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167 articles for “Oxidative Stress”
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Research ArticleOpen accessIn the keywordsEvidence of Mitochondrial Dysfunction in Autism and Implications for TreatmentDaniel A. Rossignol, J. Jeffrey BradstreetClassical mitochondrial diseases occur in a subset of individuals with autism and are usually caused by genetic anomalies or mitochondrial respiratory pathway deficits. However, in many cases of autism, there is evidence of mitochondrial dysfunction (MtD) without the classic features associated with mitochondrial disease. MtD appears to be more common in autism and presents with less severe signs and symptoms. … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 16,389 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,518 accessesView PDFCite
Research ArticleOpen accessIn the keywordsA Microscopic Study of Language-Related Cortex in AutismEdith López-Hurtado, Jorge J. PrietoImpaired language function is a principle criterion for the diagnosis of autism. The present study of brain from age-matched autistic and control subjects compared brain regions associated with the production and processing of speech. Wernicke's area (Brodmann 22, speech recognition), Broca's area (Brodmann 44, speech production) andthe gyrus angularis (Brodmann 39, reading) from autistic subjects (7-44 years of age) and … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 8,547 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAltered Sulfur Amino Acid Metabolism In Immune Cells of Children Diagnosed With AutismJung H. Suh, William J. Walsh, Woody R. McGinnis et al.Autism Spectrum Disorder (ASD) is a behaviorally defined neurodevelopmental disorder whose etiology is poorly understood. Recent studies have shown that autistic children may be experiencing increased inflammation and oxidative stress. Altered immune regulation may be one contributing factor to inflammation and oxidative stress in autistic children. Sulfur amino acid (SAA) metabolism plays a critical role in regulating blood leukocyte functions … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 10,793 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRed-Cell Trace Minerals in Children with AutismJoan Jory, Woody R. McGinnisAbnormalities in mineral-dependent antioxidant enzymes in children with autism raise interest in the determination of trace mineral status in this population. A cross sectional investigation of red cell mineral levels was carried out among 20 children with autism and 15 controls. Children with autism demonstrated significantly lower red cell selenium (p<0.0006) and higher molybdenum (p<0.01) than the controls. There was … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,877 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSesame Oil As A Protective Agent Against Doxorubicin Induced Cardio Toxicity In RatKaneez F. Shad, Suhail Al-Salam, Alaaeldin A. HamzaThe therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 4 · 31 Dec 2007 · 7,672 accessesView PDFCite
Research ArticleOpen accessIn the keywordsHigh Concentrations of Glucose can Activate or Inhibit Human Erythrocyte Aminolevulinate Dehydratase in vitro Depending Exposure TimeJ. C. Soares, D. Gabriel, V. Folmer et al.Hyperglycemia can cause oxidative stress and inactivate susceptible enzymes. In the present investigation we examined whether short-term incubations (24 or 48 h) with high concentrations of glucose (10-200 mmol L-1) inhibit ALA-D from human erythrocytes. Incubations of erythrocytes for 24 h with glucose (10 up to 40 mmol L-1) resulted in an increase of δ-ALA-D activity (P<0,001). Incubations of erythrocytes … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,689 accessesView PDFCite
Research ArticleOpen accessIn the keywordsInfluence of Different Doses of Irradiation on Oxidant and Antioxidant Systems in the Brain of Guinea PigsYildiz Guney, Ayse Bilgihan, Ayse Hicsonmez et al.The purpose of this study was to establish the impact of oxidative stress in the damaged brain tissue, irradiated with two different dose levels, a single dose of 8 and 15 Gy. In addition, the histological findings caused by ionizing radiation in the early period was investigated. The levels of MDA, GSH, SOD, CAT, GSH-Px and selenium were estimated in … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,541 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPurification, Structural Characterization and Anti-Aging and Stress Activities of Cordyceps Mycelium Polysaccharides from Paecilomyces HepialiXiaokang Hu, Huixiu Ma, Guicai Chen et al.This study identified and characterized the bioactive polysaccharide components from Cordyceps mycelium powder (CMP) derived from Paecilomyces hepiali, evaluating their anti-aging and stress-protective activities. Initial screening using Drosophila melanogaster revealed that crude Cordyceps polysaccharides (CCP) exhibited comparable effects to CMP and Cordyceps aqueous extracts (CAE) on natural lifespan and UV stress resistance, suggesting CCP as the primary bioactive component. CCP … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 1,702 accessesView PDFCite
Research ArticleOpen accessIn the keywordsPhytochemical Content and Antioxidant Potential of Leaf Extract Berchermia discolour (Munie Tree) For Goats in The Limpopo Province, South AfricaMosima Molepo, Grace Manyelo, Busisiwe GunyaThe study aims to investigate the phytochemical content and antioxidant potential of leaf extract Berchermia discolour (Munie tree) for goats. Plant leaves were ground, and their powder was mixed with reagents and chemicals to attain the concentration level of phytochemicals and other bioactive compounds found in these plant's properties. Most of the phytoconstituents were present (shown by the change of … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 29 Mar 2025 · 5,365 accessesView PDFCite