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Research ArticleOpen accessIn the abstractEnvironmental Factors and Limbic Vulnerability in Childhood AutismRichard LatheThe rise in prevalence of autism spectrum disorders (ASD) is suggestive of a new etiology. Diagnostic substitution alone is unlikely to account for the increase, while genetic association with detoxification gene alleles points to an environmental contribution. Subtle structural anomalies in the ASD brain are widespread but limbic damage seems important for the development of behaviors diagnostic of ASD. The … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 7,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractSurveying on Wheat Farmers' Access and Confidence to Information and Communication Channels (ICCs) about Controlling Eurygaster integriceps in Hamedan Province-IranHeshmatollah Saadi, Karim Naderi Mahdei, Reza MovahediToday, Generation new and various information and knowledge sources need new information and communication channels. The better selection of information and communication channels (ICCs), the more effectiveness of extension programs in agriculture. Surveying on wheat farmers’ access to sources of information and communication channels as ICCs about controlling Eurygaster integriceps Puton in Hamedan province of Iran is primary purpose in … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 2 · 30 Jun 2008 · 8,058 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Factors Influencing Rural People's Participation in National Action Plan for Sustainable Management of Land and Water Resources in Hable-Rud Basin, IranElham Faham, Seyed Mahmood Hosseini, Amir Keivan DarvishThe purpose of this study was to analyze factors influencing rural people's participation in National Action Plan for Sustainable Management of Land and Water Resources (NAP-SMLWR) in Hable-Rud Basin. This study is a case study of Arou village in northern Hable-Rud basin. The statistical population includes head of households who dwelling in Arou village and participate in this project. Available … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 2 · 30 Jun 2008 · 8,248 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormesis: Principles and Applications for Pharmacology and ToxicologyEdward J. CalabreseThe present assessment places hormetic dose responses within an historical context, documenting its origin, rejection by the biomedical community during the early decades of the 20th due to its close association with homeopathy and its revitalization during the later decades of the past century as the biomedical and toxicological communities became very interested in low dose effects of drugs and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,210 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic Interventions in AgingSuresh I.S. RattanSingle or multiple exposure to low doses of potentially harmful agents can have a variety of anti-aging and longevity-extending hormetic effects. These hormetic stressors include irradiation, physical activity, food limitation, heat, hypergravity, dietary components and reactive oxygen species. Molecular mechanisms facilitating the hormetic effects are being elucidated and comprise a cascade of stress response and maintenance and repair pathways. Although … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,831 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Cholesterol Esterification Influences Cytokine Exspression in Lypopolisaccharide-activated P388D1 MacrophagesRosa Rita Bonatesta, Francesca Sanna, Sabrina Uda et al.Several in vivo and in vitro studies have demonstrated the involvement of infectious agents in the development of atherosclerosis. However, the mechanisms by which micro-organisms induce and/or aggravate atherosclerosis, are so far unclear. Accumulation of cholesterol esters and lipid laden cell formation are hallmark of the atherogenesis, however, the possible relationship between cholesterol esterification and the signal-transducing component of LPS … …American Journal of Infectious Diseases, Vol. 3, Issue 3 · 30 Sep 2007 · 7,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractEmetine produce Entamoeba histolytica Death by Inducing a Programmed Cell DeathJ.D. Villalba-Magdaleno, R. Rojas, C. Gómez et al.Amoebiasis is a major public health problem in tropical and subtropical countries. Although a number of antiamoebic agents are used for its treatment and the molecular targets of these drugs have been identified, the biochemical and physiological mechanisms that produce trophozoite death are little known. The present study dates the in vitro induction of programmed cell death (PCD) in E. … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,211 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Proteolytic System of Candida dubliniensisLoaiza-Loeza Salomé, Parra-Ortega Berenice, Bautista-Muñoz Consuelo et al.Proteases of Candida dubliniensis have been scarcely studied, these enzymes may play an important role in nitrogen metabolism, post-translational processing, nutritional stress, dimorphism, virulence, etc. In this work, we report the presence of five different intracellular proteases and one extracellular proteolytic activity. The intracellular proteases are: aminopeptidase ycdAPE, carboxypeptidase ycdCP, dipeptidyl aminopeptidase ycdDAP, proteinases ycdPrA and ycdPrB, and extracellular protease … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 6,953 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection against Lipopolysaccharide-induced Death by An Anti-Interleukin-6 Monoclonal AntibodyBailin Liang, Debra Gardner, Don Griswold, Xiao-yu R. SongSepticemia is frequently associated with serious complications and high mortality despite recent advances in treatment with antibacterial agents. Infectious organisms or their soluble products initiate septic shock through a complex cytokine cascade. Lipopolysaccharide (LPS) induced excessive production of inflammatory cytokines is regarded as a model of septic shock. Experiments of LPS-induced excessive cytokine production were conducted in Balb/c mice for … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 6,856 accessesView PDFCite