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87 articles for “molecular studies”
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Research ArticleOpen accessIn the abstractTolemerase Reverse Transcriptase Gene Expression as a Tumor Marker for Hepatocellular CarcinomaM. Magdi Atta, Naglaa Al-Toukhy, Omnia Al-Said et al.Problem statement: Hepatocellular carcinoma will emerge as a major form of malignancy in the coming decades. The continuing high incidence of hepatocellular carcinoma, suggests that this disease will continue to represent a global health problem far into the future. Different genes encode for the various components of the human telomerase complex. These components include the human Telomerase RNA Component (hTERC) … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 3 Aug 2011 · 7,905 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Extractants on the Yields and Selected Chemical Characteristics of Humic Acids Isolated from Tropical Saprists PeatLee Jia Huey, Osumanu Haruna Ahmed, Nik Muhamad Ab. MajidProblem statement: Humic acids are beneficial to soil aggregation, binding of heavy metal, plant growth and many more. However, the isolation of Humic Acids (HA) from its origin is not only time-consuming, but the isolation is also affected by factors such as temperature and the types of extractants and their concentrations. Different concentrations of extractant are said to alter the … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 7,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Clonal Clusters of Klebsiella pneumoniae Isolates from Chennai by Extended Spectrum Beta Lactamase Genotyping and Antibiotic Resistance Phenotyping AnalysisC. Kamatchi, H. Magesh, Uma Sekhar, Rama VaidyanathanProblem statement: An increased resistance to antibiotics has been reported in Klebsiella pneumoniae, an opportunistic gram negative pathogen belonging to Entrobacteraceae due to the evolution and spread of plasmid encoded extended spectrum beta lactamases and other genes conferring cross-resistance to other antibiotics. This is of concern due to the increasing cost of antibiotic treatment and the spread of multidrug resistance … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,953 accessesView PDFCite
Research ArticleOpen accessIn the abstractResistance to Third-Generation Cephalosporins and Other Antibiotics by Enterobacteriaceae in Western NigeriaA. O. Okesola, O. MakanjuolaProblem statement: The emergence and spread of resistance to third-generation cephalosporins are threatening to create species resistant to all currently available agents. The most common cause of bacterial resistance to beta-lactam antibiotics is the production of beta-lactamases and many of the 2nd and 3rd-generation penicillins and cephalosporins were specifically designed to resist the hydrolytic action of major β-lactamases. However new … …American Journal of Infectious Diseases, Vol. 5, Issue 1 · 31 Mar 2009 · 8,007 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Certain Tetracyclines and Oxytetracyclines through Charge Transfer ComplexationKhairi M.S. FahelelbomProblem statement: Several studies were carried out to develop and validate a simple, rapid and accurate spectrophotometric method for the analysis of tetracycline (TC) and oxytetracycline (OTC) in the pure form and in pharmaceutical dosage forms, despite the varieties of these analytical techniques, the literature revealed that no spectrophotometric method for determination of tetracycline and oxytetracycline using charge transfer complexation … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 3 · 30 Sep 2008 · 8,528 accessesView PDFCite
Research ArticleOpen accessIn the abstractElucidating the Mechanism(s) of Hormesis at the Cellular Level: The Universal Cell ResponsePaul S. AgutterMany environmental stressors elicit biphasic effects from single cells. Such cellular hormesis may be interpreted in terms of (a) the superimposition of simple biochemical processes or (b) the non-specific behaviour of the cell. The latter approach is emphasized in this article and identified with the universal cell response (UCR); however, the importance of identifying molecular-level concomitants of the UCR is … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 13,112 accessesView PDFCite
Research ArticleOpen accessIn the abstractAT1-IR-beta Association: A New Mechanism for the Inhibition of Insulin Receptor Function in Breast CancerLakshmi Pulakat, Ravindra Kolhe, Nara GaviniEpidemiological evidence show that increased mortality in breast cancer is linked to hypertension and insulin resistance. Because Angiotensin II (Ang II), a hormone implicated in hypertension and insulin resistance, is a normal mitogen for breast tissue and elevated expression of the Ang II receptor AT1 is seen in breast cancer, we analyzed the effects of Ang II exposure on the … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,016 accessesView PDFCite
Research ArticleOpen accessIn the abstractAccumulation of Cholesterol Esters in ex vivo Lymphocytes from Scrapie-susceptible Sheep and in Scrapie-infected Mouse Neuroblastoma Cell LinesAlessandra Pani, Claudia Norfo, Claudia Abete et al.Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie in sheep, revealed abnormal accumulation of cholesterol esters in brains and in ex vivo skin fibroblasts from genetically scrapie-susceptible, as compared to sheep with resistant genotype. We now report that PBMCs isolated from scrapie-susceptible sheep, as well as mouse neuroblastoma cell lines persistently infected with two different … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 6,955 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh Concentrations of Glucose can Activate or Inhibit Human Erythrocyte Aminolevulinate Dehydratase in vitro Depending Exposure TimeJ. C. Soares, D. Gabriel, V. Folmer et al.Hyperglycemia can cause oxidative stress and inactivate susceptible enzymes. In the present investigation we examined whether short-term incubations (24 or 48 h) with high concentrations of glucose (10-200 mmol L-1) inhibit ALA-D from human erythrocytes. Incubations of erythrocytes for 24 h with glucose (10 up to 40 mmol L-1) resulted in an increase of δ-ALA-D activity (P<0,001). Incubations of erythrocytes … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,686 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiochemical Effects of Recombinant Porcine Somatotropin on Pig Fetal Growth and Metabolism: A ReviewD. Villanueva-García, S. A. Olmos-Hernández, D. Mota-Rojas et al.Prenatal development is mainly dependent on a close interrelation between nutritional supply use and regulation by hormones and growth factors. Mechanisms during early embryonic development are sensitive to manipulation through selected management strategies of the sow and modifications of this strategy may serve as a model for the examination of molecular and cellular events controlling early embryonic growth. The administration … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,620 accessesView PDFCite