78 articles for “dysfunction”

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Research ArticleOpen accessIn the abstractOpiates Upregulate Adhesion Molecule Expression in Brain MicroVascular Endothelial Cells (BMVEC): Implications for Altered Blood Brain Barrier (BBB) PermeabilityMadhavan P.N. Nair, Supriya D. Mahajan, Jessica L. ReynoldsThe blood-brain barrier (BBB) is an intricate cellular system composed of vascular endothelial cells and perivascular astrocytes that restrict the passage of immunocompetent cells into the central nervous system (CNS). Expression of the adhesion molecules, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) on brain microvascular endothelial cells (BMVEC) and their interaction with human immunodeficiency virus (HIV-1) … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,610 accessesView PDF Cite

Review ArticleOpen accessIn the abstractTherapeutic Potential of Medicinal Plants Grown in the Bundelkhand Region of India for Addressing Severe Non-communicable DiseasesNeelam Kashyap, Abha Sachan, Prakash Chandra et al.Herbal Medicines (HMs) have experienced exponential development in the past few years. Consequently, their natural origins and minimal side effects, the popularity of these medications is gradually growing across the globe. Ancient text Rigveda has well documented the remedial application of medicinal herbs for the management of a spectrum of disorders. Phytometabolites derived from plants are rich in bioactive agents, … …American Journal of Agricultural and Biological Sciences, Vol. 20, Issue 1 · 17 Jun 2025 · 6,951 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Note on the Renovation of Social Enterprise in Korea: Current Status and Future ProspectsSeok Yoon, Yoon-Doo KimSocial enterprise activities in Korea began after 1998. Korea was facing the IMF Financial Crisis which yielded growing unemployment and slow economic growth. The government, therefore, carried out the Social Job Creation Project for the unemployed on a trial basis as ways to provide jobs to the vulnerable. Since 2004, it has become a government-wide project. Moreover in 2007, the … …American Journal of Applied Sciences, Vol. 13, Issue 6 · 30 May 2016 · 7,528 accessesView PDF Cite

EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,149 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Innate Immunity in Bovine Mastitis: The Role of Pattern-Recognition ReceptorsFernando Nogueira de Souza, Eduardo Milton Ramos Sanchez, Marcos Bryan Heinemann et al.Mastitis is the most costly disease for dairy farmers and industry, which are mainly caused by the entry of bacteria to the teat canal. Shortly after the entry of the invading bacteria, the innate immunity recognizes the invading pathogen through pattern recognition receptors and initiates the inflammatory response necessary to eliminate the invading bacteria. This initial inflammatory response releases cytokines … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 10,352 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Implications of Teacher Effectiveness Requirements for Initial Teacher Education ReformS. G. PretoriusProblem statement: School effectiveness research shows that teacher effectiveness is the single most important school-based factor in student success. The effects of poor teaching linger and can be measured for at least three years after students have left the classroom. It is too late to wait until secondary school level for backlogs to be eradicated. Education systems, such as the … …Journal of Social Sciences, Vol. 8, Issue 3 · 26 Mar 2012 · 9,481 accessesView PDF Cite

Research ArticleOpen accessIn the abstractA Disruption-Tolerant Model for Building a Mobile Application Using Web ServiceMaryati Mohd. Yusof, Mansor Omar, Zarina ShukurProblem statement: The emerging technology in broadband telecommunication and mobile devices has increased the use of mobile applications. However, the use of mobile application is affected with low bandwidth or disrupted broadband telecommunication due to building blockage or out of coverage area. Approach: We proposed a Disruption-Tolerant Mobile Application Model (DTMA) that enables remote data access and overcomes constraint due … …Journal of Computer Science, Vol. 6, Issue 12 · 1 Dec 2010 · 7,219 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Interplay between p53 and p21 Tumor Suppressor Proteins in the Transformation of Colorectal Adenoma to CarcinomaA.S. Abdulamir, R.R. Hafidh, L.K. Mahdi et al.This study was carried out for evaluating the interplay of p53, p21 and Ki-67 proteins along the colorectal adenoma-carcinoma oncogenic transformation sequel. Therefore, Fifty colorectal cancer and 14 adenoma patients were involved. The histopathological expression of p53, p21 and Ki-67 proteins was evaluated by immunohistochemistry assay. The results revealed that remarkable overexpression of p53 protein was seen in the tumorous … …American Journal of Immunology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,740 accessesView PDF Cite