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Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDFCite
Research ArticleOpen accessIn the abstractHypoglycemic and Antihyperlipidemic Effect of Four Korean Medicinal Plants in Alloxan Induced Diabetic RatsJi Su Kim, Jung Bong Ju, Chang Won Choi, Sei Chang KimTo consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic control. Effect of extracts from … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 9,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpeedup of Particle Transport Problems with a Beowulf ClusterZhongxiang Zhao, G. Ivan MaldonadoThe MCNP code is a general Monte Carlo N-Particle Transport program that is widely used in health physics, medical physics and nuclear engineering for problems involving neutron, photon and electron transport[1]. However, due to the stochastic nature of the algorithms employed to solve the Boltzmann transport equation, MCNP generally exhibits a slow rate of convergence. In fact, engineers and scientists … …American Journal of Applied Sciences, Vol. 3, Issue 8 · 31 Dec 2006 · 6,918 accessesView PDFCite
Research ArticleOpen accessIn the abstractInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,817 accessesView PDFCite
Research ArticleOpen accessIn the abstractCPI-1189 Protects Against Dextran Sulfate Sodium-induced Colitis in MiceBeverley Greenwood-Van Meerveld, Karl R. TylerNitrone-related therapeutics (NRTs) represent a new class of small molecules potentially effective in the treatment of inflammatory bowel disease (IBD) by protecting cells from damage caused by excess inflammation and/or oxidative stress. The goal of this study was to determine the efficacy and potency of CPI-1189, a novel therapeutic agent, in dextran sulfate sodium (DSS)-induced colitis in mice. Mice received … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 6,713 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Growth Hormone Therapy in HIV-infectionDonald P. KotlerThe results of these studies suggested that the growth hormone might play a role in the management of visceral fat accumulation associated with HIV. Analysis of the treatment effect sizes in the published studies show that the effects of various doses of rhGH on trunk fat fit a dose-response characteristic. …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,258 accessesView PDFCite
Research ArticleOpen accessIn the abstractHydroxyapatite-induced Phagocytic Activity by Murine Macrophages in vitroV.K. Gopinath, M. Musa, A.R. Samsudin et al.The aim of the present study was to assess phagocytic activities of murine macrophages (RAW264.7 cell line) to hydroxyapatite (HA) particles. Transmission electron microscope (TEM) was used to assess localization of HA particles in the cells at 7, 15, 30 and 60 min. The HA particles and latex beads, as a control, were also incubated with the cells pretreated with … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,370 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpectrofluorimetric Study of the Charge-transfer Complexation of Certain Fluoroquinolones with 2,3,5,6-tetrafluoro-p-bezoquinoneD. Geffken, H. SalemA highly sensitive spectrofluorimetric method was developed for the first time, for the analysis of ten fluoroquinolones (FQs) antibacterials, namely amifloxacin (AMI), ciprofloxacin (CIP), difloxacin (DIF), enoxacin (ENO), enrofloxacin (ENR), lomefloxacin (LOM), levofloxacin (LEV), norfloxacin (NOR), ofloxacin (OFL) and pefloxacin (PEF) in their pharmaceutical dosage forms or in biological fluids through charge transfer (CT) complex formation with fluoranil (TFQ). The … …American Journal of Applied Sciences, Vol. 3, Issue 8 · 31 Aug 2006 · 6,715 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpirulina protects against cadmium-induced hepatotoxicity in ratsAmr Amin, Alaaeldin A. Hamza, Sayel Daoud, Waleed HamzaCadmium (Cd) is an environmental and industrial cumulative pollutant that most affects many organs specially the liver. The protective effect of Spirulina, filamentous blue green algae, on Cd – induced oxidative stress and hepatotoxicity was evaluated in male rats. Oral administration of water extract of Spirulina for seven days followed by an acute toxic dose of Cd (3.5 mg kg … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 2 · 30 Jun 2006 · 11,533 accessesView PDFCite
Research ArticleOpen accessIn the abstractNano TiO2 Deposited on Crude Mineral and the Photoactivity to the Degradation of ChloroformHaiyan Song, Hongfu Jiang, Xingqing Liu, Guangyao MengSupported TiO2 catalysts have increasingly attracted intention in recent years because of their potential application to photocatalytic degradation of organic pollutants in water and air. In this work, nano TiO2 particles deposited on crude nonmetallic mineral were prepared by a Sol-gel process, the photocatalyst for degradation of chloroform was tested and optimized with respect to TiO2 loading, catalyst dosage and … …American Journal of Environmental Sciences, Vol. 2, Issue 2 · 30 Jun 2006 · 7,368 accessesView PDFCite