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Research ArticleOpen accessIn the abstractZonisamide: The Arizona ExperienceK.J. Oommen, Enriqe LabadieZonisamide (ZNS) is a new antiepileptic drug initially introduced in Europe, Japan and the United States (US) in the late 1980’s and was the first such drug to be clinically tested in the US, since the marketing of valproic acid in 1978. Reports of nephrolithiasis by European and US investigators resulted in the trials being terminated in the US during … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vivo Anti-malarial Tests of Nigella sativa (Black Seed) Different ExtractsH.A.A. Abdulelah, B.A.H. Zainal-AbidinNigella sativa (black seed) seeds have been used as a traditional medicine for the treatment of a variety of sicknesses including parasitic diseases. Intraperitoneal and oral administrations of ethanol, chloroform and aqueous seed extracts (50, 100, 200 and 400 µL kg-1) of N. sativa, were screened in the 4-day suppressive assays for their anti-malarial properties against Plasmodium berghei in mice. … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 8,499 accessesView PDFCite
Research ArticleOpen accessIn the abstractCPI-1189 Protects against TNBS-induced Colitis in a Rodent ModelBeverley Greenwood-Van Meerveld, Karl TylerNitrone-related therapeutics (NRTs) represents a new class of molecules that may be effective in treating inflammatory conditions. The goal of this study was to examine the effect of CPI-1189 in a rat model of inflammatory bowel disease (IBD). Colonic inflammation was induced by an enema of trinitrobenzene sulfonic acid (TNBS). Saline-enema treated rats served as controls. After 3 days colonic … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractNew Bacterial Species Isolated from Malaysian Sea Cucumbers with Optimized Secreted Antibacterial ActivityAbd El-Aziem Farouk, Faizal Abd. Hamid Ghouse, B.H. RidzwanIn this study, several Malaysian sea cucumber species that have traditional medicine value were selected and from them, the native bacterial population was isolated. Optimization of growth was designed and all bacterial secretions were tested for antibacterial properties. 30 bacterial types were isolated and 7 types recorded moderate antibacterial activity against K. pneumoniae, S. marscens, P. aeruginosa and E. feacalis. … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 8,847 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential of Agarose for Biosorption of Cu(II) In Aqueous SystemAnurag Pandey, Debabrata Bera, Anupam Shukla, Lalitagauri RayThe ability of agarose gel as an adsorbent for Cu(II) ions in aqueous solution was studied. The experiments were done as batch processes. Batch kinetics and isotherm studies were carried out under varying experimental conditions of contact time, Cu(II) ion concentration, adsorbent dose, temperature and pH. Adsorption equilibrium of agarose gel was reached within 4 h for agarose gel when … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 2 · 30 Jun 2007 · 6,833 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Anxiolytic and Antidepressant Effects of Alcoholic Extract of Kaempferia parviflora in Aged RatsJintanaporn Wattanathorn, Prasert Pangpookiew, Kittisak Sripanidkulchai et al.To date, the search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has significantly progressed. The present study was performed to evaluate the anxiolytic and antidepressant like activities of the K.parviflora rhizome extract. Aged male Wistar rats were orally administered the alcoholic extract of this plant at various doses ranging from 100, 200 and 300 mg kg-1 BW once … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 9,975 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex FormationH. Salem, L. Fada, W. KhaterA highly sensitive spectrofluorimetric method was developed for the first time, for the analysis of ten fluoroquinolones (FQs) antibacterials, namely amifloxacin (AMI), ciprofloxacin (CIP), difloxacin (DIF), enoxacin (ENO), enrofloxacin (ENR), lomefloxacin (LOM), levofloxacin (LEV), norfloxacin (NOR), ofloxacin (OFL) and pefloxacin (PEF) in their pharmaceutical dosage forms or in biological fluids through charge transfer (CT) complex formation with bromanil (BRO). The … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 7,634 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Vitamin C on the Metabolic Parameters of Experimental Diabetes MellitusMariam Al-Shamsi, Amr Amin, Ernest AdeghateThe role of vitamin C on diabetes mellitus is unknown. The purpose of this study was to examine the effect of oral administration of vitamin C on some of the metabolic parameters of diabetic rats. Diabetes was induced by intraperitoneal injection of STZ (60 mg kgˉ1 body weight at 12 weeks of age). Vitamin C (10, 50, 100 mg kgˉ1 … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 8,072 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffective Coagulation Technology for Treatment of Grease Filter WashwaterAbdel E. Ghaly, A. Snow, B.E. FaberThe treatment of grease filter washwater by chemical coagulation and sedimentation using different dosages of aluminum sulfate was investigated. Pollutant removal efficiency was measured in terms of total solids, pH and optical density. The process was found to be effective at the room temperature and the filter washwater pH (9.5). The optimum aluminum sulfate dosage was 2 g/L. The treatment … …American Journal of Environmental Sciences, Vol. 3, Issue 1 · 31 Mar 2007 · 6,819 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetermination of Diloxanide Furoate and Metronidazole in Binary Mixture Using First Derivative of the Ratio-Spectra and High-Performance Liquid Chromatography-UV MethodsNora H. Al-ShaalanTwo methods are presented for simultaneous determination of diloxanide furoate and metronidazole. The first method depends on first derivative of the ratio-spectra by measurements of the amplitudes at 242.5 and 285.5 nm for diloxanide furoate and 225.5 and 300 nm for metrinidazole. Calibration graphs were established for 2-100 μg mL-1 for diloxanide furoate and 1-50 μg mL-1 for metronidazole. In … …American Journal of Applied Sciences, Vol. 4, Issue 2 · 28 Feb 2007 · 7,719 accessesView PDFCite