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72 articles for “drug development”
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Research ArticleOpen accessIn the abstractVoluntary Counseling and Testing with AIDS Outpatient: Hubei, ChinaSheng Wanxiang, Liu Xiaoming, Yang Rongrong et al.The HIV/AIDS epidemic has affected the world over the past two decades reveals the significant role of socio-cultural beliefs and attitudes in the shaping of people’s lifestyles and approaches to the control and prevention of epidemics. A descriptive analysis of Voluntary Counseling and Testing (VCT) in the 2005-2006 which is the key Hubei provincial science and technology project that studies … …American Journal of Infectious Diseases, Vol. 3, Issue 1 · 31 Mar 2007 · 7,070 accessesView PDFCite
Research ArticleOpen accessIn the abstractRetinoids Chemosensitize Ovarian Cancer Cell Lines to Cisplatin Independent of Nuclear Receptors and p53Suresh Guruswamy, Doris M. BenbrookTreatment of ovarian cancer with cisplatin-based chemotherapy is highly toxic and is often followed by cancer recurrence. Repeated treatments with cisplatin frequently result in the development of resistance to this drug. Drugs with low toxicity that could enhance the tumor cell killing effects of cisplatin could potentially reduce the toxicity and enhance the efficacy of cisplatin. The mechanism of cell … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,962 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordThe Development of New Molecules Having Antiemetic Activity Using Molecular ModelingKhalil Errahmane Kanouni, Yacine BenguerbaThe solubility of a drug in water or in the blood represents the most desired parameter in medicine. Our aim is to obtain molecules with properties more effective than those of metoclopramide. In this work, two molecules with high solubility are constructed. Metoclopramide (a benzamide derivative) is a dopamine receptor antagonist used as an antiemetic drug. Its solubility in water … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,670 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordPrevalence and Determinants of Antibiotic Use by the Elderly in Marrakech, MoroccoNaima Aoutil, Mohamed Cherkaoui, Mohamed BouskraouiAntibiotics are essential for the prevention and treatment of bacterial infections; however, their inappropriate use among elderly populations poses serious risks, including the emergence of multidrug-resistant organisms. Antimicrobial resistance has become a critical global public health challenge, with irrational antibiotic use being one of its primary drivers. In Morocco, data on antibiotic use among older adults remain scarce, particularly regarding … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 13 Apr 2026 · 1,370 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDevelopment of Curcumin Based Ophthalmic FormulationD. Anjana, K. Anitha Nair, N. Somashekara et al.Problem statement: Ophthalmic drug delivery system has been a major challenge due to the distinctive and unique anatomy of the eye. The use of phytochemicals for the application in ocular disease has not been investigated much, due to poor pharmacokinetics of phytochemical and hence poor therapeutic efficacy. Approach: Curcumin is one such phytochemical known for its medicinal properties, but its … …American Journal of Infectious Diseases, Vol. 8, Issue 1 · 24 Feb 2012 · 15,409 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,110 accessesView PDFCite
Short CommunicationsOpen accessAll words, across the recordCytotoxicity and Apoptosis-Induction Potential of Fraction F3 from Fruits of Bersama engleriana (Melanthaceae) against Human Cervical Cancer CellsMichèle Stella Majoumouo et al.Cervical cancer is one of the most life-threatening malignancies worldwide, despite intensive research for more efficacious chemotherapeutic agents. Recent efforts geared towards eradicating the scourge of cancer have embodied a major surge of interest in natural products as promising lead molecules in pharmaceutical development and therapeutic translation. Consequently, this study aimed to assess the cytotoxicity of a previously identified plant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,294 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDevelopment of Improved Preventive and Treatment Strategies for Controlling of Toxoplasmosis in Saudi ArabiaAlaa B. Ismael, Ayman A. Swelum, Mohammed A. NassanToxoplasmosis causes severe public health problems and has great veterinary and economic importance worldwide. The present study aims mainly to develop an improved preventive and treatment program for controlling toxoplasmosis in sheep and goats. This study was performed on sheep and goats farm containing 357 animals (300 sheep and 57 goats). This farm had a large numbers of barren ewes, … …American Journal of Infectious Diseases, Vol. 12, Issue 2 · 14 Jun 2016 · 7,735 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDevelopment of a Short-Term Canine Full-Thickness Skin Organ Culture Method under Serum-Free ConditionsFrancesca Abramo, Andrea Pirone, Carla Lenzi et al.Full-thickness canine skin organ culture models could provide an entirely new opportunity for studying wound healing, keratinization disorders and allergic skin diseases, all of which have high prevalence and severe impact on canine quality of life. Here we present a canine organ culture method for the short-term maintenance of full-thickness, adult, canine skin in serum-free medium and investigate the possibility … …American Journal of Animal and Veterinary Sciences, Vol. 11, Issue 2 · 13 Jun 2016 · 7,383 accessesView PDFCite
Review ArticleOpen accessAll words, across the recordHerbal Compounds-An Alternative for Multi-Drug Resistant Vibrio CholeraeSabah Perveen, Hotam Singh ChaudharyVibrio cholerae is a causative agent of cholerae, many people dies every year, especially in developing countries around the world. The outbreaks of cholera are responsible for approximately 120,000 deaths annually. Cholera is a self limiting illness; however antibiotics are used as a part of treatment regimen. But at present, the treatment against cholera has become very critical issue worldwide, … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 12 Oct 2015 · 7,261 accessesView PDFCite