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Research ArticleOpen accessIn the abstractMetabolic Features of Heart Failure with Different EtiologyOleynikov Dmitrij ArkadievichDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying Doxorubicin-induced Cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. In this study we investigate several metabolic features of doxorubicin-induced cardiomyopathy, … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 1 · 9 Mar 2017 · 7,172 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalytical Method Validation of Vilazodone with Spectrofluorimetric Detection in Rabbit PlasmaIrene Sartini, Marco Salvadori, Beata Łebkowska-Wieruszewska et al.Vilazodone (VLZ) is an antidepressant agent approved in 2011 by Food and Drug Administration (FDA) for the treatment of major depressive syndromes. Its chemical structure derives from trazodone which is used as an off-label drug for dogs and cats in order to induce sedation and reduce anxiety, behavioural and pre-and post-operative stress. VLZ could be a potentially useful compound in … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 1 · 2 Apr 2019 · 7,740 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntimicrobial Resistance in Bacterial Pathogens of Canine OtitisRicardo Antonio Pilegi Sfaciotte, Jéssica Taina Bordin, Vanessa Kelly Capoia Vignoto et al.Otitis is one of the most frequent infections in dogs. This is attributed to the misuse of drugs enabling generation of multi-resistant micro-organisms. The emergence of multiresistant bacterial strains in veterinary medicine is a reality that must be studied and evaluated by the professionals. The objective of this study was to isolate and evaluate the antimicrobial susceptibility of bacterial pathogens … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 3 · 3 Jul 2015 · 7,408 accessesView PDFCite
HypothesisOpen accessIn the abstractCJ-023,423 (Grapiprant) a Potential Novel Active Compound with Antihyperalgetic Properties for Veterinary PatientsMario GiorgiCompanion animals are now living longer and so are more commonly manifesting age- and pain-related disease. Nonsteroidal anti-inflammatory drugs are the most used drug in osteoarthritis and inflammatory pain of various aetiologies. Despite their safety profiles have been amended from the COX-non selective to the COX-2 selective inhibitor class, some adverse effects are still of concern especially in long term … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 14 May 2015 · 8,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary Beta-1,3/1,6-Glucans Reduce Clinical Signs of Canine AtopyA. C. Beynen, D. H.J. Saris, P. M. Paap et al.Problem statement: There was evidence that beta-1,3/1,6-glucans modulate inflammatory activity. In an open, non-controlled trial, purified beta-1,3/1,6-glucans were found to improve the clinical signs of dogs with undefined chronic skin disorders. Given the design of that study, further work was required on the efficacy of beta-1,3/1,6-glucans in the treatment of canine atopy. Approach: The influence of a purified preparation of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 9 Jan 2012 · 9,979 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Dietary Polydextrose on Clinical Signs of Canine OsteoarthritisA. C. Beynen, D. H.J. Saris, L. De Jong et al.Problem statement: Osteoarthritis is an inflammatory joint disease associated with loss of cartilage matrix. There is suggestive evidence that the intake of polydextrose fiber has anti-inflammatory activity. It was reasoned that polydextrose may have a positive influence on canine osteoarthritis. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of STA-LITE® polydextrose in … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 3 · 5 Oct 2011 · 9,052 accessesView PDFCite
Research ArticleOpen accessIn the abstractBeneficial Effect of a Cellulose-Containing Chew Treat on Canine Periodontal Disease in a Double-Blind, Placebo-Controlled TrialA. C. Beynen, F. Van Altena, E. A. VisserProblem statement: There are indications that appropriate chew treats can contribute to the control of canine periodontal disease. It was reasoned that the incorporation of a cellulose fiber network into the treat may improve the efficacy, but for proof experimental data were required. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 3 · 30 Sep 2010 · 8,256 accessesView PDFCite
Research ArticleOpen accessIn the abstractOral Administration of Gelatin Hydrolysate Reduces Clinical Signs of Canine Osteoarthritis in a Double-Blind, Placebo-Controlled TrialA.C. Beynen, H.W. Van Geene, H.V. Grim et al.Problem statement: There are indications that the intake of gelatin hydrolysate has a beneficial impact on the clinical signs of osteoarthritis in dogs. Data from a controlled trial were required to substantiate these indications. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of a preparation of gelatin hydrolysate in the treatment of … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 2 · 30 Jun 2010 · 18,245 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Dietary Beta-1,3/1,6-Glucans on Clinical Signs of Canine Osteoarthritis in a Double-Blind, Placebo-Controlled TrialA.C. Beynen, E. LegersteeProblem statement: There are indications for a beneficial effect of beta-1,3/1,6-glucans on the clinical signs of dogs with osteoarthritis. Data from a controlled trial were necessary to prove or disprove the indications. Approach: A double-blind, placebo-controlled trial with privately owned dogs was carried out to assess the efficacy of a preparation of beta-1,3/1,6-glucans in the treatment of osteoarthritis. With the … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 2 · 30 Jun 2010 · 10,105 accessesView PDFCite
Research ArticleOpen accessIn the abstractLow-cost in vitro Screening Method for Digestibility of Pet ChewsTimothy J. Bowser, Charles I. Abramson, Dwayne BennettFour pet chew treats from four different manufacturers were tested for digestibility using in vitro tests in artificial gastric (stomach) and intestinal juices. In vitro tests were selected to determine the digestibility of dog chews for humane reasons and were conducted under conditions that were designed to simulate the digestive system of dogs. The purpose of the tests was to … …American Journal of Animal and Veterinary Sciences, Vol. 1, Issue 2 · 31 Dec 2006 · 7,552 accessesView PDFCite