Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

81 articles for “signaling”
Set a search alert
Also matching:1 special issue
Research ArticleOpen accessIn the abstractK121Q Polymorphism of the ENPP1 Gene is Related to Acute Coronary Syndrome in Ukrainian Patients with Normal but not Enhanced Body Mass IndexInna A. Rozumenko, Victoria Y. Garbusova, Yurij A. Ataman et al.Ectonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) is a class II membrane glycoprotein with two unrelated properties: It can hydrolyze extracellular nucleotides and downregulate insulin receptor signaling. The present study was carried out to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with Acute Coronary Syndrome (ACS) in the representatives of Ukrainian population and to assess if … …OnLine Journal of Biological Sciences, Vol. 14, Issue 4 · 15 Jan 2015 · 7,350 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvidences for the Role of Melatonin as a Protective Additive During Buffalo Semen FreezingMohamed El-Raey, M. R. Badr, Z. M. Rawash, G. M. DarwishTill now, the exact role of melatonin in male infertility hasn’t been fully discovered. Moreover, the intracellular signaling pathways activated by melatonin in buffalo spermatozoa especially on the level of cryopreservation process haven’t been reported. The current study aimed simply to clarify the precise role of this hormone during buffalo semen cryopreservation. Semen samples were obtained randomly from 6 fertile … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 23 Dec 2014 · 8,115 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Interleukin-6 Expression by Curcumin in Rat Vascular Smooth Muscle Explants In VitroYanti, Stephanie, Yuliani et al.In atherosclerotic plaques, infectious agents from microbes may release Lipopolysaccharide (LPS) and heat shock proteins that can stimulate the production of mediators, i.e., pro-inflammatory cytokines, by vascular endothelial cells and Smooth Muscle Cells (SMCs). The elevated level of Interleukin-6 (IL-6) is strongly associated with the development of atherosclerosis. Here, we investigated whether curcumin isolated from the rhizome of Curcuma longa … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 15 Dec 2014 · 6,777 accessesView PDFCite
EditorialOpen accessIn the abstractIMMUNOLOGY IN BRAZIL: CHALLENGES AND OPPORTUNITIES FOR YOUNG SCIENTISTSCarolina PanisThe Brazilian research community has recently emerged as a scientific power. Brazil’s intellectual production has significantly increased in recent years, mostly due to the growing number of young scientists in the country. Approximately 10,000 individuals are conferred the PhD degree in Brazil annually, with corresponding publications of a significant number of research papers. Brazil’s contribution to scientific publications constitutes approximately … …American Journal of Immunology, Vol. 10, Issue 4 · 26 Sep 2014 · 7,160 accessesView PDFCite
Research ArticleOpen accessIn the abstractStructural Consequences of the Polymorphism Q223R in the Human Leptin Receptor: A Molecular Dynamics StudyJonathan P. Carrillo-Vázquez, Brenda Chimal-Vega, Beatriz Zamora-López et al.Leptin Receptor (LEPR) is a component of a signaling pathway related to appetite and energy expenditure. Single Nucleotide Polymorphisms (SNP) of Leptin receptor gene (lepr) have been proposed as possible modulator of adipose tissue and body weight. The main phenomenological consequence reported of these SNPs is the modulation of the LEP-LEPR interaction promoting the weight gain. Particularly, Q223R polymorphism has … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 3 · 23 Sep 2013 · 7,839 accessesView PDFCite
Research ArticleOpen accessIn the abstractMulticast-Supported Fast Handover for Proxy Mobile IPv6V. Berlin Hency, D. SridharanProxy Mobile IPv6 is a network-based mobility management protocol which is attractive as it does not require the participation of mobile nodes in mobility-related signaling. Unlike the host based approaches like Mobile IPv6, in PMIPv6 the Mobility Access Gateway (MAG) is responsible for tracking the movements of Mobile Node (MN) and to initiate the handover process. In this study, a … …Journal of Computer Science, Vol. 9, Issue 3 · 27 Apr 2013 · 6,309 accessesView PDFCite
Research ArticleOpen accessIn the abstractG-2548A Leptin Promoter and Q223R Leptin Receptor Polymorphisms in Obese Mexican SubjectsP. Carrillo-Vazquez Jonathan, Lopez-Alcantar Jeronimo, Chimal-Vega Brenda et al.Leptin interaction with its receptor in the hypothalamus stimulates a specific signaling cascade that results in the synthesis of anorexigenic and orexigenic peptides in order to regulate food intake and energy expenditure. Many polymorphisms in leptin (lep) and leptin receptor (lepr) genes have been associated with body weight. In particular, G-2548A in the lep promoter and Q223R in lepr variants … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 1 · 12 Feb 2013 · 8,645 accessesView PDFCite
Research ArticleOpen accessIn the abstractSclerostin: A Novel Key to Bone and Dental TreatmentGalli Carlo, Lumetti Simone, Manfredi Edoardo et al.Problem statement: Tooth loss can induce dramatical remodeling of alveolar bone because of mechanical loading impairment and strategies to help maintain adequate bone levels for subsequent therapies are sorely needed. Recent discoveries have shown that osteocytes, matrix-embedded cells in bone, respond to mechanical stimulation by modulating the expression of the Sost gene, which encodes for the protein sclerostin. This protein … …Current Research in Dentistry, Vol. 3, Issue 1 · 1 Jan 2013 · 8,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Innate Immunity in Bovine Mastitis: The Role of Pattern-Recognition ReceptorsFernando Nogueira de Souza, Eduardo Milton Ramos Sanchez, Marcos Bryan Heinemann et al.Mastitis is the most costly disease for dairy farmers and industry, which are mainly caused by the entry of bacteria to the teat canal. Shortly after the entry of the invading bacteria, the innate immunity recognizes the invading pathogen through pattern recognition receptors and initiates the inflammatory response necessary to eliminate the invading bacteria. This initial inflammatory response releases cytokines … …American Journal of Immunology, Vol. 8, Issue 4 · 18 Oct 2012 · 10,357 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Cell to Cell Interaction of Breast Cancer Cells Regulates Cancer Invasion Via ADAM15Daichi Ota, Masahiro Ikesue, Yutaka Matsui et al.Increasing evidence suggests that a disintegrin and metalloproteinase 15 (ADAM15) have essential roles in the process of cancer metastasis via degradation of the extracellular matrix and binding to integrins. Among them, ADAM15 possesses an Arg-Gly-Asp (RGD) sequence within its disintegrin domain (d.d., hereafter) and binds to RGD recognizing-integrins such as αvβ3 and α5β1 and also interacts with integrin α9β1 in … …American Journal of Immunology, Vol. 8, Issue 4 · 17 Oct 2012 · 7,690 accessesView PDFCite