533 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEVALUATION OF THE ANTI-ARTHRITIC EFFECT OF STERCULIA TRAGACANTHA (LINDL.) LEAF EXTRACT IN RATSUdegbunam Rita Ijeoma, Nwaehujor Chinaka Onyebuchi, Udegbunam Sunday OsitadimmaSterculia tragacantha leaves for years have been used by traditional healers in eastern Nigeria in the treatment of arthritis, edema, gout, whitlow and cold. The aim of this study was to evaluate the folkloric claims of Sterculia tragacantha leaf extract in relieving arthritic conditions. The effects of Sterculia Tragacantha methanol leaf Extract (STEX) on formaldehyde and adjuvant-induced arthritis were studied … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 2 · 11 Mar 2014 · 7,588 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRat Model for Poly-AutoimmunityMaria StaykovaAround 30% of the male PVG rats have very low testosterone levels. Upon immunisation with myelin basic protein in complete Freund’s adjuvant they develop experimental autoimmune encephalomyelitis and adjuvant arthritis. The androgen insensitive syndrome in these rats could be used in studies on poly-autoimmunity as well as in studies on variations in the sexual differentiation of brain and behavior. …American Journal of Immunology, Vol. 8, Issue 3 · 7 Sep 2012 · 7,549 accessesView PDFCite
Research ArticleOpen accessIn the keywordsBayesian Determination of Disease Associated Differences in Haplotype BlocksIvan Kozyryev, Jing ZhangProblem statement: While experimental ascertainment of haplotype blocks in the genome-scale case-control studies is expensive, accurate computational phasing is still a daunting task for bioinformatics approaches. We used a statistical method to determine differences, potentially associated with a certain disease, in linkage disequilibrium block boundaries in whole-genome Single Nucleotide Polymorphisms (SNPs) data. Approach: We utilized a Bayesian model for calculating … …Current Research in Bioinformatics, Vol. 1, Issue 1 · 14 Feb 2012 · 8,423 accessesView PDFCite