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Research ArticleOpen accessIn the abstractDetermination of Metoprolol and Felodipine in Binary Mixture Using Chemometric-Assisted Spectrophotometric and High-Performance Liquid Chromatographic-UV MethodsHesham Salem, Ola M. AbdallahFour methods were developed for simultaneous determination of metoprolol and felodipine without previous separation. In the first method both drugs were determined using first derivative UV spectrophotometry, with zero crossing measurement at 222 and 235 nm for metoprolol and felodipine, respectively. The second method depends on first derivative of the ratios spectra by measurements of the amplitudes at 250.1 nm … …American Journal of Applied Sciences, Vol. 4, Issue 9 · 30 Sep 2007 · 8,028 accessesView PDFCite
Research ArticleOpen accessIn the abstractAtomic Absorption Spectrometric Determination of Certain Fluoroquinolones in Pharmaceutical Dosage Forms and in Biological FluidsH. Salem, W. Khater, L. FadaSimple, accurate, sensitive and selective methods are described for the quantitative determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin, enrofloxacin, lomefloxacin hydrochloride, levofloxacin, norfloxacin, ofloxacin and pefloxacin mesylate). The methods are based on precipitation of the ion associates formed from the reaction of the cited drugs with silver nitrate, copper acetate and ferric chloride. The formation and solubility … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,424 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Novel Heat Shock Transcription Factor Family in Entamoeba histolyticaConsuelo G. García, Ma. De la Luz Macias Argüelles, D. Guillermo P Ishiwara et al.The HSTF is a master molecule involved in the transcriptional control of several genes during different types of stress. This transcription factor is a very conserved protein identified in different organisms from bacterial to human. Entamoeba histolytica is the protozoan responsible for the human amoebiasis. This parasite is exposed to different kind of stress as changes in the pH, temperature, … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,186 accessesView PDFCite
Research ArticleOpen accessIn the abstractEmetine produce Entamoeba histolytica Death by Inducing a Programmed Cell DeathJ.D. Villalba-Magdaleno, R. Rojas, C. Gómez et al.Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment and the molecular targets of these drugs have been identified, the biochemical and physiological mechanisms that produce trophozoite death are little known. The present study dates the in vitro induction of programmed cell death (PCD) in E. … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,214 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Phenotypically Suppressed Cancer Cell As a Therapeutic TargetKimberly D. Kyker, Jessica E. Thorpe, Satyendra S. Shenoy et al.Bladder cancer recurs in up to 70% of patients judged to be tumor-free after treatment. Like other cancers, delayed appearance of metastases is common. These findings suggest the malignant phenotype can be suppressed, to emerge later. Following up on previous research in our laboratory showing that normal extracellular matrix can suppress the malignant phenotype of bladder cancers, we here demonstrate … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,474 accessesView PDFCite
Research ArticleOpen accessIn the abstractPathophysiology of Adipocyte Defects and Dyslipidemia in HIV Lipodystrophy: New Evidence from Metabolic and Molecular StudiesAshok Balasubramanyam, Rajagopal V. Sekhar, Farook Jahoor et al.Despite a burgeoning mass of descriptive information regarding the epidemiology, clinical features, body composition changes, hormonal alterations and dyslipidemic patterns in patients with HIV lipodystrophy syndrome (HLS), the specific biochemical pathways that are dysregulated in the condition and the molecular mechanisms that lead to their dysfunction, remain relatively unexplored. In this paper, we review studies that detail the metabolic basis … …American Journal of Infectious Diseases, Vol. 2, Issue 3 · 30 Sep 2006 · 6,611 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,862 accessesView PDFCite
Research ArticleOpen accessIn the abstractSurvival in the Current Healthcare Environment How Close Are We to Socialized Medicine?Eldo E. FrezzaIn the 1980's, some hospitals established internal agencies to regulate cash flow and capital expense. State agencies promoted the evolution of healthcare facilities into more business-like organizations. Attention to the following matters will reduce hospital costs: 1) prevent or reduce nosocomial infections; 2) treat diseases at a stage amenable to outpatient therapy; 3) obtain complete information about the policies of … …Journal of Social Sciences, Vol. 1, Issue 4 · 31 Dec 2005 · 6,693 accessesView PDFCite
Research ArticleOpen accessIn the abstractPeriodicity of the HIV/AIDS Epidemic in a Mathematical Model that Incorporates ComplacencyFlugentius Baryarama, Livingstone S. Luboobi, Joseph Y.T. MugishaAn HIV/AIDS model incorporating complacency for the adult population is formulated. Complacency is assumed a function of the number of AIDS cases in a community with an inverse relation. A method to find the equilibrium state of the model is given by proving a stated theorem. An example to illustrate the application of the theorem is also given. Model analysis … …American Journal of Infectious Diseases, Vol. 1, Issue 1 · 31 Mar 2005 · 6,634 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpectrofluorimetric, Atomic Absorption Spectrometric and Spectrophotometric Determination of Some FluoroquinolonesHesham SalemSimple, accurate, sensitive and selective spectrofluorimetric, atomic absorption spectrometric and spectrophotometric methods are described for the quantitative determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin, enrofloxacin, lomefloxacin hydrochloride, levofloxacin, norfloxacin, ofloxacin and pefloxacin mesylate). The first method was a spectrofluorimetric method in which samples of the studied drugs in 0.1 N H2SO4 showed native fluorescence at 450 nm … …American Journal of Applied Sciences, Vol. 2, Issue 3 · 31 Mar 2005 · 7,320 accessesView PDFCite