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161 results for “mice”
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Research ArticleOpen accessEvery word in the titleCPI-1189 Protects Against Dextran Sulfate Sodium-induced Colitis in MiceBeverley Greenwood-Van Meerveld, Karl R. TylerNitrone-related therapeutics (NRTs) represent a new class of small molecules potentially effective in the treatment of inflammatory bowel disease (IBD) by protecting cells from damage caused by excess inflammation and/or oxidative stress. The goal of this study was to determine the efficacy and potency of CPI-1189, a novel therapeutic agent, in dextran sulfate sodium (DSS)-induced colitis in mice. Mice received … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 6,713 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,937 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLarge Scale Production and Characterization of Anti-Human IgG Monoclonal Antibody in Peritoneum of Balb/c MICEB. Baradaran, J. Majidi, Z. M. Hassan, J. AbdolalizadehMonoclonal antibodies are key reagents that are used in biomedical researches, diagnosis of immunodeficiency diseases such as IgG subclasses deficiency and treatment of diseases like infections and cancers. For large scale production of monoclonal antibody, hybridoma cells that produce monoclonal antibody against human IgG were injected into the peritoneum of the Balb/c mice which have previously been primed with 0.5 … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,089 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleγ-Aninobutyric acid (GABA) suppresses antigen-specific immune responses in ovalbumin γ(OVA)-immunized BALB/c miceTohru Sakai, Hiroko Okada, Mitsuo Kise et al.γ-Aminobutruic acid (GABA) is known to be a ubiquitous inhibitory neurotransmitter in the central nervous system. Furthermore, recent studies have shown that GABA modulates cardiovascular and respiratory functions. In this study, we examined the effect of GABA on antigen (Ag)-specific immune responses and elucidated the mechanisms underlying those effects in ovalbumin (OVA)-immunized BALB/c mice. OVA-specific proliferative responses were decreased in … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,501 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntioxidant Activity, Anti-Inflammatory and Analgesic Effects of Caralluma europaea (Eddaghmouss) in MiceAaziz Kebbou, Mehdi Ait Laaradia, Sara Oufquir et al.The aim of the current study is to evaluate the anti-inflammatory, antioxidant and analgesic properties of ethanolic (100 and 200 mg/kg, p.o.) and ethyl acetate extracts (100 and 200 mg/kg, p.o.) of Caralluma europaea. Formalin-induced paw licking test, Acetic Acid induced Writhing Test and Hot-PlateTest were used to assess the analgesic activity. Xylene-induced ear edema test was used to evaluate … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 24 Dec 2019 · 7,598 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Gold Nanoparticles on Serum Lipid Profilein Albino MiceAmmal Esmaeel Ibrahim, Taha Shawi Morad, Dhelal A Shabeeb, Shatha M HasanTriglycerides and lipoproteins are threat features for Cardio Heart Disease. The word “nano” is derived from the Greek word “nanos” which means slight and it is used as introduce for one billionth part (10-9). Conferring to American Society for Testing and Materials. Nanoparticles are those atoms which have two or more than two dimensions and are in the magnitude range … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 31 Oct 2018 · 7,367 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImmune Response, Detection of IgE and PGE2 during Vaginal Candidiasis in MiceRosymar Coutinho Lucas, Rafael Taglialegna, Carolina Nunes França et al.Vulvovaginal candidiasis is an opportunistic infection that affects most women in adult life, but the defense mechanism remains to be elucidated. Animals treated with estradiol were inoculated with Candida albicans having high virulence power. The experimental control consisted of animal groups treated with estradiol and animals without treatment that were inoculated with physiologic serum. The vaginal wall was collected, at … …American Journal of Immunology, Vol. 12, Issue 2 · 14 Jul 2016 · 6,976 accessesView PDFCite
Review ArticleOpen accessIn the keywordsOverview of the Most Popular Currently Used Murine Models of AtherosclerosisAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Alexandra Alexandrovna Melnichenko et al.Atherosclerosis is a widespread and serious problem. Every year it causes a huge number of deaths and morbidity. Many aspects of this disease remain not fully understood, which indicates the need to search for the most representative model of atherosclerosis in animal and cell culture models. Animal models resembling the pathophysiology in humans are needed to study the immunometabolic mechanisms … …OnLine Journal of Biological Sciences, Vol. 24, Issue 2 · 4 Jan 2024 · 4,669 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Effects of Costus Root Aqueous Extract against Schistosomiasis, Liver Damage and Oxidants in Mouse Models of Schistosoma mansoni InfectionAreej Jameel M. AlghabbanSchistosomiasis is one of the major human parasitic diseases in many developing countries that causing chronic ill health in humans. The present work aimed to study the possible curative role of Costus (Saussurea lappa) root extract against Schistosoma mansoni infection induced liver toxicity, cytokines, oxidative stress and DNA damage in mice. 40 adult male micewere divided into four groups (G1, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 15 Apr 2021 · 6,409 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSex Dimorphism in the Fgf21 Gene Expression in Liver and Adipose Tissues is Dependent on the Metabolic ConditionNadezhda Bazhan, Tatiana Jakovleva, Natalia Balyibina et al.Fibroblast growth factor-21 (FGF21) beneficially affects carbohydrate and lipid metabolism. Previously, a sex-specific activation of Fgf21 expression was observed in humans and animals with metabolic diseases. It is unknown whether the sex differences in the Fgf21 expression are manifested in response to the natural physiological situations of fasting and refeeding. The aim of this work was to determine liver, White … …OnLine Journal of Biological Sciences, Vol. 19, Issue 1 · 29 Jan 2019 · 8,153 accessesView PDFCite