Research ArticleOpen accessIn the abstractCancer Chemotherapy and Immune RegulationJohn Barrett, Katarina Le BlancProblem statement: Chemotherapeutic drugs have been used to treat malignancy for over 50 years, but the potential of cytotoxic agents to suppress immunity and interfere with Immunosurveillance (IS) of cancer has been largely ignored. Assuming that the immune control of the cancer had a priori already failed, the effect was not considered to have a major impact on treatment outcome. … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 40,663 accessesView PDFCite
Research ArticleOpen accessIn the abstractHybrid Ceramo-Polymeric Nano-Diamond CompositesAntonio Apicella, Raffaella Aversa, Florian Ion Tiberiu PetrescuThis paper discusses a new class of bio-mechanical scaffolds active for tissue engineering based on a nano-diamond-filled hydrophilic polymer matrix. The new biomaterials used have special mechanical and biological properties for which they should be extensively studied for their use for various advanced biomedical applications. The new hybrid material has been prepared using 2 and 5% by volume of detonating … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 2 · 21 May 2018 · 8,616 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,507 accessesView PDFCite