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642 articles for “Clinical”
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Research ArticleOpen accessIn the abstractImmunohistochemical Detection of Apoptosis-Related Proteins in Gerbil Hippocampus Transient Cerebral Ischemia: Neuroprotective Effect of PitavastatinToshiki Himeda, Natsumi Hayakawa, Hiroko Tounai et al.Delayed and selective neuronal damage was caused in the CA1 sector of hippocampus following 5 min of transient cerebral ischemia in gerbils. We investigated the immunohistochemical alterations of apoptosis-related proteins such as bcl-2α, bcl-xs/l, bax, cytochrome c, and active caspase 3 and TUNEL staining in the hippocampus at 1 and 5 hr and 1, 2, 5 and 14 days after … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,275 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro Effects of Beet Root Juice on Stimulated and Unstimulated Peripheral Blood Mononuclear CellsChristiana Winkler, Barbara Wirleitner, Katharina Schroecksnadel et al.Intake of fruits and vegetables rich in antioxidants is suggested to reduce the incidence of cancer and coronary heart disease in humans. Exceptional antioxidant activity of beet root extracts has been reported. Likewise in animal models, e.g., extracts of red beetroot Beta vulgaris var. rubra revealed significant tumor inhibitory effects. Red beetroot concentrate is universally permitted as a food ingredient. … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 9,528 accessesView PDFCite
Research ArticleOpen accessIn the abstractPeriodontal Disease as a Risk Factor for Coronary Artery DiseaseGholamali Najafi-Parizi, Ahmad LoriThere are many risk factors for coronary artery disease (CAD) and periodontal disease (PDD) is a controversial risk factor. The aim of this study was to show the association between CAD and PDD. A case-control study was designed. Sixty one patients that CAD was confirm in them by coronary angiography compared with sixty one patients with normal angiography. PDD was … …American Journal of Applied Sciences, Vol. 2, Issue 11 · 30 Nov 2005 · 6,922 accessesView PDFCite
Research ArticleOpen accessIn the abstractSoluble Tumor Necrosis Factor Receptor Type I and Dranulysin as Immunological Markers in Congestive Heart FailureSimone de Lima e Silva Deo, Maria Do Carmo Valente De Crasto, Alda Maria Da-Cruz et al.Previous studies have shown that circulating levels of cytokines are increased in patients with congestive heart failure (CHF), resulting in myocardial depression. In this work, we have determined serum levels of TNF-α and IFN-γ by ELISA, detected sTNFR-I by dot ELISA, as well as TNFα, IL-6, IL-10 and granulysin mRNA in unstimulated peripheral blood mononuclear cells (PBMC) by RT-PCR in … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,776 accessesView PDFCite
Research ArticleOpen accessIn the abstractBotulinum Toxin as a Novel Addition to Anti-Arthritis ArmamentariumHamid Namazi, Zahra MajdOsteoarthritis is the most common joint disease and is among the most frequent health problems for middle aged and older people. There is strong evidence that proinflammatory cytokines contribute to cartilage degradation in osteoarthritis. Interleukin-1 is the prototypical proinflammatory cytokine implicated in the pathogenesis of cartilage matrix degeneration. Results from studies in animal models provide stronger evidence implicating a role … …American Journal of Immunology, Vol. 1, Issue 2 · 30 Jun 2005 · 6,777 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Model for the CD4 Cell Counts in an HIV/AIDS Patient and its Application in Treatment InterventionsRichard O. Simwa, Joseph Y.T. MugishaThe number of CD4 white blood cells has been established as an important clinical marker of disease progression to acquired immunodeficiency syndrome (AIDS) for persons infected with human immunodeficiency virus (HIV). The number of CD4 cells per unit volume is expected to decrease with time since infection by the virus. However on introduction of treatment interventions, the process is expected … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,848 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidences of Hepatitis C Virus Replication in Hepatocytes and Peripheral Blood Monocuclear Cells from Patients Negative for Viral RNA in SerumViviana Falcón, Nelson Acosta-Rivero, Mineko Shibayama et al.In this study, we examined the expression of hepatitis C virus (HCV) components in hepatocytes and peripheral blood mononuclear cells (PBMC) from patients positive for anti-HCV antibodies and negative for serum HCV-RNA. The samples obtained from 25 randomly selected patients (13 of 25 patients showed no histological evidences of chronic hepatitis and had normal serum ALAT and GGTP levels) were … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 7,173 accessesView PDFCite
Research ArticleOpen accessIn the abstractMolecular Genotyping of Mycobacterium tuberculosis Isolates from TurkeyBerrin Gencer, Thomas M. ShinnickTo survey the circulating strains of Mycobacterium tuberculosis in Turkey, all clinical isolates (381 patients) recovered in laboratories in six cities during one-month periods were collected and typed by IS6110-DNA fingerprinting and spoligotyping. Drug susceptibilities were also determined. About 23% of the isolates were resistant to one or more drugs and about 4% were multidrug resistant (i.e., resistant to at … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,735 accessesView PDFCite
Research ArticleOpen accessIn the abstractPhysics Models of Pronuclear Movements in EggsKang Cheng, Changhua ZouBased on published experimental data, Newton's laws, and Coulomb's law, we investigate natural and normal pronuclear movements in wild types of eggs and develop physics models to fit the experimental data quantitatively. The difference between our modeling calculated results and the experimental data is less than 20%. Our models explain why and how pronuclei move in even or in variant … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 1 · 31 Mar 2005 · 6,747 accessesView PDFCite
Research ArticleOpen accessIn the abstractSelective Lymphocyte Activation and Inhibition of In Vitro Tumor Cell Growth by Novel MorphinansRicardo Gomez-Flores, Kimberly R. Vietti, William J. Dunn et al.Opioids can suppress immune functions and increase susceptibility to developing cancer and infectious diseases. Recently, novel opioid compounds have been synthesized that lack immunosuppressive effects. We evaluated the effects of morphinans with substituted pyrimidine (methyl, phenyl, hydroxy, and amino groups) and pyrazole groups on in vitro rat thymic lymphocyte and splenic macrophage functions, and tumor cell growth. We observed that … …American Journal of Immunology, Vol. 2, Issue 1 · 5 Mar 2005 · 7,082 accessesView PDFCite