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Research ArticleOpen accessIn the abstractUsing Bioequivalence Approach to Assess Toxicity Effect of Herbal Products, TyrelTM and RumbionTMChunhao Tu, Woon Yuen KohProblem statement: Herbal products have been widely used in veterinary healthcare. Recently, an experiment was conducted in the Natural Animal Facility Pvt. Ltd., Bangalore, India on ten Albino Wistar female mice to assess the acute oral toxicity of two herbal products, TyrelTM and RumbionTM. However, the researchers did not evaluate the toxicity effect of the two products in terms of … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 7,826 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecreased Intensity of Japanese Encephalitis Virus Infection in Chick Chorioallantoic Membrane Under Influence of Ultradiluted Belladonna ExtractBhaswati Bandyopadhyay, Satadal Das, Milan Sengupta et al.Problem statement: No specific antiviral therapy is currently available despite an emergence and resurgence of Japanese encephalitis in South-East Asian Countries. There are only few recent studies, which were aimed to treat Japanese encephalitis with newer drugs. There is thus a real need for study on antiviral agents that can reduce the toll of death and neurological sequelae resulting from … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 9,431 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparisons of Test Statistics for Noninferiority Test for the Difference between Two Independent Binominal ProportionsYouhei Kawasaki, Fanghong Zhang, Etsuo MiyaokaProblem statement: Noninferiority tests are frequently used in clinical trials to demonstrate that the response for study drugs is not much worse than the response for reference drugs. Several test statistics exist. However, a detailed comparison of those test statistics is not researched. Moreover, a little complex calculation might be necessary in some of those test statistics. Approach: In this … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 14,104 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Inhibition of Human Pathogens: Trichophyton rubrum and Trichoderma harzianum by a Natural ProductRand R. Hafidh, A.S. Abdulamir, Law Se Vern, Fatimah Abu BakarProblem statement: A number of studies have recently conducted to identify novel and potent antifungal components from natural products. One of the reasons is to overcome the antifungal resistant developed against most of commercially available drugs. Studies confirmed that mung beans have increased phenolic compounds and enhanced defenses during germination. Approach: We hypothesized that antifungal activities might be found in … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 9,365 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntilithiatic Influence of Spirulina on Ethylene Glycol-Induced Nephrolithiasis in Male RatsAtef M. Al-AttarProblem statement: Nephrolithiasis or renal stone disease remains a significant health problem in the adult population. Nephrolithiasis is a recurrent disorder prominent in males. It is significant medical and surgical problem because of incidence, recurrence and severe consequences. The present day medical management of nephrolithiasis is either costly or not without side effects. Invasive procedures for the treatment of nephrolithiasis … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 1 · 31 Mar 2010 · 70,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractExposure of Broiler Chickens to a Weak Electromagnetic Field Reduces the Impact of a Simulated, Commercial Eimeria InfectionM.A. Elmusharaf, J.J. Cuppen, H.N.A. Grooten et al.Problem statement: In a previous study, the exposure of broiler chickens to a weak Electromagnetic Field (EMF) reduced the severity of a coccidiosis infection. The birds were infected by gavage into the crop which was not representative for the field situation. Approach: The possible anticoccidial activity of EMF was investigated in broiler chickens with a simulated, commercial coccidiosis infection. There … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 1 · 31 Mar 2010 · 8,282 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of Microsomal Na+/K+ ATPase Activity in the Mechanism of Action of Dopaminergic D2 ReceptorsAbdulrahim Abu-JayyabProblem statement: Our previous research has shown that mitochondrial ATPase may have a role in the action of dopaminergic D2 receptors. It is therefore, thought of interest to investigate the effect of bromocriptine, sulpiride or their combination on the mitochondrial and microsomal ouabain sensitive and ouabain insensitive Na+/K+-ATPase in the liver of rats. Approach: In vivo treatment was carried out … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 6,974 accessesView PDFCite
Research ArticleOpen accessIn the abstractReproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino MiceN. Mehedi, S. Ainad-Tabet, N. Mokrane et al.Problem statement: Tartrazine (FD and C Yellow No. 5) is an orange-colored widely used in food products, drugs and cosmetics. This color has a potential toxicological risk. The current study evaluated the effect of sub-chronic consumption of tartrazine on the male reproductive system. Approach: Tartrazine was administered to adult male mice in drinking water at doses of 0, 0.1, 1 … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 10,415 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment and Validation of High Performance Liquid Chromatographic Method for the Simultaneous Determination of Ceftazidime and Sulbactam in Spiked Plasma and Combined Dosage form-ZydotamMasoom Raza Siddiqui, Abu Tariq, Manu Chaudhary et al.Problem statement: To develop a sensitive method to determine simultaneously ceftizidime and sulbactam in spiked plasma and combined formulation. Approach: In this study an isocratic High performance liquid chromatographic method with UV detection at 230 nm was described for simultaneous determination of Ceftazidime and sulbactam sodium in plasma and combined dosage form. Chromatographic separation of two drugs was achieved on … …American Journal of Applied Sciences, Vol. 6, Issue 10 · 31 Oct 2009 · 7,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntioxidant Research in Asia in the Period from 2000-2008R. R. Hafidh, A. S. Abdulamir, F. Abu Bakar et al.Problem statement: Plant antioxidants are natural plant products that inhibit the adverse effects of the Reactive Oxygen Species (ROS) produced in plants. Thus, antioxidants enable plants to survive. Depending on this principle, human beings started using some plants’ parts to cure from diseases many centuries ago, even before the discovery of microbes or disclosing the etiology of many human diseases. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 8,283 accessesView PDFCite