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140 articles for “Drug Problem”
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Research ArticleOpen accessIn the abstractCase Report of Severe Injection Site Reaction Associated with Intramuscular NaltrexoneJill A. Covyeou, Katharine E. Atto, Chadwick W. Howard, Jessica R. SchultzProblem statement: To report a case of severe injection site reaction at the site of an IM naltrexone injection in a 30 year old female. Approach: A 30 year old female, being treated with naltrexone extended-release injectable suspension for alcohol dependence, presented with a mass on her left upper gluteal area at the site of injection. The injectable naltrexone was … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 7,663 accessesView PDFCite
Research ArticleOpen accessIn the abstractAn Enhancement of Bayesian Inference Network for Ligand-Based Virtual Screening using Features SelectionAli Ahmed, Ammar Abdo, Naomie SalimProblem statement: Similarity based Virtual Screening (VS) deals with a large amount of data containing irrelevant and/or redundant fragments or features. Recent use of Bayesian network as an alternative for existing tools for similarity based VS has received noticeable attention of the researchers in the field of chemoinformatics. Approach: To this end, different models of Bayesian network have been developed. … …American Journal of Applied Sciences, Vol. 8, Issue 4 · 18 Apr 2011 · 7,724 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,193 accessesView PDFCite
Research ArticleOpen accessIn the abstractFrequency of P/S(XX)P Duplication and FRFE, Absence of LYP in P6Gag of Indian Human Immunodeficiency Virus-1 Subtype C IsolatesKrutika Wadekar, Sudhanshu Pandey, Preeti Jain et al.Problem statement: The presence of a p6 domain at the C-terminus of the Gag polyprotein is a characteristic feature of HIV-1 and other primate lentiviruses. The p6Gag protein is considered as a major phosphoprotein in mature HIV-1 virions and is involved in the viral assembly and budding process. Sequence variation in the p6gag region in HIV-1 has been associated with … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,531 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Prospective Evaluation of Antihypertensive Medications Safety and Efficacy in United Arab Emirates Private HospitalsMuaed Jamal Alomar, Claire Caroline StrauchProblem statement: Hypertension is one of the most important risk factors for heart and cardiovascular diseases in the United Arab Emirates (UAE). Evaluation of the safety and efficacy of antihypertensive medications in UAE private hospitals is important. The importance arises because of the high prevalence of hypertension in this multicultural region. This study evaluated the use of antihypertensive medications among … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,316 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence and Antibiotics Susceptibility of Uropathogens in Patients from a Rural Environment, TamilnaduMaripandi Arjunan, Ali A. Al-Salamah, M. AmuthanProblem statement: Urinary Tract Infections (UTIs) in human, rural environment cause significant morbidity due to insanitary condition, lack of knowledge of personal hygiene, lack of patient’s compliance and economic burden. In our study, the bacterial etiologies and the resistance patterns found in human with serious UTIs and selecting optimal antimicrobial therapy. Approach: A total of 105 patients first morning mid … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 8,712 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Emergence of Drug Resistance in HIV Associated Bacterial Urinary Tract InfectionsS. D. Deokar, M. G. BodhankarProblem statement: This study was designed to document the prevalence of HIV associated urinary tract infections in Barshi Tahsil. Such studies had not been researched out before in this region. Approach: The study included samples from 123 HIV reactive and 40 HIV non-reactive patients. In both, mid stream samples were collected and processed to examine for bacterial opportunistic pathogens. The … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 8,472 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Enicostemma littorale Blume on Rat Model of Diabetic NeuropathyNiraj Mukundray Bhatt, Suparna Barua, Sarita GuptaProblem statement: Poor glycemic control and oxidative stress is implicated as a common pathway in the development of diabetic neuropathy. Approach: In the present study, we investigated the protective effects of Enicostemma littorale Blume (EL) (2.5 g kg-1), a hypoglycemic and antioxidant herbal medicine in alloxan-induced diabetic neuropathy in male Charles foster rats. Results: Tail flick latency in hot immersion … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,841 accessesView PDFCite
Literature ReviewOpen accessIn the abstractMitochondrial Dysfunction Model in the Pathogenesis of Inflammatory Response Development in ObesityAlexander Blagov, Varvara Orekhova et al.Obesity is one of the growing problems of modern society. Although currently used methods of treating obesity, including diet, exercise, and drug therapy, have shown their applicability to more effectively combat obesity, an understanding of the pathogenesis of this disease is required. One of the insufficiently studied factors in the pathogenesis of obesity is the development of mitochondrial dysfunction understanding … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 19 Nov 2023 · 4,937 accessesView PDFCite
Research ArticleOpen accessIn the abstractCortisol Response Mediates HIV-1-Related Cognitive Deficits Among Injecting Drug AbusersRaymond L. Ownby, Drenna Waldrop-Valverde, Adarsh M. Kumar et al.The cortisol response is an important measure of the endocrine activity to environmental challenges and has been related to cognitive function and mood. Previous studies have shown that the cortisol response to stress is dysregulated in persons with HIV-1 infection. Since cortisol is neurotoxic and its levels have been related to cognitive dysfunction in various disorders, it is possible that … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 6,762 accessesView PDFCite