3 articles for “Antiemetic”

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Research ArticleOpen accessEvery word in the titleTheoretical Investigation of Two Antiemetic Drugs at DFT LevelKhalil Errahmane Kanouni, Yacine BenguerbaThe geometries and the bonding properties have been predicted for two antiemetic drugs using Density Functional Theory method (DFT). Mulliken population and frontier molecular orbital analysis with the determination of the physicochemical properties was performed using the Amsterdam Density Functional package (ADF). To calculate the exchange-correlation energy, the Generalized Gradient Approximation of Becke-Perdew (GGA-BP) was used. The most important finding … …Current Research in Bioinformatics, Vol. 9, Issue 1 · 14 May 2020 · 11,496 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleThe Development of New Molecules Having Antiemetic Activity Using Molecular ModelingKhalil Errahmane Kanouni, Yacine BenguerbaThe solubility of a drug in water or in the blood represents the most desired parameter in medicine. Our aim is to obtain molecules with properties more effective than those of metoclopramide. In this work, two molecules with high solubility are constructed. Metoclopramide (a benzamide derivative) is a dopamine receptor antagonist used as an antiemetic drug. Its solubility in water … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,664 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMirtazapine in Veterinary Medicine a Pharmacological Rationale for its Application in Chronic PainMario Giorgi, Helen OwenProblem statement: Many recent studies have shown that antidepressant agents have analgesic effects in addition to their intended primary actions. The Tricyclic Antidepressants (TCAs) have been recognized as an effective first-line treatment of human neuropathic pain but unfortunately they display a wide range of side effects. Recent studies have shown that Selective Serotonin Reuptake Inhibitors (SSRI) also have potential analgesic … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 19 May 2012 · 8,189 accessesView PDF Cite