54 results for “mRNA Expression”

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Research ArticleOpen accessIn the abstractInflammatory Cytokine Expression Patterns in Rat Skin Exposed to JP-8 Jet FuelRandle M. Gallucci, Bethany M. MickleOne of the main complaints of personnel exposed to JP-8 jet fuel is irritant dermatitis. The purpose of this investigation is to describe the JP-8 induced inflammatory cytokine response in skin over various periods of exposure. JP-8 jet fuel or acetone control (300 μL) was applied to the denuded skin of rats once a day for up to seven days. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,042 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Postgenomic Era: Transcriptomic as the New Paradigm of LifeBruno Giardina, Marcella Renis, Vito Latora, Salvatore MusumeciNow that complete genome sequences are available for a variety of organism, the elucidation of single gene function involved in the metabolism, includes necessarily a better understanding of the cellular responses on all levels of gene products, mRNA, proteins and metabolites. Such knowledge’s growth is essential since the observable properties of living organisms, so called phenotypes, are the results of … …OnLine Journal of Biological Sciences, Vol. 6, Issue 1 · 30 Jun 2006 · 6,822 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInterleukin 10 Induces the Maturation of Putative Tolerogenic Monocyte-derived Dendritic Cells as Revealed by GeneArray AnalysisMarianne A. Jakobsen, Bjarne K. MØller, Klaus Rieneck et al.IL-10 is a multifunctional cytokine with known inhibitory effect on DC maturation. In the present study, we show that the presence of IL-10 during the first 6 days of maturation of Mo-DC has severe effects on the phenotype with IL-10 treated Mo-DC retaining a high expression of factors involved in antigen uptake and having low expression of costimulatory factors and … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,621 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOxidized Low-density Lipoprotein Upregulates GM2 Activator Protein Gene ExpressionHidekatsu Yanai, Hiroshi Yoshida, Hironobu Fujiwara et al.Oxidized low-density lipoprotein (LDL) has been shown to be a powerful regulator of gene expression in monocyte-derived macrophage. To determine the effects of oxidized LDL on macrophage gene expression, macrophages incubated with native or oxidized LDL were analyzed by differential display technique. The differentially expressed cDNA (387 bp) fragment by oxidized LDL showed 100% homology to the part of 3’-untranslated … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,324 accessesView PDF Cite