53 results for “Clinical Trials”

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Research ArticleOpen accessIn the abstractComparisons of Test Statistics for Noninferiority Test for the Difference between Two Independent Binominal ProportionsYouhei Kawasaki, Fanghong Zhang, Etsuo MiyaokaProblem statement: Noninferiority tests are frequently used in clinical trials to demonstrate that the response for study drugs is not much worse than the response for reference drugs. Several test statistics exist. However, a detailed comparison of those test statistics is not researched. Moreover, a little complex calculation might be necessary in some of those test statistics. Approach: In this … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 14,098 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPrevalence of Oncogenic HPV Types in Sardinia (Italy): Implications for the Impact of Prophylactic Anti-HPV VaccinesStefania Montisci, Sabrina Pitzalis, Marianna Greco et al.Infection with high-risk HPV genotypes is considered an essential step in cervical carcinogenesis. Recently, prophylactic anti-HPV vaccines have shown to provide effective protection in clinical trials. However, protection appears to be type-restricted, thus, its real extent will depend on HPV types prevalence in the target population. Here we report HPV prevalence in 555 Italian women with various stages of HPV-related … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,036 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSensitivities of Uterine Adenocarcinoma, Mixed Mullerian Tumor (MMT) and Sarcoma Cell Lines to Chemotherapeutic Agents and a Flex-Het DrugJohnny Hyde, Doris M. BenbrookThe administration and combination of a variety of chemotherapeutic agents for treatment of advanced or recurrent uterine cancer of different histologies is under current debate. Mixed Mullerian Tumors (MMTs), which contain both adenocarcinoma and sarcoma components, are the most rate histologic type and it is therefore difficult to conduct clinical trials to determine if they should be treated like endometrial … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,460 accessesView PDF Cite