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64 results for “T-cell receptor”
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Research ArticleOpen accessIn the abstractExpression of the CD44 Protein in the Heart Valves Affected with Rheumatic Heart DiseaseR. Vijayalakshmi, S. Nayar, K.M. CherianProblem statement: The primary aim was to study the expression of CD44 protein in the heart valves removed surgically for either stenosis or regurgitation and to study the morphology of valves using histochemical staining. Approach: We studied 107 valves which were collected from the International Centre for Cardio Thoracic and Vascular Diseases. Results: Aortic and mitral valves were obtained from … …American Journal of Infectious Diseases, Vol. 6, Issue 4 · 31 Dec 2010 · 7,412 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,579 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Recombinant Human Erythropoietin and Tamoxifen on Growth and Angiogenesis of Mammary Tumor in Sprague-Dawley RatA. K. Sairah, A. Rasedee, O. Sheikh et al.Problem statement: Erythropoietin receptor (EPOR) has been detected in breast cancer cells and speculated to be involved in cancer growth, viability and angiogenesis. This has risen suspicious that EPO administration may enhance the severity of cancer. Approach: This study was undertaken to determine the effects of rHuEPO, Tamoxifen and their combination on the growth and angiogenesis of mammary tumor. Female … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 1 · 31 Mar 2009 · 7,807 accessesView PDFCite
Research ArticleOpen accessIn the abstractToll-Like Receptor (TLR) 2 and TLR4 Gene Expression in Canine HeartA. Linde, F. Blecha, T. MelgarejoToll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic. Of 13 known mammalian paralogues, three TLRs have been identified in the dog. Although cardiac TLR expression has been reported in other species, this study … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 6,924 accessesView PDFCite
Research ArticleOpen accessIn the abstractHeroin-Induces Differential Protein Expression by Normal Human Astrocytes (NHA)Jessica L. Reynolds, Supriya D. Mahajan, Donald Sykes, Madhavan P.N. NairHeroin use is postulated to act as a cofactor in the neuropathogenesis of human immunodeficiency virus (HIV-1) infection. Astrocytes, integral components of the CNS, are reported to be susceptible to HIV-1 infection. Upon activation, astrocytes release a number of immunoregulatory products or modulate the expression of a number of proteins that foster the immunopathogenesis of HIV-1 infection. However, the role … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,267 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation Between Circulating Early Endothelial Progenitors and CD4+CD25+ Regulatory T Cells: A Possible Cross-talk between Immunity and Angiogenesis?Shmuel Schwartzenberg, Adi Mor, Galia Luboshits et al.Regulatory T-cells (Treg) are a recently defined subset of CD4+ cells that can suppress inflammation and induce tolerance. Phenotypically, T-regs are characterized by a high level of expression of the IL-2 receptor alpha chain, CD25. Endothelial progenitor cells (EPCs) can transform into mature endothelial cells and promote vessel formation by inducing postnatal angiogenesis and vasculogenesis. Herein, we tested the hypothesis … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 6,905 accessesView PDFCite
Research ArticleOpen accessIn the abstractRegulation of Gene Expression by β-GlucansMary O. Huff, Carolyn M. Klingeβ-D-glucans are diverse polysaccharides derived from plant cell walls, fungi and bacteria. β-D-glucans are composed of D-glucose monomers linked by (1-3) β-glycosidic bonds with varying amounts of (1-6) or (1-4) linked side chains that bind cell surface receptors ultimately triggering changes in intracellular pathways and gene transcription. β-D-glucans have anti-viral, immunomodulatory and anti-cancer activities. This article reviews the current identity … …American Journal of Immunology, Vol. 13, Issue 1 · 12 Apr 2017 · 7,557 accessesView PDFCite
Research ArticleOpen accessIn the abstractInnate, Adaptive and Intrinsic Immunity in Human Immunodeficiency Virus InfectionSuneth S. Perera, Nitin K. SaksenaThe first line of defence of the innate immune system functions by recognizing highly conserved sets of molecular structures specific to the microbes, termed pathogen-associated molecular patterns, or PAMPs via the germ line-encoded receptors Pattern-Recognition Receptors (PRRs). In addition to the innate immune system, the vertebrates have also evolved a second line of defence termed adaptive immune system, which uses … …American Journal of Infectious Diseases, Vol. 8, Issue 3 · 27 Nov 2012 · 9,727 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatotoxicity Due to Histamine Trifluoro-Methyl Toluidide, Amthamine, R-(-)-α-Methyl Histamine and Clobenpropit (H1R-H4R-Agonists, Respectively) in Rabbit Experimental ModelTrivendra Tripathi, Aijaz Ahmed Khan, Mohammad Shahid et al.Problem statement: Since in vivo studies looking for toxicological impact of histamine receptors-agonists in experimental models are fragmentary, the present study was designed to delineate the histopathological and biochemical changes in livers of rabbits treated with histamine receptors (H1R-H4R)-agonists. Approach: The cohort comprised of six groups (Group I control and Group II-VI treated) containing five rabbits each. Control-group received vehicle … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 8,905 accessesView PDFCite
EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,151 accessesView PDFCite