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228 results for “toxicity”
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Research ArticleOpen accessIn the keywordsParacetamol: A Focus on DogsCharbel Fadel, Irene Sartini, Mario GiorgiParacetamol (APAP) is an aniline analgesic, antipyretic and non-narcotic. It is an essential drug, widely used in human medicine. In veterinary medicine it has an extra label use in many countries. It is used exclusively in some animals, including dogs. It has a mechanism of action similar to that of NSAIDs, as well as other unique characteristics. A variety of … …American Journal of Animal and Veterinary Sciences, Vol. 16, Issue 4 · 2 Nov 2021 · 11,585 accessesView PDFCite
Research ArticleOpen accessIn the keywordsToxicological Study of Hydroalcohol Leaf Extract of Acanthospermum hispidum (Asteraceae)Diallo Aboudoulatif, Dowou Salem, Badjabaissi Essotolom et al.Acanthospermum hispidum is a widely plant used in African traditional medicine. This study aims to assess cardiotoxicity and sub-chronic (28-days) oral toxicity of hydroalcohol leaf extract of A. hispidum. The sub-chronic toxicity was evaluated after administering daily oral doses of 500 and 1000 mg/kg body wt., for 28 days to the rats, biochemical and haematological assessments as well as body … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 16 Mar 2020 · 7,755 accessesView PDFCite
Research ArticleOpen accessIn the keywordsToxicology of Nanomaterials on ZebrafishJimmy De León, María del C. Cotto, Francisco MárquezIncreases in the use and the progressive manufacture of new Engineered Nanomaterials (ENMs) lead to inquire about their impact on the environment. Due to the small size, high reactivity inside organisms and the unusual physicochemical properties of the ENMs, the predictions of toxicity are very complex. The zebrafish (Danio rerio) has been granted as a practical alternative to study the … …American Journal of Engineering and Applied Sciences, Vol. 12, Issue 2 · 29 May 2019 · 7,784 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHigh Level of Nicotianamine Synthase (NAS3) and Natural Resistance Associated Macrophage Protein (NRAMP4) Gene Transcription Induced by Potassium Nitrate in Trembling Aspen (Populus tremuloides)Karolina M. Czajka, Kabwe NkongoloChanges in gene transcription in response to excess metal concentrations have been reported in many organisms, including yeast, microorganisms and plants. Most investigations on the effects of nickel toxicity in plants use commercial salts whose effects have not been analyzed in detail. The main objective of the present study was to determine the effects of different doses of nickel nitrate … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 3 · 15 Jul 2018 · 10,884 accessesView PDFCite
Review ArticleOpen accessIn the keywordsEnvironmental Concerns and Toxicogenetic Endpoints of Priority Substances (PSs) and Contaminants of Emerging Concerns (CECs): A Comprehensive ReviewDe-Sheng Pei, Chun-Di Chen, Naima Hamid et al.Priority Substance (PSs) and Contaminant of Emerging Concerns (CECs) exhibited a wide range of environmental and public health concerns worldwide. This review summarized the documented studies related to the current surface water occurrence, spatial distribution, ecological risks and toxicity of selected PSs, such as polycyclic aromatic hydrocarbons (PAHs) and CECs, such as Di(2-Ethylhexyl) Phthalate (DEHP) and Pharmaceuticals and Personal Care … …American Journal of Environmental Sciences, Vol. 14, Issue 3 · 10 Jul 2018 · 8,389 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHost Plant-Induced Susceptibility of Two-Spotted Spider Mite Tetranychus urticae (Acari: Tetranychidae) to Some Reduced-Risk AcaricidesTarikul IslamThe two-spotted spider mite Tetranychus urticae (Acari: Tetranychidae) is a cosmopolitan pest of a large number of host plants having extensive damage potential and the terrific ability of pesticide resistance. In the present study, spider mite population were reared continuously on the leaves of three susceptible host plants namely country bean (Phaseolus vulgaris L), papaya (Carica papaya L) and jute … …American Journal of Agricultural and Biological Sciences, Vol. 14, Issue 1 · 14 Apr 2018 · 9,338 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntimicrobial and Antioxidant Activities of Bacterial Extracts from Marine Bacteria Associated with Sponge Stylotella sp.Daning Yoghiapiscessa, Irmanida Batubara, Aris Tri WahyudiSponge-associated bacteria have great potential in developing marine pharmaceutical industry since they are capable of synthesizing numerous bioactive metabolite compounds. This study aimed to isolate, characterize and investigate potential antimicrobial, toxicity and antioxidant of bioactive compounds of bacteria associated with sponge Stylotella sp. A total of 138 bacteria were selected. During screening stage, 45 isolates (32%) produced a wide spectrum … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 1 · 22 Feb 2016 · 9,154 accessesView PDFCite
Research ArticleOpen accessIn the keywordsECOTOXICOLOGICAL BIOASSAYS OF THE EARTHWORMS ALLOLOBOPHORA CALIGINOSA SAVIGNY AND PHERETIMA HAWAYANA ROSA TREATED WITH ARSENATEAbdelmonem Mohamed KhalilLittle research has been carried out on the effect of arsenate on earthworms. Ecotoxicological laboratory tests are fundamental tools for assessing the toxicity of arsenate to soil organisms. In this study, the impact of arsenate on the survival, reproduction and behaviour of the endogenic earthworms Allolobophora caliginosa and the anecic earthworms Pheretima hawayana has been quantified. The 96-h LC 50 … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 27 Sep 2013 · 7,068 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCombined Chelation Therapy with Deferasirox and Desferrioxamine In Removing Lead from RatsFaezeh Dahooee Balooch, Seyed Jamilaldin Fatemi, Marzieh Iranmanesh, Batool HosseinkhaniThe present study aimed to evaluate the potential efficiency of Deferasirox (DFX) and Desfferioxamine (DFO) as chelating agents in removing lead from rats as a biological model. Two different doses of lead (II) chloride (40 and 80 mg kg-1 body weight) were used for 45 days. After this period, all rats showed toxicity symptoms through loss of hair, greenish mottling … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 24 Sep 2013 · 7,151 accessesView PDFCite