86 results for “drug development”

Set a search alert

Research ArticleOpen accessAll words, across the recordKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,101 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDevelopment of Improved Preventive and Treatment Strategies for Controlling of Toxoplasmosis in Saudi ArabiaAlaa B. Ismael, Ayman A. Swelum, Mohammed A. NassanToxoplasmosis causes severe public health problems and has great veterinary and economic importance worldwide. The present study aims mainly to develop an improved preventive and treatment program for controlling toxoplasmosis in sheep and goats. This study was performed on sheep and goats farm containing 357 animals (300 sheep and 57 goats). This farm had a large numbers of barren ewes, … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 14 Jun 2016 · 7,731 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDevelopment of a Short-Term Canine Full-Thickness Skin Organ Culture Method under Serum-Free ConditionsFrancesca Abramo, Andrea Pirone, Carla Lenzi et al.Full-thickness canine skin organ culture models could provide an entirely new opportunity for studying wound healing, keratinization disorders and allergic skin diseases, all of which have high prevalence and severe impact on canine quality of life. Here we present a canine organ culture method for the short-term maintenance of full-thickness, adult, canine skin in serum-free medium and investigate the possibility … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 2 · 13 Jun 2016 · 7,380 accessesView PDF Cite

Review ArticleOpen accessAll words, across the recordHerbal Compounds-An Alternative for Multi-Drug Resistant Vibrio CholeraeSabah Perveen, Hotam Singh ChaudharyVibrio cholerae is a causative agent of cholerae, many people dies every year, especially in developing countries around the world. The outbreaks of cholera are responsible for approximately 120,000 deaths annually. Cholera is a self limiting illness; however antibiotics are used as a part of treatment regimen. But at present, the treatment against cholera has become very critical issue worldwide, … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 12 Oct 2015 · 7,260 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDevelopment and Optimization of Plant Extract Loaded Nanoemulsion Mixtures for the Treatment of Inflammatory DisorderMukesh Gohel, Tejal Soni, Lal Hingorani et al.In current study, a nanoemulsion as drug delivery system (NE) of spray dried Boswellia Serrata Extract (BSE) was developed and characterized to compare it in vitro/Ex vivo diffusion with reference formulation. Pseudo-ternary phase diagrams were constructed by phase diagram by aqueous titration method, of which the evaluation method was improved for solubility, Droplet size and transmittance. The formulation of BSE-loaded … …Current Research in Drug Discovery, Vol. 1, Issue 2 · 26 Jan 2015 · 14,064 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordRetinoids and Opioids: Factors in the Development of HIV-Related Neurological DiseaseWalter Royal, III, Joseph L. BryantNeurological disease occurs frequently in HIV-infected individuals and may occur at even higher rates among infected drug users. Among the potential mechanisms that promote such impairment, retinoid deficiency may have selective effects that could both lead to alterations in immune function and enhanced replication of HIV. Studies are currently underway to examine the possible selective effects of retinoid receptor activation … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 6,764 accessesView PDF Cite