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Research ArticleOpen accessIn the abstractPharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Exposure to Various Durations of Light on Serum Insulin-Like Growth Factor-I in Prepubertal Holstein HeifersL.J. Spicer, B.A. Buchanan, L.T. Chapin, H.A. TuckerOur objective was to determine if prolonged exposure to various durations of light (i.e., photoperiod) would affect serum IGF-I concentrations in heifers. Thus, 16 Holstein heifers, 2 to 4 mo of age, were exposed during a 5-wk pretreatment period to 12 h of cool-white fluorescent light (L) at an intensity of 1200 lux and 12 h of dark (D). At … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Dec 2007 · 6,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Thioredoxin-Fusion Proteins of α-Gliadin, γ-Gliadin and Low Molecular Weight Glutenin, from Wheat Endosperm and their Domains in EnterobacteriaClaudia G. Benitez-Cardoza, Yves Popineau, Jacques GueguenWheat seed storage proteins play a determining role in the viscoelastic properties of wheat gluten. The genes encoding α-gliadin, γ-gliadin and Low Molecular Weight glutenin and their N-central-repetitive and C-terminal domains from wheat endosperm had been subcloned into a thioredoxin expression system (pET102/D-Topo) and produced as fusion proteins in E. coli. The expression levels for each of the proteins varied … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,746 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,230 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Motion of Partial System on Phase Plane and Determination of Stable Cutting RegionsFiras Al Qura'nTurning is one of the most efficient preferred and cutting processes currently known. It was a challenging task for researchers to study the different dynamic properties explores its special dynamical properties, including conditions that insure the stability of the cutting process and the associated nonlinear vibrations. The main goal of this study was to develop and study a simple model, … …American Journal of Applied Sciences, Vol. 4, Issue 1 · 30 Apr 2007 · 6,822 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Study of Morphological Structure, Phase Structure and Molecular Structure of Collagen-PEO 600K Blends for Tissue Engineering ApplicationN. F. Mohd Nasir, M. G. Raha, N. A. Kadri et al.A new material which is collagen/ poly (ethylene oxide) (PEO) blend was developed to determine its possibility as a promising material for tissue scaffold. PEO with average molecular weight of 600,000 and collagen originated from calf skin were dispersed in 0.1 M acetic acid to prepare a concentration of 1 wt% for PEO and 0.15 wt% for collagen. The collagen-PEO600K … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 7,422 accessesView PDFCite
Research ArticleOpen accessIn the abstractSurface Properties of Cell-treated Polyethylene TerephthalateBing Shi, Hong Liang, Thomas B. Kuhn, Lawrence K. DuffyThe materials used in artificial joints undergo degradation through fatigue and corrosive wear in human body. The lifetime for well-designed artificial joints like hip joints is at most 12 years and a patient will usually have two total joint replacements during his/her lifetime. Tissue engineering, an alternative to total joint implantation, is the replacement of damaged tissue with the tissue … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,704 accessesView PDFCite
Research ArticleOpen accessIn the abstractDC Motor Control Predictive ModelsRavinesh Singh, Godfrey C. Onwubolu, Krishnileshwar Singh, Ritnesh RamDC motor speed and position controls are fundamental in vehicles in general and robotics in particular. This study presents a mathematical model for correlating the interactions of some DC motor control parameters such as duty cycle, terminal voltage, frequency and load on some responses such as output current, voltage and speed by means of response surface methodology. For this exercise, … …American Journal of Applied Sciences, Vol. 3, Issue 11 · 30 Nov 2006 · 7,015 accessesView PDFCite
Research ArticleOpen accessIn the abstractStatic and Dynamic Mechanical Behavior of Hydroxyapatite-Polyacrylic Acid Composites Under Simulated Body FluidKalpana S. Katti, Phanikumar Turlapati, Devendra Verma et al.In this work, we have investigated mechanical response of hydroxyapatite/polyacrylic composites under dry, wet and simulated body fluid conditions. Hydroxyapatite (HAP) is mineralized under two conditions; one, in presence of polyacrylic acid (in situ HAP), second, in absence of polyacrylic acid (ex situ HAP). Further, in situ and ex situ HAP are mixed with polyacrylic acid to make HAP/PAAc composites. … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 2 · 30 Jun 2006 · 7,395 accessesView PDFCite
Research ArticleOpen accessIn the abstractPolymyositis Initiation Involving Amlodipine BesylateR. M. Golding, L. G.F. Giles, E. M. SokoyaBased on extensive blood pressure data and results from a scientific model of the analysis of the rate processes involved in polymyositis the evidence suggests that the polymyositis in a particular patient was initiated by taking the drug amlodipine besylate (norvasc). The method of our analysis should serve as a foundation in handling other drug related interactions. …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,982 accessesView PDFCite