54 articles for “Drug Design”

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Research ArticleOpen accessIn the abstractIn silico Modeling of α1A-Adrenoceptor: Interaction of its Normal and Mutated Active Sites with Noradrenaline as well as its Agonist and AntagonistRamchandran Vijayan, Naidu Subbarao, Birendra Nath MallickNoradrenaline, like most other neurotransmitters, acts through various adrenoceptor subtypes. The structure and active site of adrenoceptors for the binding of noradrenaline were unknown, however, such information are crucial for understanding the molecular mechanism of action of neurotransmitters, including noradrenaline, in health and disease as well as for drug designing. In this in silico study, we modeled the α1A-adrenoceptor; a … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,144 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordFuture Medicine Services RoboticsRelly Victoria V. Petrescu, Raffaella Aversa, Antonio Apicella, Florian Ion T. PetrescuIt is an entry technique in use recently, albeit in selected centers and represents a further step in the field of minimally invasive surgery. Basically it has the same indications but, at present, is reserved for selected patients. Compared to traditional video-assisted surgery presents some important differences. The surgeon is physically distant from the operative field and sits at a … …American Journal of Engineering and Applied Sciences, Vol. 9, Issue 4 · 26 Nov 2016 · 8,893 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,110 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordVariability in Antihypertensive Drug Therapy and Compliance: Results from a Random Survey in the United Arab EmiratesSyed Azhar Syed Sulaiman, Muaed Jamal Alomar, Claire Caroline StrauchProblem statement: Hypertension is one of the most common diseases known as the ‘silent killer’ because it shows no clinical signs and symptoms. The high prevalence of hypertension in the United Arab Emirates stresses the importance to initiate a nation-wide effort to prevent and control high blood pressure in the population, especially since the prevalence rates are indicative of one … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 7,232 accessesView PDF Cite