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3 articles for “Antileishmanial”
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Research ArticleOpen accessEvery word in the titleAntileishmanial and Antibacterial Activity of Essential Oils of Medicinal Plant Achillea santolina L.Abdulkarim Dakah, Mohammed MaarroufAchillea santolina is medicinal plant widely used in folk medicine for gastrointestinal disorders, anti-inflammatory and anti-diuretic. The World Health Organization (WHO) reports that about 350 million people are considered to be at risk of contracting leishmaniasis especially among people living in the developing countries. This research will be the first time that evaluate antileishmanial activity of essential oils of A. … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 2 Mar 2019 · 9,199 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,893 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModeling and Molecular Docking Studies on Rnase Aspergillus niger and Leishmania donovani Actin: Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Kirti Shila Sonkar et al.A.niger Rnase was designed from ACTBIND (PDB ID: 3D3Z). Yeast actin-human gelsolin segment 1 complex (PDB ID: 1YAG) was used as template for L. donovani actin protein for 3D model in Modeller9v8. These models were testified by PROCHECK, ERRAT, WHAT-IF, PROSA2003 and VERIFY-3D. All evidences suggest that the geometric quality of the backbone conformation, energy profile, residue interaction and contact … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,527 accessesView PDFCite