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84 results for “mouse”
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Research ArticleOpen accessIn the abstractPhysiological Effects of a Combination of Cinnulin with ProbioticsVetvicka Vaclav, Vetvickova JanaThe search for an optimal combination of natural immunomodulators led us to study the biological effects of the combination of a cinnamon extract Cinnulin PF and probiotic LactoSpore. We found that this combination has strong synergetic effects on phagocytosis and on regulation of cholesterol and blood sugar levels. In addition, the Cinnulin/LastoSpore combination also reduced intestinal damage in mouse model … …American Journal of Immunology, Vol. 9, Issue 4 · 2 Oct 2013 · 8,222 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessment of Immunogenicity of CP8, CLFA-FnBPB and CP8-CLFA-FnBPB AntigensXiuli Liu, Yongqing Hao, Shuyi Wang et al.To assess the effects of conjugating Capsular Polysaccharide (CP) with Clumping factor A (ClfA) and Fibronectin-Binding Proteins B (FnBPB) on the immunogenicity of the antigen, CP was isolated and purified from serotype 8 (CP8) Staphylococcus aureus from bovine mastitis dairy herds in Inner Mongolia and ClfA-FnBPB was produced with Escherichia coli encoding a fusion protein ClfA-FnBPB gene. The CP8-ClfA-FnBPB complete … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 3 · 30 Aug 2013 · 7,545 accessesView PDFCite
Research ArticleOpen accessIn the abstractLike an Invertebrate Primitive AntibodyMichel LeclercSpecific immune responses occur in an invertebrate: The sea star Asterias rubens. Sea star T and B lymphocytes are present in the axial organ and coopere with phagocytes and Complement components to produce a primitive antibody correlated to Igkappa genes and to complement genes: It could be composed of 4 kappa chains and present strong and highly significant homologies to … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 7,043 accessesView PDFCite
Research ArticleOpen accessIn the abstractAroclor 1254 Toxicity to Mice Liver Membrane AtpasesShweta Pathak, Rahul KunduPresent communication reports the sub-acute dose and exposure duration dependent effects of Aroclor 1254 on total, Na+, K+, Ca++ and Mg++-ATPases of the mouse liver cells. The study tests two hypotheses, (a) whether the sublethal dose or the exposure duration dependent in vivo exposure of hydrophobic PCB (Aroclor 1254) affects the hydrophilic membrane-bound ion dependent ATPases of the liver cells … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 13 Jul 2013 · 6,791 accessesView PDFCite
Research ArticleOpen accessIn the abstractVoice Activation Visualization for Echocardiograph and 3D Angiographic Images in SurgeryRahmita W. Rahmat, Mohd Z. Dimon, Zinah R. Hussein, Hasan H. KhalilIn some cases, surgeons need to navigate through the computer system for reconfirmation patients’ details and unfortunately surgeons unable to manage both computer system and operation at the same time. In this paper we propose a solution for this problem especially designed for heart surgeon, by introducing voice activation system with 3D visualization of Angiographic images, 2D visualization of Echocardiography … …Journal of Computer Science, Vol. 8, Issue 11 · 9 Oct 2012 · 8,293 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancerous Immunoglobulins and CA215: Implications in Cancer ImmunologyGregory LeeImmunoglobulins are typically expressed by B cells in our normal immune system. However, certain normal human tissues, such as hyperplastic epithelial cells, cells of the immunologically privileged sites and the majority of cancer cells, have also been found to be sites of immunoglobulin production. Current research is lacking in regards to the differential immunoglobulin expression, the underling mechanisms of action … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Sep 2012 · 8,942 accessesView PDFCite
Research ArticleOpen accessIn the abstractInnate and Adaptative Immunity in the Sea-Star Asterias RubensMichel LeclercThe axial organ of the sea star Asterias rubens is a primitive immune organ. The B-like cells, when stimulated by various antigens, produce antibody substances correlating with Mouse Ig Kappa genes. On the other hand elements of the innate immunity are present in Asterias rubens such as Toll-like receptors, interleukin receptors, complement components which contribute to initiate the «antibody factor». …American Journal of Immunology, Vol. 8, Issue 3 · 1 Sep 2012 · 7,903 accessesView PDFCite
Research ArticleOpen accessIn the abstractMonoclonal Antibody-Based Therapeutics for Melioidosis and GlandersHyung-Yong Kim, Alexander Stojadinovic, Peter J. Weina et al.Problem statement: Burkholderia Pseudomallei (BP) and B. Mallei (BM) were two closely related pathogenic gram-negative bacteria. They were the causative agents of melioidosis and glanders, respectively and are recognized by CDC as category B select agents. Significant efforts had been devoted to developing the diagnostic and therapeutic measures against these two pathogens. Monoclonal antibody-based therapeutic was a promising targeted therapy … …American Journal of Immunology, Vol. 7, Issue 3 · 23 Dec 2011 · 8,975 accessesView PDFCite
Research ArticleOpen accessIn the abstractPalmitate-Induced Translocation of Caveolin-3 and Endothelial Nitric Oxide Synthase in CardiomyocytesCatherine J. Knowles, Megan Dionne, Martina Cebova, Ilka M. PinzProblem statement: Palmitate is a known cardiac lipotoxin that blunts cardiomyocyte contractile function and induces apoptosis, likely via accumulation of the lipotoxic ceramide. Ceramide is a sphingolipid and localizes to caveolae, which are lined in the inner membrane leaflet by caveolin proteins. In this study, we investigated the effects of palmitate on caveolin proteins and on endothelial Nitric Oxide Synthase … …OnLine Journal of Biological Sciences, Vol. 11, Issue 2 · 27 Aug 2011 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDFCite