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Research ArticleOpen accessEvery word in the titleImpact and Control of Drug Therapy Guidelines for Tumor Patients During the Novel Coronavirus Pneumonia EpidemicRazi Ahmed, Shafiza Mohd Shariff, Shahrinaz Ismail et al.Since December 2019, many unexplained viral pneumonia cases have been found in Wuhan City, Hubei Province, China. It was later confirmed that the outbreak's causative agent was a new coronavirus. The virus was temporarily named "2019-new coronavirus" (2019-nCoV) by the World Health Organization (WHO). The diseases caused by 2019-nCoV were called by the National Health and Health Commission of China … …Journal of Computer Science, Vol. 17, Issue 8 · 9 Sep 2021 · 6,688 accessesView PDFCite
EditorialOpen accessEvery word in the titleImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,164 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCirculation of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis Strains in MexicoCarlos A. Vazquez-Chacon, Armando Martinez-Guarneros, Susana Balandrano Campos et al.Emergence of Extensively Drug-Resistant (XDR) Tuberculosis (TB) is an important public health problem worldwide. In Mexico, the extent of circulation of XDR-TB strains is unknown. Here, the drug-resistance patterns of TB isolates collected in Mexico between 2006 and 2008 were analyzed. Among 137 TB isolates, (58%) were classified as MDR exclusively, (33%) were Pre-XDR and (9%) were assigned as XDR. … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 7,424 accessesView PDFCite
EditorialOpen accessEvery word in the titleAre Heat Shock Proteins Druggable Candidates?Tawanda Zininga, Addmore ShonhaiBanumathy, G., V. Singh, S.R. Pavithra and U. Tatu, 2003. Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. J. Biol. Chem., 278: 18336-18345. DOI: 10.1074/jbc.M211309200 Brehmer, D., S. Rudiger, C.S. Gassler, D. Klostermeier and L. Packschies et al., 2001. Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nature Structural Molecular … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 2 Dec 2014 · 8,171 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,510 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleNEWER DRUGS FOR VISCERAL LEISHMANIASIS: A REVIEWKrishna Pandey, Dharmendra Singh, Sanjiva Bimal et al.Visceral Leishmaniasis (VL) is one of the most neglected tropical diseases worldwide. The diagnosis and treatment of this disease is quite complex. Sodium Antimony Gluconate (SAG) which used to be a very effective treatment has now developed resistance and is potentially a cardio-toxic drug. Pentamidine has now been discarded because of adverse effect of diabetes mellitus. Amphotericin-B is an effective … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 5 May 2014 · 7,135 accessesView PDFCite
Research ArticleOpen accessEvery word in the titlePrevalence of Drug-Resistant Strains of Streptococcus Pneumoniae in AbakalikiIroha Ifeanyichukwu Romanus, Okafor Florence Njideka, Nwakaeze Emmanuel Amobi et al.Streptococcus pneumoniae is a major cause of illness such as pneumonia, meningitis, bacteremia and otitis media in children and the elderly. The emergence of drug-resistant strains threatens to complicate the management of these diseases. We conducted a hospital-based surveillance for drug-resistant Strep. Pneumoniae in outpatients with pneumococcal infection in Abakaliki Ebonyi State Nigeria. Between 2003-2005 from January through December, a … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 26 Nov 2012 · 7,680 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRelation between Macroscopic Binding Constant and the Anticancer Efficacy of the Bovine Serum Albumin-Quercetin Complex against Drug-Sensitive and Drug-Resistant CellsWinit Choiprasert, Chatchanok Loetchutinat, Nathupakorn Dechsupa, Samlee MankhetkornProblem statement: We have previously analyzed the interaction of BSA with flavonoids by using FRET. In this study, the role of BSA on increasing in solubility and on carrying the quercetin derivatives thus enhanced their anticancer efficacy against drug-sensitive and drug-resistant cells were conducted. Approach: The macroscopic (KD) and microscopic (kd) binding constant of the complexation and the cellular partition … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 May 2011 · 8,296 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleComparative Docking Analysis on Natural Compounds Versus a Synthetic Drug as a Therapeutic for Acquired Immuno Deficiency SyndromeSandhya R. Nair, R. Subhashini, B. ThiagarajanProblem statement: Acquired Immune Deficiency Syndrome (AIDS) is one of the worst pandemics affecting and spreading quickly all over the world with a high mortality rate. AIDS has been able to kill so many people due to the unique property of Human Immunodeficiency Virus (HIV) virus. It attacks the immune system of the victim there by not allowing the immune … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,325 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCognitive-Behavioral Stress Management Interventions for Ethnic-Minority HIV-Positive Alcohol/Drug Abusers in Resource Limited and Culturally Diverse CommunitiesRobert M. Malow, Rhonda Rosenberg, Jessy G. DévieuxThe article reports our intervention work with Alcohol and Other Drug Abusing (AOD) People Living With HIV (PLWH). Present research has involved adapting Cognitive Behavioral Stress Management (CBSM) and other strategies to improve quality of life and health outcomes for PLWH. Historically, CBSM has used relaxation and coping skills training to reduce negative mood and improve coping behaviors. The efficacy … …American Journal of Infectious Diseases, Vol. 5, Issue 1 · 31 Mar 2009 · 7,759 accessesView PDFCite