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95 articles for “Insulin”
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Research ArticleOpen accessIn the abstractMolecular Mechanisms for Altered Glucose Homeostasis in HIV InfectionPaula W. HruzA complete understanding of the molecular mechanisms leading to HIV-associated insulin resistance remains elusive. Complex interrelationships between genetic predisposition, disease-related body changes and multidrug therapy all contribute to alterations in glucose homeostasis. These abnormalities can be differentiated between acute and reversible changes directly induced by HAART medications and more chronic and less reversible changes due to the development of lipodystrophy … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,882 accessesView PDFCite
Research ArticleOpen accessIn the abstractMetabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase InhibitorsMadhu N. Rao, Grace A. Lee, Carl GrunfeldThe use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,941 accessesView PDFCite
Research ArticleOpen accessIn the abstractPDX-1 and MafA: Key Transcription Factors in PancreasHideaki Kaneto, Takeshi Miyatsuka, Yoshihisa Nakatani, Taka-aki MatsuokaPancreatic and duodenal homeobox factor-1 (PDX-1) plays a crucial role in pancreas development, β-cell differentiation and in maintaining normal β-cell function by regulating several β-cell-related genes including insulin. PDX-1 has potency to induce insulin-producing cells in non β-cells in various tissues such as pancreas and liver and PDX-1-VP16 fusion protein more efficiently induces insulin-producing cells, especially in the presence of … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,391 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Euphorbia helioscopia Extract Administration on Diabetes Induced by Alloxan in MiceDoha Mohammad Beltagy, Amira Mohammed Beltagy, Mohammad Ramadan et al.Diabetes describes metabolic disorder with hyperglycemia and neurotic changes. This work aimed to evaluate the protective effect of total ethanolic extract of Euphorbia helioscopia grown in Egypt against pancreas and brain injuries in diabetic mice induced by alloxan. This work was carried out on 60 mice divided into four groups. Control Group (G1) included healthy normal mice that did not … …OnLine Journal of Biological Sciences, Vol. 20, Issue 3 · 19 Oct 2020 · 6,412 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico Assessment of the Arg85Trp Glucokinase Mutation EffectsFaiza Bouldjennet, Souhila Bouaziz-Terrachet, Malha Azzouz, Rachida RaacheMaturity Onset Diabetes of the Young (MODY) is a heterogeneous group of autosomal dominantly inherited, young-onset β-cell disorders that account for approximately 2% of non-insulin-dependent diabetics in Europe. MODY2 or GCK-MODY is caused by inactivating heterozygous mutations in the glucokinase. Linkage of MODY to the Arg85Trp GCK mutation, among Algerian diabetic patients has been established in our previous research. The … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,811 accessesView PDFCite
Review ArticleOpen accessIn the abstractA Review on the Genetic Regulation of Myogenesis and Muscle DevelopmentWuyi LiuMyogenesis of muscle tissues is known as a very complex and delicate process including many cellular differentiation and development events in animals. Here, the courses of cellular fate determination and terminal differentiation of muscle cells are systematically elaborated and the genetic regulatory network of muscle genesis is well conceived in animal organic growth and development through literature retrieval. Furthermore, the … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 1 · 7 Mar 2019 · 9,618 accessesView PDFCite
Research ArticleOpen accessIn the abstractSome Morphologic Features of Heart Failure with Different EtiologyDmitrij Arkadievich OleynikovDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying doxorubicin-induced cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. The study population consisted of 46 dogs of different age, sex … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 20 May 2017 · 7,334 accessesView PDFCite
Research ArticleOpen accessIn the abstractMetabolic Features of Heart Failure with Different EtiologyOleynikov Dmitrij ArkadievichDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying Doxorubicin-induced Cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. In this study we investigate several metabolic features of doxorubicin-induced cardiomyopathy, … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 9 Mar 2017 · 7,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Galactomannan Extracted from Iraqi Lycium barbarum L. Fruits against Alloxan-Induced Diabetes in RatsAdnan J.M. Al-FartosyLycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 15 Dec 2014 · 7,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractCinnamon Extract Regulates Gene Expression of Lipid and Carbohydrate Metabolism in Streptozotocin Induced Diabetic Wistar RatsMohamed Mohamed Soliman, Mohamed Mohamed Ahmed, Samir Ahmed El-ShazlyCinnamon is a herbal medication plant used widely for many diseases in the Middle East and ancient countries. Cinnamon Extract (CE) contains many active substances that modulate insulin sensitivity and acts as anti-diabetic medication. Diabetes mellitus is a disease characterized by disturbance in carbohydrate and lipid metabolism. The aim of this study was to examine the effect of Cinnamon Extract … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 8,048 accessesView PDFCite