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212 results for “Liver”
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Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,456 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,079 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,341 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Dietary Supplementation of a Mix of Chestnut and Quebracho Tannins on Intestinal Morphology, Bacterial Load, Eimeria spp oocyst Excretion and Immune Response after Vaccination in RabbitsFrancesca Parisi, Simone Mancini, Maurizio Mazzei et al.Among plant products, tannins exhibited a strong antioxidant activity and their employment was studied as food or feed addictive with positive effects. Nevertheless, their health-enhancing properties remain to be completely clarified, particularly in rabbits. The aim of the present study was to investigate the influence of a mix of chestnut and quebracho tannins as supplementation in rabbit diet on intestinal … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 3 · 3 Aug 2018 · 8,630 accessesView PDFCite
Review ArticleOpen accessIn the abstractFrom Health to Disease: Functional Insights of Scavenger Receptor Class B Type I in Lipid Metabolism and Disease PathogenesisSujina Simon Sailet, Poornima Ajay Manjrekar, Santosh Rai et al.Scavenger receptor class B type I (SR-B1) has caught considerable interest among the scientific community due to its pivotal role in several biological and pathological processes. It is a multifunctional integral membrane protein and multiligand receptor encoded by the SCARB1 gene. SR-B1 has a wide distribution, primarily in the liver as well as steroidogenic organs including the gonads and adrenal … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 11 Jul 2025 · 3,672 accessesView PDFCite
Case ReportOpen accessIn the abstractSurvival Following Severe Paraquat Poisoning a Case Study from the Andaman and Nicobar IslandsShiv Shankar Singh, Colin Sanchez, Prasan Kumar PandaParaquat poisoning continues to pose a significant public health challenge in the Andaman and Nicobar Islands, largely due to its alarmingly high mortality rate. In this report, we present the case of a 39-year-old male farmer who ingested 30 mL of paraquat with the intent of suicide. Initially, the patient underwent prompt gastric lavage and exhibited relative stability. Upon admission, … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 22 Jan 2025 · 10,617 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Phenolic Ester of O-Desmethylvenlafaxine (ODV) Improves Uptake of ODV into the BrainYang Zhang, Zhichao Yang, Sen Zhao, Hongli ZhouIn this study, the in vitro stabilities of a promising O-Desmethylvenlafaxine (ODV) phenolic ester prodrug O-19 in aqueous solution, rat whole blood and rat liver microsomes were investigated. In addition, the in vivo drug metabolites were determined using LC-TOFMS-IDA-MS/MS. O-19 exhibits high stabilities at any pH encountered in the gastrointestinal tract, its half live (t1/2) spans the range 5.0±0.18 d … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 4 · 11 Dec 2016 · 7,162 accessesView PDFCite
Case ReportOpen accessIn the abstractEpistein-Barr Virus Infection with Concurrent Pancreatitis and Hepatitis: A Rare Disease EntityJered Cook, Megha Kothari, Andrew NguyenConcurrent acute hepatitis and acute pancreatitis is a rare disease entity. Most commonly it can be attributed to infectious etiologies such as hepatitis A, Hepatitis B and Hepatitis E. Although not as common, Epstein Barr Virus (EBV) should be considered in the differential diagnosis in patients with combined hepatitis and pancreatitis. We report a case of a 25 year-old male … …American Journal of Infectious Diseases, Vol. 11, Issue 3 · 18 Sep 2015 · 7,839 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Relation between Helicobacter Pylori Infection and Hepatocellular Carcinoma in Egyptian PatientsWaleed Mohamed SeragThis work to show the relation between Helicobacter Pylori infection and Hepatocellular Carcinoma in Egyptian patients. This study was completed at National liver institute in Egypt. Patients in this study were recognized cases of chronic Hepatitis C virus liver disease with and without hepatocellular carcinoma. Serum samples of patients of hepatocellular carcinoma with hepatitis C Virus (HCV) of 40 male … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 25 Jun 2015 · 7,021 accessesView PDFCite
Research ArticleOpen accessIn the abstractNitric Oxide Donors with Therapeutic Strategic in Experimental Schistossomiasis MansoniWander Rogério Pavanelli, Jean Jerley Nogueira da Silva, Carolina Panis et al.Schistosomiasis, an immune disease, remains a major public health problem in endemic area. To determine the influence of Nitric Oxide (NO) on this disease, we tested two compounds (Trans-[Ru(bpy)2(NO)SO3](PF6)-PF6 and Na2[Fe(CN)5(NO)]-SNP, which releases NO when activated by biological reducing agents, in BALB/c mice infected subcutaneously by Schistosoma BH strains. The parasitic activity of NO-donors was evaluated in this model by … …American Journal of Immunology, Vol. 10, Issue 4 · 24 Feb 2015 · 7,852 accessesView PDFCite