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72 articles for “oral administration”
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Research ArticleOpen accessIn the abstractEffect of Dietary Kaempferia parviflora on Ischemic Brain Injury in the ratWathita Phachonpai, Sinthuporn Maharun, Supaporn Muchimapura et al.Problem statement: Stroke often causes irreversible neuronal damage and related behavioral deficits. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional plant medicines. We investigated the ability of consuming Kaempferia parviflora extract, a Thai medicinal plant reputed for neuroprotective effects against brain damage, reduced infarct volume and improve neurological … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 20 Mar 2012 · 9,095 accessesView PDFCite
Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,881 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Hydro-Alcoholic Extract of Cucurbita Maxima, Fruit Juice and Glibenclamide on Blood Glucose in Diabetic RatsV. K. Lal, P. P. Gupta, Awanish Pandey, P. TripathiProblem statement: Cucurbita maxima has been used traditionally in Mexico, China and India as antidiabetic agents. Approach: The present study was to evaluate the hypoglycemic activity of fruit juice and hydro-alcoholic extract of Cucurbita maxima for validation of its folkloric use. Results: Hypoglycemic activity was evaluated on streptozotocin induced diabetic rats at the doses of 100 and 200 mg kg-1 … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 26 Nov 2011 · 8,284 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vitro and In Vivo Anticancer Activity of Bacoside A from Whole Plant of Bacopa Monnieiri (Linn)N. S. Prakash, R. Sundaram, S. K. MitraProblem statement: Natural products have long been a fertile source of cure for cancer, which is projected to become the major cause of death in this century. Major classes of anticancer compounds include alkaloids, terpenoids, flavonoids and lignans. We have chosen terpenoids (bacosides) because terpenoids like taxol are currently being used in cancer chemotherapy. The anticancer activity of Bacoside A … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 9,668 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,686 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon ExtractMohamed H. Mahfouz, Hala M. Ghanem, Mona A. MohamedCinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 7,814 accessesView PDFCite
Research ArticleOpen accessIn the abstractPerformance of Pre-Weaned Dairy Calves under Hot Arid Environment: Effects of Immunoglobulins and Age on Diseases and MortalityM. A. Razzaque, T. Al-Mutawa, S. Abbas, M. BedairProblem statement: A high mortality rate (crude mortality 43.6%) of pre-weaned dairy calves resulted in unavailability of replacement heifers in Kuwait. Dairy producers resorted to import pregnant heifers for herd replacement. This study was undertaken to investigate the effects of dam vaccination and age, serum Immunoglobulin (Ig) on disease syndromes and mortality in pre-weaned calves. Approach: Late pregnant Holstein Friesian … …American Journal of Applied Sciences, Vol. 6, Issue 11 · 30 Nov 2009 · 7,560 accessesView PDFCite
Research ArticleOpen accessIn the abstractCytoprotective Effect of UlGen, a Polyherbal Formulation against Physical and Chemical Factor Induced Gastric Ulcers in Wister Albino RatsT. S. Muralidhar, Anna Balaji, Chinmay Bandopadhyay, S. L. ShanthaProblem statement: UlGen, a Polyherbal formulation, was investigated for its possible Ulcero-protective activity in ulcerogen and Cold-restraint stress induced Wister rats (Rattus rattus). Oral administration of UlGen, at a dose of 800 mg kg-1 significantly protected the onset of cold-resistance stress induced ulcerations. Approach: It significantly inhibited gastric ulceration induced by alcohol and aspirin. Control group: Alcohol 80% induced ulcer … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 8,182 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Acute Administration of Artemisia Persia Extracts on Arterial Blood Pressure and Heart Rate in RatsFarzaneh Esmaeili, Gholamreza Sepehri, Ghollam-Reza Moshtaghi-Kashanian et al.Problem statement: Artemisia Persia (AP) used for its therapeutic effects in folk medicine whiles some species of Artemisia shown a hypotensive effect. To determine the cardiovascular effect of AP, we tested the pharmacological responses of aqueous and methanolic extracts of AP on blood pressure (BP) and Heart Rate (HR) of normotensive and ephedrine induced hypertensive rats using a tail-cuff computerized … …American Journal of Applied Sciences, Vol. 6, Issue 5 · 31 May 2009 · 7,659 accessesView PDFCite
Research ArticleOpen accessIn the abstractAqueous Extract of Inonotus bliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing ApoptosisCaifa Chen, Weifa Zheng, Xiaowen Gao et al.Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) has been widely used as a folk medicine to treat various cancers in Russia, Poland and most of Baltic countries for literally more than four centuries. However, in spite of its therapeutic significance for cancers, this fungus has not been studied systematically for the mechanisms of antitumor activity. In this study, we report the effects … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 21,115 accessesView PDFCite