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98 articles for “Protein Structure”
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Research ArticleOpen accessIn the abstractAnticancer Activities of Styrylpyrone from the Leaves and Twigs of Goniothalamus maewongensis via Cell Cycle ArrestPradit Pradupsri, Chatchanok Loetchutinat, Narong Nuntasaen et al.Problem statement: Goniothalamus maewongensis is one of three new species which are found in Thailand recently. The genus goniothalamus is not only well known for the rich of styrylpyrones but also famous for the potential of biological activities, especially the cytotoxic activity against a number of human cancer cell lines. The phytochemical and biological investigations of this plant are interesting … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,195 accessesView PDFCite
Research ArticleOpen accessIn the abstractTarget Identification in Ory S1 Pollen Protein Allergen from Oryza sativa in the Course of Construction of Hypoallergenic VaccinesRuchi Sharma, A. K. SinghProblem statement: Recombinant-based approaches are mostly focused on genetic modification of allergens to produce molecules with reduced allergenic activity and conserved antigenicity, such as hypoallergens. Recombinant allergens represent promising tools for diagnosis and therapy of type I allergy. This approach was probably feasible with every allergen with known amino acid sequence. Approach: The primary aim of this study was to … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,444 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,579 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Survey of Protein Fold Recognition AlgorithmsMohammed Said Abual-Rub, Rosni AbdullahProblem statement: Predicting the tertiary structure of proteins from their linear sequence is really a big challenge in biology. This challenge is related to the fact that the traditional computational methods are not powerful enough to search for the correct structure in the huge conformational space. This inadequate capability of the computational methods, however, is a major obstacle in facing … …Journal of Computer Science, Vol. 4, Issue 9 · 30 Sep 2008 · 6,879 accessesView PDFCite
Research ArticleOpen accessIn the abstractSolving Protein Folding Problem using Elitism-Based Compact Genetic AlgorithmAmr Badr, Ibtehal M. Aref, Basma M. Hussien, Yosr EmanProteins are vital components of living cells. A number of diseases such as Alzheimer's, Cystic fibrosis and Mad Cow diseases are shown to result from misfunctioning of proteins. Problem statement: Protein folding problem is the process of predicting the optimal 3D molecular structure of a protein, or tertiary structure, which is an indication of its proper function. Approach: An enhancement … …Journal of Computer Science, Vol. 4, Issue 7 · 31 Jul 2008 · 6,861 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment of Deduced Protein Database Using Variable Bit Binary EncodingB. Parvathavarthini, B. Rajesh Kanna, L. RajeswarideviA large amount of biological data is semi-structured and stored in any one the following file formats such as flat, XML and relational files. These databases must be integrated with the structured data available in relational or object-oriented databases. The sequence matching process is difficult in such file format, because string comparison takes more computation cost and time. To reduce … …Journal of Computer Science, Vol. 4, Issue 6 · 30 Jun 2008 · 6,514 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic Triggers for Intervention in Aging, Disease and TraumaJoan Smith SonnebornHormesis refers to the ability of a chemical or physical agent to condition the physiological state of an organism to tolerate stress with low doses of otherwise harmful agents. Evolutionary evidence shows that the survival and longevity of species hinge on their optimal ability to resist stress challenge. Hormesis is a potent strategy to stimulate latent repair processes to tolerate … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,898 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification and functional characterization of a novel lysine-rich protein from Entamoeba histolyticaAlka Mehra, Sudha Bhattacharya, Alok BhattacharyaIn an attempt to understand the role of genes with no known function, in the protozoan parasite Entamoeba histolytica, an analysis of the proteome was carried out and a Lysine-Rich protein (KRP) was identified for further study. This protein has a modular structure with four domains and was found to be expressed and localized to the cell surface of E. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,709 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Murine Charged Multivesicular Body Protein 2A, CHMP2A Interacts with the 5' and 3' Terminal Regions of Dengue Virus Complementary Minus-strand RNASuchita Chaudhry, Sathyamangalam Swaminathan, Navin KhannaDengue (DEN) viruses, of which there are four distinct serotypes (DEN-1, -2, -3 and –4), belong to the Flaviviridae family. Their ‘plus’ sense RNA genomes contain Non-Translated Regions (NTRs) at their 5’ and 3’ ends. Replication of viral genomic RNA, which takes place in close association with host cell membranes, involves the initial synthesis of the complementary minus sense RNA … …American Journal of Infectious Diseases, Vol. 2, Issue 1 · 31 Mar 2006 · 7,317 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Meaning of a Redundant Codon: There is Protein Folding Information in Nucleic Acids in Addition to the Genetic CodeJan C. Biro, Josephine M.K. BiroAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, which is not represented by the known genetic code. Nucleic acid subsequences comprising … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 8,297 accessesView PDFCite