85 articles for “Clinical Experiment”

Research ArticleOpen accessIn the abstractPathophysiology of Adipocyte Defects and Dyslipidemia in HIV Lipodystrophy: New Evidence from Metabolic and Molecular StudiesAshok Balasubramanyam, Rajagopal V. Sekhar, Farook Jahoor et al.Despite a burgeoning mass of descriptive information regarding the epidemiology, clinical features, body composition changes, hormonal alterations and dyslipidemic patterns in patients with HIV lipodystrophy syndrome (HLS), the specific biochemical pathways that are dysregulated in the condition and the molecular mechanisms that lead to their dysfunction, remain relatively unexplored. In this paper, we review studies that detail the metabolic basis … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,608 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPhysics Models of Pronuclear Movements in EggsKang Cheng, Changhua ZouBased on published experimental data, Newton's laws, and Coulomb's law, we investigate natural and normal pronuclear movements in wild types of eggs and develop physics models to fit the experimental data quantitatively. The difference between our modeling calculated results and the experimental data is less than 20%. Our models explain why and how pronuclei move in even or in variant … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,743 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordCLINICAL EXPERIENCE OF CANCER IMMUNOTHERAPY INTEGRATED WITH OLEIC ACID COMPLEXED WITH DE-GLYCOSYLATED VITAMIN D BINDING PROTEINEmma Ward, Rodney Smith, Jacopo J.V. Branca et al.Proteins highly represented in milk such as α-lactalbumin and lactoferrin bind Oleic Acid (OA) to form complexes with selective anti-tumor activity. A protein present in milk, colostrum and blood, vitamin D binding protein is the precursor of a potent Macrophage Activating Factor (GcMAF) and in analogy with other OA-protein complexes, we proposed that OA-GcMAF could demonstrate a greater immunotherapeutic activity … …American Journal of Immunology, Vol. 10, Issue 1 · 8 Mar 2014 · 13,186 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordUsing Feature Selection as Accuracy Benchmarking in Clinical Data MiningJafreen Hossain, Nor FazlidaMohdSani, Aida Mustapha, Lilly SurianiAffendeyAutomated prediction of new patients’ disease diagnosis based on data mining analysis on historical data is proven to be an extremely useful tool in the medical innovation. There are several studies focusing on this particular aspect. The objective of this study is two-fold. First, we look into three different classifiers, which are the Naïve Bayes, Multilayer Perceptron (MLP) and Decision … …Journal of Computer Science, Vol. 9, Issue 7 · 20 Jun 2013 · 7,460 accessesView PDF Cite