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78 results for “dysfunction”
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Research ArticleOpen accessIn the abstractS-Allyl-Cysteines Reduce Amelioration of Aluminum Induced Toxicity in RatsSadhana ShrivastavaProblem statement: Aluminum (Al) is a trivalent cation found in its ionic form in most kinds of animal tissues and in natural waters everywhere. Approach: It is a potent neurotoxin and has been associated in the pathogenesis of several clinical disorders including Alzheimer’s disease. Results: The aim of the study was to demonstrate the protective effect of S-Allyl-Cysteines (SAC) against … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 12 Aug 2011 · 7,748 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino MiceMohamed E.M. AfifiProblem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Crude Oil and Spent Oil on Clarias garipinus: A Typical Marine FishA. M. Gbadebo, A. M. Taiwo, O. B. OlaProblem statement: Petroleum hydrocarbon and petroleum residue (i.e., spent oil) remains the foremost pollutants to the fish communities in various aquatic media-ponds, streams, rivers, creeks, coastal and marine environments through indiscriminate disposal of oil contaminated drilling muds, cutting and oil spillages. Approach: Also, the spent oil enters into aquatic media through run-off following unguided disposal. Both the petroleum hydrocarbon and … …American Journal of Environmental Sciences, Vol. 5, Issue 6 · 31 Dec 2009 · 7,467 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Antidiabetic Efficacy of Combined Extracts from Two Continental Plants: Azadirachta indica (A. Juss) (Neem) and Vernonia amygdalina (Del.) (African Bitter Leaf)Patrick Ekong Ebong, Item Justin Atangwho, Eyong Ubana Eyong, Godwin Eneji EgbungPolyherbal therapy is said to be a current pharmacological principle having the advantage of producing maximum therapeutic efficacy with minimum side effects. We assessed the antidiabetic efficacy and hence the impact on biochemical indices of toxicity by a combination of extracts from neem and bitterleaf. Thirty rats, 25 diabetic and 5 non-diabetic rats, were used for the study. The diabetic … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 3 · 31 Aug 2008 · 14,400 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,507 accessesView PDFCite
Research ArticleOpen accessIn the abstractBridging from Cells to Cognition in Autism Pathophysiology: Biological Pathways to Defective Brain Function and PlasticityMatthew P. Anderson, Brian S. Hooker, Martha R. HerbertWe review evidence to support a model where the disease process underlying autism may begin when an in utero or early postnatal environmental, infectious, seizure, or autoimmune insult triggers an immune response that increases reactive oxygen species (ROS) production in the brain that leads to DNA damage (nuclear and mitochondrial) and metabolic enzyme blockade and that these inflammatory and oxidative … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 17,455 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetection of IL-17 and IL-23 in Plasma Samples of Children with AutismAmanda Enstrom, Charity Onore, Irva Hertz-Picciotto et al.Interleukin-23 (IL-23) is a survival factor for a newly described population of T lymphocytes, namely Th-17 cells, that secrete IL-17, tumor necrosis factor- alpha (TNFα) and IL-6. It has been shown that Th-17 cells are a pathogenic T cell subset involved in autoimmune and chronic inflammatory diseases. Based on the increasing evidence of immune dysfunction in autism, including possible autoimmune … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,223 accessesView PDFCite
Research ArticleOpen accessIn the abstractPathophysiology of Adipocyte Defects and Dyslipidemia in HIV Lipodystrophy: New Evidence from Metabolic and Molecular StudiesAshok Balasubramanyam, Rajagopal V. Sekhar, Farook Jahoor et al.Despite a burgeoning mass of descriptive information regarding the epidemiology, clinical features, body composition changes, hormonal alterations and dyslipidemic patterns in patients with HIV lipodystrophy syndrome (HLS), the specific biochemical pathways that are dysregulated in the condition and the molecular mechanisms that lead to their dysfunction, remain relatively unexplored. In this paper, we review studies that detail the metabolic basis … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,608 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuroendocrine Abnormalities in Drug Abusers and HIV-Infected Individuals: Cortisol Response to Cold Pressor ChallengeMahendra Kumar, Drenna Waldrop-Valverde, Adarsh M. Kumar et al.Although endocrine abnormalities have been reported in HIV-1 infection, the role of risk factors is not understood. Injecting drug use (IDU) is an important risk factor for contracting HIV-infection and studies suggest that substance use may also be associated with endocrine dysfunction. In order to investigate hypothalamic pituitary adrenal (HPA) axis activity in this population, this study investigated cortisol response … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,594 accessesView PDFCite
Research ArticleOpen accessIn the abstractRecreational Viagra Use and Sexual Risk among Drug Abusing MenDennis G. Fisher, Robert Malow, Rhonda Rosenberg et al.Until recently, the Viagra connection to HIV was anchored in older adults. However, CDC investigation showed stability in 50+ HIV diagnoses on the heels of upward trends in risk indicators among men who have sex with men (MSM) and substance abusing populations. Signs have increasingly pointed to recreational drug use among younger populations, to which Viagra is being added to … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 10,605 accessesView PDFCite