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Research ArticleOpen accessIn the abstractINVESTIGATION OF STABILITY OF KOREAN GINSENG IN HERBAL DRUG PRODUCTLatifa Bashir Babiker, Elrasheed Ahmed Gadkariem, Riyadh Mohammed Alashban, Haya Ibrahim ALjoharThis study was designed to investigate long term stability of K-Gin capsules, a herbal medication that contains korean ginseng. Stability studies ensuring the maintenance of product quality, safety and efficacy throughout the shelf life are considered as pre-requisite for the acceptance and approval of any pharmaceutical product. Conducting long term stability studies following the guidelines issued by ICH, WHO and … …American Journal of Applied Sciences, Vol. 11, Issue 1 · 18 Dec 2013 · 9,221 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Extraction of Pectic and Polyphenols from Mexican Lime Pomace and BagasseDaniela Sanchez-Aldana, Cristobal Noe Aguilar, Guadalupe Virginia Nevarez-Moorillon, Juan Carlos Contreras EsquivelMexican lime bagasse and pomace are rich in pectin and they also represent an important source of value-added compounds such as polyphenols. Two different options for the combined recovery of pectin and phenolic compounds from Mexican lime bagasse and pomace, two byproducts of industrial lime processing, were developed. Conventional and microwave-assisted extraction methods were used. All pectic extracts presented a … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 4 · 29 Oct 2013 · 7,804 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant and Antimutagenic Activities of Taif Grape (Vitis vinifera) CultivarsAbdelmegid Ibrahim Fahmi, Mohamed Ahmed Nagaty, Ahmed Mohamed El-ShehawiExtract of grape Vitis vinifera has been reported to exhibit antioxidant and antimutagenic activities and the phenolic compounds play a vital role in determining these activities. Therefore; the objective of the present study was to evaluate the antioxidant and anti-mutagenic activities as well as the phenolic composition of different grape cultivar extracts collected from Taif region. The grape cultivars namely; … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 8,010 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Leptospirosis on the Concentrations of Streptomycin in Liver and Kidneys of PigsLabrini V. Athanasiou, Vassilios Papatsiros, George Valiakos et al.Leptospirosis is a re-emerging infectious disease with zoonotic potential. Pigs are reservoir hosts of the pathogen and streptomycin is among the antibiotics proposed to eliminate leptospiral infection. The purpose of this study was to determine streptomycin concentrations and the possible effect of the presence of Leptospira in the liver and kidneys on drug distribution. Six pigs with leptospirosis and six … …American Journal of Animal and Veterinary Sciences, Vol. 8, Issue 1 · 28 Mar 2013 · 7,485 accessesView PDFCite
Research ArticleOpen accessIn the abstractDihydrobiopterin (BH2): Key Determinant in Influencing Arginine Mediated Endothelial Tolerance and DysfunctionSrinidi Mohan, Harsh Patel, Jorge Bolinaga et al.The redox-sensitive tetrahydrobiopterin (BH4) is an essential cofactor that is required by endothelial Nitric Oxide Synthase (eNOS) for L-arginine (ARG) mediated Nitric Oxide (NO) generation. Oxidation of BH4 causes cofactor insufficiency and uncoupling of eNOS, resulting in product switching from NO to O2⋅– production. Here we tested the hypothesis that eNOS uncoupling is not simply a consequence of BH4 insufficiency, … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 2 · 22 Jun 2012 · 8,348 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuantification of Zolpidem in Canine PlasmaMario Giorgi, Alessandra Gavazza, Hyoin YunProblem statement: Zolpidem is a non-benzodiazepine hypnotic agent currently used in human medicine. In contrast to benzodiazepines, zolpidem preferentially binds with the GABAA complex ϖ1 receptors while poorly interacting with the other ϖ receptor complexes. Recent studies have suggested that ZP may be used to initiate sedation and diminish severe anxiety responses in dogs. The aim of the present study … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 19 Mar 2012 · 7,908 accessesView PDFCite
Research ArticleOpen accessIn the abstractBioautography Guided Identification of Anticandidal Compounds from A. terreus st. 1B. K. Nagaraja, R. Sripathy, C. N. Ramchand, M. SundararamanProblem statement: Saprophytic and soil inhabiting microorganisms are prolific producers of secondary metabolites with wide range of structural and functional diversity. The objective of the current study was to screen and evaluate the anti-candidal properties of soil inhabiting fungi. Approach: Preliminary dual culture assay and bioautography was used to screen the fungi with potential anti-fungal activity and direct detection of … …American Journal of Infectious Diseases, Vol. 7, Issue 4 · 1 Dec 2011 · 7,629 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Induction of Lycopene in Germinating Cottonseed with 2-(4-Methylphenoxy) Triethylamine (MPTA)Lorraine S. Puckhaber, Jinggao LiuAbstract: Problem Statement: Increasing carotenoids content in foods was currently of great interest. The present paper reports strong stimulatory effect of MPTA on the carotenogenesis in cotton, which was used as a model. Approach: Cotton seedlings were treated with MPTA vs. water and germinated in the dark. The levels of carotenoids were determined by HPLC and the expression levels of … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 1 · 26 Jul 2011 · 7,950 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelation between Macroscopic Binding Constant and the Anticancer Efficacy of the Bovine Serum Albumin-Quercetin Complex against Drug-Sensitive and Drug-Resistant CellsWinit Choiprasert, Chatchanok Loetchutinat, Nathupakorn Dechsupa, Samlee MankhetkornProblem statement: We have previously analyzed the interaction of BSA with flavonoids by using FRET. In this study, the role of BSA on increasing in solubility and on carrying the quercetin derivatives thus enhanced their anticancer efficacy against drug-sensitive and drug-resistant cells were conducted. Approach: The macroscopic (KD) and microscopic (kd) binding constant of the complexation and the cellular partition … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 May 2011 · 8,292 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Plant Growth Regulators on Callus, Cell Suspension and Cell Line Selection for Flavonoid Production from Pegaga (centella asiatica L. urban)Suat Hian Tan, Radzali Musa, Arbakariya Ariff, Mahmood MaziahProblem statement: Considering pegaga medicinal properties and over-exploitation, the requirement for a tissue culture technique as an alternative production system was crucial. Approach: Investigation of cell suspension culture response to different plant growth regulators (PRGs) for flavonoid production from elite cell line was carried out. Callus cultures were initiated from the leaf explants of Centella asiatica on Murashige and Skoog … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 4 · 31 Dec 2010 · 11,254 accessesView PDFCite