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Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Phenotypically Suppressed Cancer Cell As a Therapeutic TargetKimberly D. Kyker, Jessica E. Thorpe, Satyendra S. Shenoy et al.Bladder cancer recurs in up to 70% of patients judged to be tumor-free after treatment. Like other cancers, delayed appearance of metastases is common. These findings suggest the malignant phenotype can be suppressed, to emerge later. Following up on previous research in our laboratory showing that normal extracellular matrix can suppress the malignant phenotype of bladder cancers, we here demonstrate … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,471 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessment of Measles Surveillance in Iran during 2004-2007Mohammad-Arash Ramezani, Neda Zamani, Esmaeel Akhtar et al.Elimination of measles using vaccination is one of the most important task worldwide. Iran is in the elimination phase of measles and health professionals base surveillance system on reporting of suspected cases. The aim of this study was to evaluate measles surveillance in center of Iran. The epidemiological data was collected from immediate telephone reports and follow up results in … …American Journal of Infectious Diseases, Vol. 2, Issue 4 · 31 Dec 2006 · 6,461 accessesView PDFCite
Research ArticleOpen accessIn the abstractPathophysiology of Adipocyte Defects and Dyslipidemia in HIV Lipodystrophy: New Evidence from Metabolic and Molecular StudiesAshok Balasubramanyam, Rajagopal V. Sekhar, Farook Jahoor et al.Despite a burgeoning mass of descriptive information regarding the epidemiology, clinical features, body composition changes, hormonal alterations and dyslipidemic patterns in patients with HIV lipodystrophy syndrome (HLS), the specific biochemical pathways that are dysregulated in the condition and the molecular mechanisms that lead to their dysfunction, remain relatively unexplored. In this paper, we review studies that detail the metabolic basis … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,608 accessesView PDFCite
Research ArticleOpen accessIn the abstractLeptin and Adiponectin in the HIV Associated Metabolic Syndrome: Physiologic and Therapeutic ImplicationsSotirios Tsiodras, Christos MantzorosLeptin and adiponectin represent two newly discovered adipose tissue derived hormones with important roles in energy homeostasis and insulin resistance. Their interrelations with the manifestations of the HIV associated metabolic syndrome and specific somatomorphic changes i.e. fat redistribution is reviewed. A synopsis of published studies is presented and the potential role of leptin and adiponectin is discussed. We have described … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 10,099 accessesView PDFCite
Research ArticleOpen accessIn the abstractAge Difference in Immunophenotype of Acute LeukemiaKazunori Nakase, Mary Sartor, Kenneth BradstockWe examined the immunophenotype of 880 cases with acute leukemia and analyzed their age difference in relation to the morphological subtype and the karyotype. We divided the patients into 3 age groups: child (0-15 years), adult (16-59 years) and elderly (60 years and older) group. The diagnoses based on the French-American-British (FAB) criteria and the immunophenotype as follows: 453 patients … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,941 accessesView PDFCite
Research ArticleOpen accessIn the abstractRisk of Second Non Breast Malignancies (SNBM) in Relation to Brca1 And Brca2 Mutation Status Following Breast-Conserving Surgery and RadiotherapyYoulia M. Kirova, Alain Fourquet, Alexia Savignoni, Brigitte Sigal-ZafraniWomen from hereditary breast cancer families with BRCA1/2 germline mutation are at increased risk for contralateral breast cancer (BC) and for ovarian cancer (OC). It is less clear whether mutation status influences the rate of SNBM other than OC. In addition, little is known on the risk of OC in individuals from hereditary BC families without identified BRCA mutation. Our … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 7,228 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,857 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuropsychological Complications of HIV Disease and Substances of AbuseLisa R. Norman, Anil KumarIn the last decade, it has become increasingly apparent that neuropsychological deficits and impairments are associated with HIV infection. Given that antiretroviral therapies have extended the life expectancy of HIV-infected persons, it becomes critical to focus on the physical and mental health of these patients. Understanding the neuropsychology of HIV disease can provide insight into improving mental health, functional capacity … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractTopical Cyclosporine A in Corneal Graft RejectionMahmood Nejabat, Jafar Khoshghadam, Masoomeh Eghtedari, Hamid HosseiniCorneal graft rejection is now the most common cause of graft failure after penetrating keratoplasty. This study was designed to determine whether, addition of 2% topical cyclosporine (CSA) to local and systemic steroids in treatment of endothelial corneal allograft rejection, would improve the outcome. A prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,317 accessesView PDFCite