100 articles for “Animal Model”

Research ArticleOpen accessIn the abstractNeuroprotective Effect of Quercetin Encapsulated Liposomes: A Novel Therapeutic Strategy against Alzheimer’s DiseaseW. Phachonpai, J. Wattanathorn, S. Muchimapura et al.Problem statement: The prevalence of Alzheimer’s disease is increasing but the efficacy of treatment is still very limited due to various factors including the blood brain barrier. Recent findings demonstrated the crucial role of oxidative stress on the pathophysiology of disease. In addition the burden of blood brain barrier can be overcome by nasal administration and vesicle-carrier mediated delivery system. … …American Journal of Applied Sciences, Vol. 7, Issue 4 · 30 Apr 2010 · 9,449 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEcological Capability Assessment for Multiple-Use in Forest Areas Using GIS- Based Multiple Criteria Decision Making ApproachSasan Babaie-Kafaky, Asadollah Mataji, Naser Ahmadi SaniProblem statement: A valuable Source of plant and animal various species in the west of Iran is Zagros forests that, misuses by foresters and local societies has caused severe degradation. In this study, forest areas ecological assessment was carried out with a (GIS)-based MCDM approach for multiple-use planning in order to reduce degradation and improving sustainability. Approach: All of possible … …American Journal of Environmental Sciences, Vol. 5, Issue 6 · 31 Dec 2009 · 7,887 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFactors Causing Deaths Due to Injury among Children in BangladeshMd Hasinur Rahaman Khan, Tahera Ahmed, Faisal AbabnehBangladesh experiences high infant and child mortality for many years, for which child injury appears to be one of the most important modes of mortality. We modelled “death due to injury” using a logistic regression to study the differentials of death due to accidental injuries fall, drowning, road accident, burn, poisoning, animal bite, cut according to different socio-economic characteristics using … …Journal of Mathematics and Statistics, Vol. 11, Issue 2 · 22 Sep 2015 · 8,309 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRadiation-Induced Cognitive Dysfunction After Different Schemes of Fractionated Whole Brain IrradiationZorkina Yana Alexandrovna, Zubkov Eugene Andreevich, Yusubalieva Gaukhar Maratovna et al.Radiation-induced cognitive dysfunction is a serious complication of radiation therapy. In humans, numerous cases of radiation damage have been recorded after irradiation for therapeutic purposes. The degree of cognitive dysfunctions and its dependence on biological effective doses should be tested in animal preclinical models to minimize radiation side effects. Fractionated whole brain irradiation was performed according to the following schemes: … …Neuroscience International, Vol. 5, Issue 2 · 14 Jan 2015 · 7,256 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIn Vivo Neutralization of Naja nigricollis Venom by Uvaria chamaeOmale James, Ebiloma Unekwuojo Godwin, Idoko Grace OtiniUvaria chamae is a well known medicinal plant in Nigerian traditional medicine for the management of many diseases, but investigations concerning its pharmacological characteristics are rare. In this study, we evaluate its venom neutralizing properties against Naja nigricollis venom in rats. Freshly collected Uvaria chamae leaves were air dried, powdered and extracted in methanol. To study the antivenom properties, albino … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 8,421 accessesView PDF Cite

Research ArticleOpen accessIn the abstractClinical and Reproductive Pathological Changes Associated with Brucella melitensis and its Lipopolysaccharides in Female Mice Via Oral InoculationFaez Firdaus Jesse Abdullah, Lawan Adamu, Nur Hazirah et al.Brucella melitensis (B. melitensis) are Gram-negative, aerobic, facultative intracellular bacteria that cause brucellosis that usually leads to abortion in sheep and goats. Three groups of equal number of 24 healthy female mice were used as animal models. They were orally inoculated with 0.4 mL of phosphate Buffered Saline (PBS-Control group), 0.4 mL of 109 cfu of B. melitensis and 0.4 … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 3 · 30 Aug 2013 · 8,572 accessesView PDF Cite

Research ArticleOpen accessIn the abstractLagrangian Micromixing Models for Concentration Fluctuations: An OverviewPaolo Monti, Giovanni Leuzzi, Andrea AmicarelliThis study presents a brief overview of the main features, theoretical formulations and validation tests of some Lagrangian micromixing models, currently used for estimations of the ensemble mean and the turbulent fluctuations of concentration. Their application fields regards several pollutant dispersion phenomena such as: accidents (power or production plants, terroristic attacks, hydrocarbons storage and transport, extraordinary emissions), odours (power plants … …American Journal of Environmental Sciences, Vol. 8, Issue 6 · 28 Dec 2012 · 6,779 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCancerous Immunoglobulins and CA215: Implications in Cancer ImmunologyGregory LeeImmunoglobulins are typically expressed by B cells in our normal immune system. However, certain normal human tissues, such as hyperplastic epithelial cells, cells of the immunologically privileged sites and the majority of cancer cells, have also been found to be sites of immunoglobulin production. Current research is lacking in regards to the differential immunoglobulin expression, the underling mechanisms of action … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Sep 2012 · 8,942 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDietary Fats and Heart Disease: From Prenatal to Postnatal EnvironmentSukhinder K. CheemaProblem statement: Heart disease is the leading cause of death worldwide and is dramatically increasing in developing countries. Preventive approaches, such as dietary and lifestyle changes can have major health implications to prevent the onset of heart disease. Besides healthy nutrition in the adult life, maternal nutrition during pregnancy and lactation can also have a significant impact on the outcome … …Current Research in Medicine, Vol. 3, Issue 2 · 10 Aug 2012 · 7,433 accessesView PDF Cite