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52 articles for “CD4+”
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Research ArticleOpen accessIn the abstractMelanoma-Associated Suppression of the Dendritic Cell Lines DC2.4 and JawsiiKristian Michael Hargadon, Yonathan Tarekegne Ararso, Osric Anthony Forrest, Chad Mason HarteDendritic cells function as potent regulators of both innate and adaptive immunity to tumors and the regulatory activities of these cells are tightly linked to their maturation and activation status. Despite the critical role played by dendritic cells in the induction of anti-tumor immune responses, the number of dendritic cells that can be isolated from experimental animals is limiting and … …American Journal of Immunology, Vol. 8, Issue 4 · 3 Nov 2012 · 9,559 accessesView PDFCite
Research ArticleOpen accessIn the abstractRal-Binding Protein is Required for the Maturation and Function of Dendritic CellsJozef Borvak, Mukesh Sahu, Varun Joy et al.Problem statement: Dendritic Cells (DCs) integrate responses of innate and adaptive immune system via transmitting pro-inflammatory and regulatory signals to naïve cells within draining lymph nodes. DCs have high capacity for endocytosis, both Clathrin-Dependent (CDE) and Caveolin-Dependent (CvDE). Approach: We have recently shown that ATP-hydrolysis by the multifunctional transporter protein RLIP76 is the primary determinant of the rate of CDE. … …American Journal of Immunology, Vol. 6, Issue 3 · 13 Sep 2010 · 8,095 accessesView PDFCite