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Research ArticleOpen accessIn the abstractPreparation of WO3 Nanoparticles Using Cetyl Trimethyl Ammonium Bromide Supermolecular TemplateNilofar Asim, S. Radiman, M. Ambar bin YarmoProblem statement: WO3 is one of the most interested metal oxides because of its application as catalysts, sensors, electrochromic devices, ceramic, solar cell, pigments and so on. More investigation is needed to find the good and low cost method for preparation of WO3 nanoparticles with uniform morphology and narrow distribution using a surfactant mediated method. Approach: In this study, the … …American Journal of Applied Sciences, Vol. 6, Issue 7 · 31 Jul 2009 · 7,703 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Intravenous Ketamine Administration on Blood Glucose Levels in Conscious RabbitsSuleiman I. Sharif, Hanan A. AbouazraProblem statement: The intravenous general anaesthetic ketamine has been shown to produce changes in blood glucose levels. It is important to study the pharmacological basis of such an effect. Approach: The influence of varying doses of ketamine administered intravenously was studied in conscious rabbits. Serum glucose was determined by blood glucose method using an enzymatic PAP250 kit. Results: Low doses … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 9,950 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro and In vivo Antioxidant Activity of Aphanamixis polystachya BarkAlluri V. Krishnaraju, Chirravuri V. Rao, Tayi V.N. Rao et al.Problem statement: Free radical stress leads to tissue injury and progression of disease conditions such as arthritis, hemorrhagic shock, atherosclerosis, diabetes, hepatic injury, aging and ischemia, reperfusion injury of many tissues, gastritis, tumor promotion, neurodegenerative diseases and carcinogenesis. Safer antioxidants suitable for long term use are needed to prevent or stop the progression of free radical mediated disorders. Approach: Many … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 8,739 accessesView PDFCite
Research ArticleOpen accessIn the abstractCocaine Exposure Results in Formation of Dendritic Varicosity in Rat Primary Hippocampal NeuronsHonghong Yao, Crystal Bethel-Brown, Anil Kumar, Shilpa BuchProblem statement: It has been well documented that drugs of abuse such as cocaine can cause enhanced progression of HIV-Associated Neuropathological Disorders (HAND), the underlying mechanisms mediating these effects remain poorly understood. Approach: In present study, we explored the impact of cocaine exposure (I and 10 μM) on the dendritic beading in rat primary hippocampal neurons. Using the approach of … …American Journal of Infectious Diseases, Vol. 5, Issue 1 · 31 Mar 2009 · 7,895 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Tumor/Immune Interface: Clinical Evidence of Cancer Immunosurveillance, Immunoediting and ImmunosubversionMatthew S. Block, Svetomir N. MarkovicProblem statement: The interactions of a malignant tumor with the patient’s immune system are dynamic, multiple and bi-directional. Approach: This article reviews the clinical evidence of the interaction of cancer with immunity with emphasis on recent developments highlighting some of the mechanisms of tumor-mediated regulation of immunity. Results: Most of the time, the immune response to a malignancy acts to … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 10,100 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,524 accessesView PDFCite
Research ArticleOpen accessIn the abstractCancer Chemotherapy and Immune RegulationJohn Barrett, Katarina Le BlancProblem statement: Chemotherapeutic drugs have been used to treat malignancy for over 50 years, but the potential of cytotoxic agents to suppress immunity and interfere with Immunosurveillance (IS) of cancer has been largely ignored. Assuming that the immune control of the cancer had a priori already failed, the effect was not considered to have a major impact on treatment outcome. … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 40,670 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Phytopthora capsici Activities and Potential Use as Antifungal in Agriculture of Alpinia galanga Swartz, Curcuma longa Linn, Boesenbergia pandurata Schut and Chromolaena odorata: Bioactivities Guided Isolation of Active IngredientsWilart Pompimon, Jinnantina Jomduang, Uma Prawat, Samlee MankhetkornProblem statement: Plant derived fungicides are now being subjects of many research groups. These secondary metabolites have enormous potential to inspire and influence modern agrochemical research. The study aimed to investigate the antifungal activity and their potential use as fungicides in the agriculture of crude extracts and purified compounds derived from plants used in traditional medicines. Approach: Four medicinal plants … …American Journal of Agricultural and Biological Sciences, Vol. 4, Issue 1 · 31 Mar 2009 · 8,709 accessesView PDFCite
Research ArticleOpen accessIn the abstractLow-Birth Weight and Pre-Term Delivery in Relation to Lopinavir/Ritonavir Use in PregnancyJorge Senise, Reisson Cruz, Ricardo Palacios et al.The toxic potential of nevirapine in pregnant women with CD4 count over 250 cells mm-3 and the unsatisfactory efficacy of nelfinavir in patients with baseline Viral Load (VL) over 100,000 copies mL-1 has prompted the use of Lopinavir/ritonavir (LPV/r) in selected situations. This study aims to assess safety of LPV/r in pregnancy. Medical records from pregnant women receiving LPV/r were … …American Journal of Infectious Diseases, Vol. 4, Issue 4 · 31 Dec 2008 · 6,957 accessesView PDFCite
Research ArticleOpen accessIn the abstractAAV-Based Targeting Gene TherapyWenfang Shi, Mingxia Yu, Qijun QianSince the first parvovirus serotype AAV2 was isolated from human and used as a vector for gene therapy application, there have been significant progresses in AAV vector development. AAV vectors have been extensively investigated in gene therapy for a broad application. AAV vectors have been considered as the first choice of vector due to efficient infectivity, stable expression and nonpathogenicity. … …American Journal of Immunology, Vol. 4, Issue 4 · 31 Dec 2008 · 6,964 accessesView PDFCite