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Research ArticleOpen accessEvery word in the titleKinetic Optimization of Folic Acid Polymer Conjugates for Drug TargetingJacob M. Ngoy, Sunny E. Iyuke, Clarence S. Yah, Wilhelm E. NeuseProblem statement: Folic Acid (FA) is an essential, bioavailable water soluble B-complex vitamin that helps in the replication of normal cells. It is obtained from natural sources and it deficiency can leads to oncogenic cells development. Within this frame work in mind, we designed and synthesized a new bioconjugate carrier that can enhance the effectiveness of FA. Approach: The polymeric … …American Journal of Applied Sciences, Vol. 8, Issue 6 · 13 Jun 2011 · 7,110 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDrug Interaction between Salinomycin and Exogenous Adrenaline in DogsHamid Rajaian, Javad Sajedianfard, Saeed Nazifi, Ali Moosavi KianProblem statement: Salinomycin is a member of ionophore compounds that may be used in ruminants and pigs as growth promoter or to prevent coccidiosis. There are some reports with respect to the in vitro and in vivo sympathomimetic cardiovascular effects of salinomycin. Available reports indicate that adrenergic impact of the ionophore is brought about by an increase in the secretion … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 2 · 30 Jun 2009 · 7,544 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDelftia Acidovorans Bacteremia in an Intravenous Drug AbuserRocco J. Perla, Eric L. KnutsonDelftia acidovorans (Comamonas acidovorans) is an aerobic, non-fastidious, non-fermentative gram-negative bacillus classified in the Pseudomonas rRNA homology group III that is generally regarded as an environmental organism found in soil and water and as a non-pathogen. We report the first case of systemic D. acidovorans infection in a patient without a long-term immunosuppressive condition where D. acidovorans has been recovered … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 7,311 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleOptic Neuropathy: Characteristic Pathology for Identifying Drugs with Potential to Cause Mitochondrial ToxicityConnor Dyer, Katlyn Droke, Ugne Zekonyte, Mariana RoscaDeleterious effects on mitochondria are known to be frequently caused by prescription drugs, however, there is no standard and specific testing by pharmaceutical companies on these effects on mitochondria during drug development. The objective of this study is to determine if cases of optic neuropathy are related to drug-induced mitochondrial toxicity in a way that could be used to predict … …American Journal of Pharmacology and Toxicology, Vol. 18, Issue 1 · 19 Jan 2024 · 8,567 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,031 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRacialization of Drug Use and Gang Involvement: Racial Crime Stereotype of Minorities, Fear of Crime and the Impact of SexVeronica M. Ahadzie, Robert L. PeraltaThis study examines how racialized crime and drug stereotypes of African Americans and Hispanics affect the fear of crime. Based on racial threat theory, which argues that members of the majority racial group perceive the increasing minority group population as threatening, and labeling theory, which argues that labeling someone as "deviant" reinforces that behavior and affects how they are treated, … …Journal of Social Sciences, Vol. 20, Issue 1 · 2 Jan 2025 · 5,599 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnalysis of the Utility of MPT64, Drug Susceptibility Testing and Tuberculosis/Nontuberculous Mycobacteria Reverse Transcription Polymerase Chain Reaction for Tuberculosis Diagnosis and Efficiency Compared with Traditional CultureHo Keun Choi, Ga Yeon Kim, Tae Soung Kim, Jae Kyung KimDefining the molecular mechanisms underlying the dormant state of Mycobacterium tuberculosis (MTB) is essential for developing more effective treatments for tuberculosis (TB) infection. We investigated the positivity and resistance rates of TB tests on 6,174 samples referred to a single hospital. Of these, 342 cases (5.5%) were confirmed as positive by acid-fast bacilli staining, 243 cases (71.1%) were detected as … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 4 · 5 Dec 2024 · 4,211 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGenetic Diversity and Drug Resistance of Mycobacterium tuberculosis Complex Isolates and Nontuberculous Mycobacteria Identification from Presumptive Tuberculosis Cases in Oaxaca, MexicoNakamura-Lopez Yuko, Valencia-Carmona Oscar Daniel, Martinez-Cruz Perla Monica et al.Tuberculosis (TB) is a re-emerging health problem worldwide. In Mexico, information about genetic diversity and drug resistance of Mycobacterium Tuberculosis complex (MTBc) is limited. Samples from 463 Presumptive TB cases were tested for TB by smear, culture and PCR, from which 19.2% were identify as MTBc and 16% as nontuberculous mycobacteria. MTBc isolates were characterized by Large Sequence Polymorphisms (LSPs), … …American Journal of Infectious Diseases, Vol. 16, Issue 1 · 9 Feb 2020 · 7,164 accessesView PDFCite