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82 articles for “AIDS”
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Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,193 accessesView PDFCite
Research ArticleOpen accessIn the abstractSecurity Challenges in Multicast Communication for Mobile Ad Hoc NetworkS. Gunasekaran, K. DuraiswamyProblem statement: Multicasting communication network accepted a single message from an application and delivered copies of the message to multiple recipients at different locations. Recently, there has been an explosion of research literature on multicast communication environment. The objective of this study were to contribute the complexity of supporting current multicast applications, (i) the lack of reliable multicast transport mechanisms … …Journal of Computer Science, Vol. 6, Issue 5 · 31 May 2010 · 6,126 accessesView PDFCite
Research ArticleOpen accessIn the abstractWork Posture and Back Pain Evaluation in a Malaysian Food Manufacturing CompanyBaba Md. Deros, Dian Darina Indah Daruis, Ahmad Rasdan Ismail, Ahmad Rifqi Abdul RahimProblem statement: A cross-sectional study was conducted among workers at a processed food manufacturer in Malaysia. The main objective of the study was to determine the prevalence of back pain among workers who perform manual material handling. In addition, the study also investigated the effectiveness of the interventions provided by the employer to reduce the risk of back pain. Approach: … …American Journal of Applied Sciences, Vol. 7, Issue 4 · 30 Apr 2010 · 7,561 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Severity of Mitral Valvular Regurgitation with Doppler Echocardiography Using Proximal Flow Convergence MethodPinjari Abdul Khayum, M.N. Giriprasad, P.V. SrideviProblem statement: Valvular regurgitation is recognized as the central cause of morbidity and mortality. Even though the clinician can detect the presence of regurgitation by mere physical examination; diagnostic methods become inevitable while estimating the severity of valvular regurgitation and in the transformation of cardiac chambers as in reaction to the volume overload condition. Lately, a promising new technology, the … …Journal of Computer Science, Vol. 5, Issue 2 · 28 Feb 2009 · 7,223 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Changes of Some Electrolytes after Two Months ActivityM. J. Pourvaghar, A. R. ShahsavarSome investigators have speculated that sodium chloride losses in sweat associated with net dehydration may lead to the observed hyponatremia after prolong strenuous exercise. The effects of altered hydration can influence athletes cognitively in addition to physically. In this research, rest alterations of sodium and potassium of blood serum have been investigated. The subjects were male students who have been … …Journal of Social Sciences, Vol. 4, Issue 4 · 31 Dec 2008 · 7,937 accessesView PDFCite
Research ArticleOpen accessIn the abstractCocaine: A Catalyst for Human Immunodeficiency Virus-Associated DementiaNavneet K. Dhillon, Milind Gadgil, Andy Rahardja et al.Injection drug use has been recognized as a major risk factor for AIDS from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States can both impair the functions of macrophages and CD4+ lymphocytes and also activate HIV-1 expression in these cells. Cocaine is a multifactorial agent that acts globally to impair the … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,590 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancer may be caused by the Immune ReactionRichmond T. PrehnHormesis-like effects of immunity have been documented during tumor-growth experiments in mice, quantitatively large immune-reactions have inhibited while lesser quantities of the same specific immune-reactants have been stimulatory to the growth of implanted tumors. Likewise, carcinogenesis has been inhibited by a high quantities of immune reactants, but positively stimulated by lower levels of the same reactants. One observation suggests that … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,462 accessesView PDFCite
Research ArticleOpen accessIn the abstractApplications of Real-time Reverse Transcription Polymerase Chain Reaction in Clinical Virology Laboratories for the Diagnosis of Human DiseasesR. Manojkumar, V. MrudulaEarly diagnosis that prevents further expansion of the causative agent and thereby aids control and eradication of infectious agents is critical for countries trying to obtain a particular disease free status. In these diagnostics speed is paramount, including the assay’s applicability, sensitivity, specificity, cost effectiveness and patentability. Real-time Reverse Transcription PCR (rRT-PCR) has revolutionized the field of molecular biology and … …American Journal of Infectious Diseases, Vol. 2, Issue 4 · 31 Dec 2006 · 6,557 accessesView PDFCite
Research ArticleOpen accessIn the abstractMetabolic Abnormalities Associated with the Use of Protease Inhibitors and Non-nucleoside Reverse Transcriptase InhibitorsMadhu N. Rao, Grace A. Lee, Carl GrunfeldThe use of protease inhibitors and non-nucleoside reverse transcriptase inhibitors for the treatment of HIV infection and AIDS has been associated with multiple abnormalities in glucose and lipid metabolism. Specifically, these abnormalities include insulin resistance, increased triglycerides and increased LDL cholesterol levels. The metabolic disturbances are due to a combination of factors, including the direct effect of medications, restoration to … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,941 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Changing Pathology of NeuroAIDS Associated with Drug Abuse in the Era of HAARTE Bell Jeanne, C. Anthony Iain, Simmonds PeterCompliance with highly active antiretroviral therapy (HAART) arrests HIV induced immune collapse and reduces the prevalence of severe central nervous system (CNS) complications, including HIV associated dementia and encephalitis. However minor cognitive disorders remain common and recent autopsy studies have demonstrated the presence of subtle neuropathological abnormalities in HAART treated individuals, including persistent neuroinflammation and enhanced deposition in the brain … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,874 accessesView PDFCite