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98 articles for “protein structure”
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Research ArticleOpen accessIn the abstractIn-silico Rational Protein Engineering and Design Approach to Improve Thermostability of a Haloalkane Dehalogenase EnzymeRaghunath Satpathy, V. Badireenath Konkimalla, Jagnyeswar RathaThermostability of enzymes is a major prerequisite for use in industrial enzymology. There are as such no simple general principles for achieving thermostability in case of enzymes as many factors are required to fulfil for different enzymes. The present study describes computational methods to design thermostable haloalkane dehalogenase enzyme using the crystal structure available Protein Data Bank (PDB ID: 1EDE). … …Current Research in Bioinformatics, Vol. 4, Issue 2 · 13 Oct 2015 · 8,285 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynergistic Effects of Wheat Bran and Inoculants on Fermentation and Nutritional Quality of Soybean Straw SilageLie Yang, Rundong Qin, Jiahuan Liu et al.The efficient valorisation of lignocellulosic biomass from soybean straw into high-quality silage remains a pressing challenge for sustainable livestock production. This study employed a 3×3 factorial design to systematically investigate the interactive effects between wheat bran additions (0%, 10%, 20% of fresh weight) and microbial inoculant regimes (control, Effective Microorganisms, EM+Trichoderma longibrachiatum) on soybean straw silage quality. Two-way ANOVA revealed … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 1 Jul 2026 · 1,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparison of Ferrous Ion Chelating Properties of Collagen Peptides from Dried and Fresh Cod SkinMengqian Chen, Cen Chen, Junchao Wu et al.Fish skin is a potential source of collagen and collagen is a protein source of bioactive peptides including iron chelating peptides. The aim of this study is to compare physicochemical properties of collagen extracted from fresh and dried cod skin and the ferrous ion chelating properties of collagen hydrolysates. Then the fresh and dried cod skin extracted collagen was hydrolyzed … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 3 · 2 Jul 2021 · 7,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Characterization and Differentiation of Proteases Isolated from Different Aspergillus Fungal SpeciesSamia Abd Allah Abdal-Aziz, Safaa M. AliA comparative molecular study of Aperigiullus protease using sequence of protease gene representative 25 different Aspergillus species (Aspergillus fumigatus, Aspergillus oryzae, Aspergillus flavus, Aspergillus novofumigatus, Aspergillus viridinutans, Aspergillus pseudotamarii, Aspergillus clavatus, Aspergillus sojae, Aspergillus fischeri, Aspergillus caelatus, Aspergillus novofumigatus, Aspergillus campestris, Aspergillus costaricaensis, Aspergillus candidus, Aspergillus neoniger, Aspergillus mulundensis, Aspergillus ibericus, Aspergillus niger, Aspergillus piperis, Aspergillus eucalypticola, Aspergillus vadensis, Aspergillus … …OnLine Journal of Biological Sciences, Vol. 21, Issue 1 · 11 Feb 2021 · 6,653 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Modeling of α1A-Adrenoceptor: Interaction of its Normal and Mutated Active Sites with Noradrenaline as well as its Agonist and AntagonistRamchandran Vijayan, Naidu Subbarao, Birendra Nath MallickNoradrenaline, like most other neurotransmitters, acts through various adrenoceptor subtypes. The structure and active site of adrenoceptors for the binding of noradrenaline were unknown, however, such information are crucial for understanding the molecular mechanism of action of neurotransmitters, including noradrenaline, in health and disease as well as for drug designing. In this in silico study, we modeled the α1A-adrenoceptor; a … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,144 accessesView PDFCite
Research ArticleOpen accessIn the abstractComputer Aid Screening for Potential Antimalarial Choroquinone Compounds as Covid 19 Utilizing Computational Calculations and Molecular Docking StudyAsmaa Aboelnaga, Asmaa M. Fahim, Taghreed H. EL-SayedClick reaction of 4,7-dichloroquinoline (1) with thiosemicarbazide (2) to afford the corresponding 2-(7-chloroquinolin-4-yl)thiosemicarbazide (3) utilized ultrasonic irradiation which can cyclized easily with ethylacetoacetate to give the 3-(7-chloroquinolin-4-ylamino)-tetrahydro-6-methyl-2-thioxopyrimidin-4(1H)-one (4) via nucleophilic substitution reaction. The synthesized compounds was examined in vitro antimalarial activity with IC50 = 11.92, 25.37 μg/mL against chloroquinone drug. Furthermore, the theoretical investigation of most active compounds CQT and … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 30 Nov 2020 · 6,570 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with CancerEddaikra Atika, Haddouche Hayet, Touil-Boukoffa ChafiaThe human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17q21,32 and consists of 11 exons. The characterization and understanding of genetic variation is a real challenge in human genetics, both for healthy individuals and diseased ones. The in silico study of the B4GALNT2 … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractProducts of Solid-Phase Probiotic Bacilli Fermentation Increase Food Conversion Efficiency and Stimulate Chicken GrowthMazanko Maria S., Aleksandr I. Klimenko, Ivan F. Gorlov et al.Poultry farming is one of the major directions in agriculture. Agricultural poultry has high growth speed, productivity and is resistant to the industrial environment. Our group carried out a study of probiotic preparations of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 strains. These preparations were made by solid-phase fermentation and tested for dynamical germination of rearing flock (Highsex brown). The … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 4 · 4 Dec 2018 · 9,379 accessesView PDFCite
Research ArticleOpen accessIn the abstractConservation of Binding of Llama and Other Animals’ Hemoglobins to Haptoglobins Across SpeciesMoges Woldemeskel, Oluseyi A. VanderpuyeThe plasma protein haptoglobin binds hemoglobin released from lysed erythrocytes. It causes removal of the free hemoglobin, thus preventing pathological oxidation of cells. Hemoglobin higher level structures are well conserved across animal species but primary structures can be as little as 50% homologous. Because of these differences, the question arose as to what extent hemoglobins can bind to haptoglobins from … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 26 Jan 2018 · 9,203 accessesView PDFCite
Research ArticleOpen accessIn the abstractUltrastructural and Immunological Characterization of Hepatitis C Core Protein-DNA Plasmid ComplexesNelson Acosta-Rivero, Yaraima Aguilera, Viviana Falcon et al.Recently, it has been shown that a truncated HCV core (HCcAg) variant, covering the first 120 aa (HCcAg.120), interacts with plasmid DNA vaccine (pIDKE2), encoding the HCV structural proteins (HCcAg, E1 and E2). In the present work, HCcAg.120-pIDKE2 complexes, forming heterogeneous packaged structures, were visualized using a negative stain/rotary shadow technique. Interestingly, 72 hours after intramuscular injection of HCcAg.120-pIDKE2 complexes … …American Journal of Immunology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,746 accessesView PDFCite