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30 articles for “Acetylcholine”
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Research ArticleOpen accessEvery word in the titleQSAR Modeling of Thirty Active Compounds for the Inhibition of the Acetylcholinesterase EnzymeNour El Houda Hammoudi, Yacine Benguerba, Widad SobhiThis work aims at developing a reliable and predictive QSAR model which allows, on one hand, an exploration of the main molecular descriptors responsible for the inhibitory activity towards the Acetylcholinesterase enzyme and, on the other hand, predict the inhibitory activity of new compounds before testing them experimentally. This study involves a series of DL0410 and its 29 DL0410 derivatives. … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 2 Mar 2020 · 11,426 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleMolecular Docking of New Active Compounds Towards the Acetylcholinesterase EnzymeLemaoui Tarek, Hammoudi Nour El Houda, Benguerba Yacine, Attoui AyoubMolecular docking is a key instrument in structural molecular biology and computer-assisted drug design. The objective of ligand-protein docking is to expect the main binding mode(s) of a ligand with a protein of known three-dimensional structure. Effective docking methods search high-dimensional spaces effectively and finding a scoring function that correctly ranks candidate dockings (Morris et al., 2008). In this study … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 11,404 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNasal Administration of Quercetin Liposomes Modulate Cognitive Impairment and Inhibit Acetylcholinesterase Activity in HippocampusTerdthai Tong-Un, Supaporn Muchimapura, Wathita Phachonpai, Jintanaporn WattanathornProblem statement: Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer’s Disease (AD). Several reports have indicated that antioxidant intake is beneficial to delay or inhibit the progression of this disease. Presently, Acetylcholinesterase (AChE) inhibitors are the mainstay of therapy for AD. Quercetin, one of the flavonoids in fruits and vegetables, has a powerful … …Neuroscience International, Vol. 1, Issue 1 · 30 Jun 2010 · 7,170 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInvestigation of Biochemical and Hormonal Parameters in Male Patients with MigraineDua’a AlHassoon, Omar Atrooz, Husni FarahMigraine is a complex neurological disorder, including hormonal and biochemical imbalances. The physiological changes include neural variations due to genetic, environmental, and lifestyle factors. Therefore, the research aims to investigate total testosterone levels, Acetylcholine (Ach), prolactin, and clinical markers (calcium, magnesium, glucose, and lipid profile) across migraine patients. The research employed a case-control observational design conducted at Al-Ahliyya Amman University, … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 22 Jul 2026 · 815 accessesView PDFCite
Research ArticleOpen accessIn the keywordsGastroprotective Effect and Safety Assessment of Zanthoxylum Zanthoxyloides (Lam) Waterm Root Bark ExtractAlex Boye, George Asumeng Koffuor, Johnson Nyarko Boampong et al.Problem statement: Gastrointestinal ulcers account significantly for morbidity and mortality in Ghana. The study therefore investigated the gastroprotective effect of an ethanolic root bark extract of Zanthoxylum zanthxyloides and its safety for us. Approach: Gastric ulceration was induced in Sprague-Dawley rats with Indomethacin (25 mg kg-1, p.o) and was treated with 150, 250, or 500 mg kg-1 of the extract, … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 7 Aug 2012 · 8,495 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAqueous Extracts of Bay Leaf (Laurus nobilis) and Rosemary (Rosmarinus officinalis) Inhibit Iron-Induced Lipid Peroxidation and Key-Enzymes Implicated in Alzheimer’s Disease in Rat Brain-in VitroAyodeji O. Falade, Goodness I. Omolaiye, Kayode E. Adewole et al.Neurological disorders remain a global health challenge, with Alzheimer’s Disease (AD) as the most famous cause of dementia in old people. Nevertheless, culinary spices and herbs have shown promising potentials in the management of neurological diseases. This study aimed at investigating the neuroprotective property of aqueous extracts of bay leaf (Laurus nobilis) and rosemary (Rosmarinus officinalis) by assessing the antioxidant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 25 Jan 2022 · 7,955 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAssessment of Neuropharmacological Activities of Terminalia Chebula in RatsWathita Phachonpai, Jintanaporn Wattanathorn, Terdthai Tong-un et al.Problem statement: Oxidative stress has been implicated in the pathophysiology of many neurodegenerative diseases such as Alzheimer’s Disease (AD). In traditional practices of Ayurvedic medicine, numerous herbs have been used to treat cognitive disorders. Terminalia Chebula (Combretaceae; TC), is a well-known Ayurvedic herbal remedy which possesses an antioxidant activity. The scientific literature strongly supports its in vitro exerted acetylcholinesterase inhibitory … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 11 Jun 2012 · 8,295 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMulberry Fruit Mitigates Alcohol Neurotoxicity and Memory Impairment Induced by Chronic Alcohol IntakeJintanaporn Wattanathorn, Nattaporn Phunchago, Supaporn Muchimapura et al.Problem statement: To date, the therapeutic strategy efficacy against memory impairment induced by alcohol intoxication is still limited. The novel therapeutic strategy which is easy to approach, less toxic and less cost is required. Based on the role of oxidative stress in memory impairment induced by alcohol, the neuroprotective effect of substance possessing antioxidant has gained much attention. Therefore, we … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 8 Feb 2012 · 9,328 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCoronary Endothelial Dysfunction after Drug-Eluting Stent ImplantationShigenori ItoProblem statement: Stent thrombosis, which may occur even one year after stent implantation, is a drawback of Drug-Eluting Stents (DES). Among the variety of causes of stent thrombosis after DES implantation, coronary endothelial dysfunction manifested or exaggerated by DES implantation should not be overlooked. This review article summarizes previous reports on coronary endothelial dysfunction after DES implantation and/or coronary spasm … …Current Research in Medicine, Vol. 3, Issue 2 · 30 Apr 2012 · 7,936 accessesView PDFCite
Research ArticleOpen accessIn the keywordsIn Silico Cholinesterase and Monoamine Oxidase Inhibitory Activities of Perillaldehyde and D-Limonene, Main Compounds of Essential Oil of Algerian Ammodaucus leucotrichusNesrine Sadaoui-Smadhi, Souad Khemili-Talbi, Wadood Abdul et al.In a continuation of our previous work for the exploration of novel enzyme inhibitors, molecular modeling was used to inspect the binding mode of perillaldehyde and D-limonene, the major compounds of essential oil of Algerian Ammodaucus leucotrichus into the active site pocket of cholinesterase (AChE and BuChE) and Monoamine Oxidase (MAO). The molecular docking was carried out using Molecular Operating … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 28 Feb 2020 · 7,313 accessesView PDFCite