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62 articles for “therapeutic agent”
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Case ReportOpen accessIn the abstractDisseminated Fusarium Infections in Patients Receiving Posaconazole Prophylaxis: A Report of 2 Patients and Brief Review of the LiteratureJohn Byrne Fournier, Vinod Thomas, Catherine Breen et al.Fusarium is a filamentous fungi that has emerged as a frequent cause of invasive infections in immunocompromised patients. Dermatologists often play a critical role in diagnosing fusariosis, as greater than 70% of patients with disseminated infections have cutaneous involvement, and microbiologic evaluation of skin specimens provides the diagnosis in the majority of cases. Second-generation triazoles are typically the most effective … …American Journal of Infectious Diseases, Vol. 11, Issue 4 · 28 Nov 2015 · 7,372 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Acute Toxicity and Neuropharmacological Activities of PM-52Wipawee Thukhum-Mee, Jintanaporn Wattanathorn, Supaporn MuchimapuraThe neuropsychological disorders are increasing their importance nowadays. Unfortunately, the therapeutic efficacy is still not in satisfaction level. Therefore, the novel agents that are effective, safe, cheap and easy to approach are in required. Therefore, we aimed to determine the neuropharmacological activities of PM52, the novel herbal supplement. We had developed the PM52, a novel product comprising of Cissampelas pariera … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 2 · 27 May 2013 · 7,354 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of New Compound with Antioxidant Potential in the Energy Metabolism of Adults Rats after Pneumococcal MeningitisT. Barichello, Geovana Dagostim Savi, A. P. Panatto et al.Problem statement: In bacterial meningitis, the Streptococcus pneumoniae can modify the cerebro-spinal fluid (CSF) homeostasis and initiation of the host inflammatory response with presence cytokine and leukocyte migration into the subarachnoidal space. Despite the availability of highly effective antibiotics, the disease is often fatal or causes long-term neurological problems in affected patients. Approach: The aim of this study was to … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 15 Jun 2012 · 7,792 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioassay Guided Isolation of Antibacterial Compounds from Andrographis paniculataAbubakar Sule, Qamar Uddin Ahmed, Othman Abd. Samah et al.Problem statement: Chronic disease-causing bacteria of medical importance have developed resistance to antibiotics, hence, necessitating distinct and constant need for safe and efficient therapeutic agents. Plants are considered potent candidate for this aim. A way out of reducing antibiotic resistance and adverse effects on host is the employment of antibiotic resistance inhibitors of plant origin. Approach: About 5 kg pulverized … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 10,027 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of Insulin Receptor Substrate-1 and Some Inflammatory Variables in Hyperinsulinemic Rats Treated with Cinnamon ExtractMohamed H. Mahfouz, Hala M. Ghanem, Mona A. MohamedCinnamon Extract (CE) has shown to be generally safe when ingested and to have many pharmacological properties. Problem statement: Study the effects of daily intake of CE on the modulation of hepatic, cardiac Insulin Receptor Substrate-1 (IRS-1) and their relations to some inflammatory variables in hyperinsulinemic rats. Approach: The influence of CE administered orally was studied in hyperinsulinemic rats. Eighteen … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 7,814 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection against Lipopolysaccharide-induced Death by An Anti-Interleukin-6 Monoclonal AntibodyBailin Liang, Debra Gardner, Don Griswold, Xiao-yu R. SongSepticemia is frequently associated with serious complications and high mortality despite recent advances in treatment with antibacterial agents. Infectious organisms or their soluble products initiate septic shock through a complex cytokine cascade. Lipopolysaccharide (LPS) induced excessive production of inflammatory cytokines is regarded as a model of septic shock. Experiments of LPS-induced excessive cytokine production were conducted in Balb/c mice for … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 6,861 accessesView PDFCite
Research ArticleOpen accessIn the abstractGranulomatous Amoebic Encephalitis: Clinical Diagnosis and ManagementNaveed Ahmed KhanGranulomatous amoebic encephalitis (GAE) is a serious human disease with fatal consequences. With the mortality rate of more than 90%, it is not surprising that the majority of GAE infections are identified at the post-mortem stage. The most distressing aspect is that the high level of mortality is attributed to lack of awareness. Early diagnosis with aggressive treatment can lead … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 7,195 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,031 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDihydroartemisinin Attenuates HBV-Induced Proliferation and Migration in LO2 cells via EMT Pathway ModulationYingde Nong, Caifang Ma, Wei Huang et al.Dihydroartemisinin (DHA), a derivative of artemisinin, possesses well-documented anti-inflammatory properties. This study investigated the inhibitory effects of DHA on hepatitis B virus (HBV)-induced cellular alterations in LO2 cells and elucidated underlying molecular mechanisms. Serum interleukin-6 (IL-6) levels were measured in HBV patients and analyzed for correlations with HBsAg, anti-HBs, and HBeAg. In vitro, LO2 cells were infected with clinical HBV … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 3 · 8 Jan 2026 · 2,079 accessesView PDFCite
Review ArticleOpen accessAll words, across the recordTherapeutic Potential of Medicinal Plants Grown in the Bundelkhand Region of India for Addressing Severe Non-communicable DiseasesNeelam Kashyap, Abha Sachan, Prakash Chandra et al.Herbal Medicines (HMs) have experienced exponential development in the past few years. Consequently, their natural origins and minimal side effects, the popularity of these medications is gradually growing across the globe. Ancient text Rigveda has well documented the remedial application of medicinal herbs for the management of a spectrum of disorders. Phytometabolites derived from plants are rich in bioactive agents, … …American Journal of Agricultural and Biological Sciences, Vol. 20, Issue 1 · 17 Jun 2025 · 6,958 accessesView PDFCite