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81 results for “renal”
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Case ReportOpen accessIn the abstractEmphysematous Pyelonephritis with Abscesses Masquerading as an Ordinary Urinary Tract InfectionTasnim F. Imran, Frederick Yick, Ahmed H. Qavi et al.Emphysematous Pyelonephritis (EPN) is a rare, gas-forming infection of the renal parenchyma associated with significant morbidity and mortality. We report the case of a 39 year-old woman with uncontrolled diabetes who presented with abdominal pain, fevers and chills for one month. Physical exam was notable for dry oral mucosa and left costovertebral angle tenderness. Labs showed acute kidney injury and … …American Journal of Infectious Diseases, Vol. 11, Issue 4 · 22 Oct 2015 · 7,751 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Combined Fenofibrate and Nicotinamide on Oxidative Stress and Inflammatory Cytokines Involved in Cisplatin-Induced Nephrotoxicity in RatsOmaima M. Abd Allah, Abeer A.I. Sharaf El-Din, Fouad El DebakeyCisplatin (Cis) is an anticancer drug, which is accompanied with major side effects including nephrotoxicity. The current study was performed to assess the possible prophylactic effects of fenofibrate (FEN), Nicotinamide (NAM) and their combination on oxidative stress and inflammatory cytokines associated with cisplatin-induced renal damage. Rats were randomly divided into seven groups (8 each) as follows; control group; FEN group … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 9 Jan 2015 · 7,131 accessesView PDFCite
Research ArticleOpen accessIn the abstractIMPACT OF DEHYDROEPIANDROSTERONE IN PREVENTION OF PARACETAMOL INDUCED NEPHROTOXICITY IN RATSAbbas O. ElkaribParacetamol (PCM) overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms mediating the event. However, Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal gland, has been shown to possess a multi-targeted antioxidant activity which is also effective against lipid peroxidation induced in various animal models and against various human disorders. In this study, the … …Current Research in Medicine, Vol. 5, Issue 1 · 26 Mar 2014 · 7,568 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effects of Propolis on Gamma-Irradiated Nigella sativa Extract Induced Blood and Immune Changes in Wistar RatsOsama Moseilhy Saleh, Mohamed Mohamed Soliman, Ahmed Abdel-Khalik Mansour, Omniya Mahmoud Abdel-HamidThe present study conducted to test the effect of Nigella Sativa (NS, 5 mg kg-1 of body weight), or γ-irradiated Nigella Sativa (GRNS) on the changes of blood component profiles, liver, kidney functions and immune cytokines secretion in male Wistar rats. Moreover, the possible protection by propolis (200 mg kg-1 B. W.) on the changes induced by NS and GRNS … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,468 accessesView PDFCite
Research ArticleOpen accessIn the abstractPerioperative Care of Elderly Surgical PatientsAly SaberAdvancing age is characterized by functional impairment of the many regulatory processes that provide integration between organs and therefore, may lead failure to maintain homeostasis under conditions of physiological stress. There are two main factors helping to identify the high risk for surgery. The first relates to the type of surgery and the second to the scope of cardiopulmonary functional … …Current Research in Medicine, Vol. 4, Issue 1 · 12 Apr 2013 · 8,014 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar RatsAbdullah S. ShatoorProblem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 14,664 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Camel's Milk on Cisplatin-Induced Nephrotoxicity in Swiss Albino MiceMohamed E.M. AfifiProblem statement: Nephrotoxicity is a major complication and a dose limiting factor for cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive oxygen species. Camel's milk has good nutritive value, antigenotoxic and anticytotoxic effects. The aim of the present study was to assess the protective effect of camel's milk against Cisplatin-induced renal oxidative stress in mice. Approach: Forty mal … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,994 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Toxoplasma gondii Antibodies in Haemodialysis PatientsKavous Solhjoo, Abdolreza Sotoodeh Jahromi, Ayeh Parnian-RadProblem statement: In situations of immunodeficiency, Toxoplasma gondii emerges as a life-threatening infection. Toxoplasma gondii is transmitted parenterally, flourish in immunocompromised subjects and, most toxoplasma infections are asymptomatic. Studies have shown that there is a immunodeficiency in renal failure patient such as hemodialysis patients and these patients have a high risk for many infections. There is no evidence about toxoplasmosis … …American Journal of Infectious Diseases, Vol. 6, Issue 1 · 31 Mar 2010 · 9,367 accessesView PDFCite
Research ArticleOpen accessIn the abstractAbnormal Testicular Vascular Patterns amongst Three Trinidadians: (A Case Report)A. Odekunle, E. O. Uche-NwachiDuring our routine dissections to prepare teaching materials for our students we encountered three abnormal patterns of the testicular arteries in three Afro Trinidadian males. In the first case the right and left testicular arteries arose from accessory renal arteries. Their course to the testis remained unchanged. In the second case the left testicular artery arose from the left renal … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 31 Dec 2007 · 7,016 accessesView PDFCite