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Research ArticleOpen accessIn the abstractDetermination of Diloxanide Furoate and Metronidazole in Binary Mixture Using First Derivative of the Ratio-Spectra and High-Performance Liquid Chromatography-UV MethodsNora H. Al-ShaalanTwo methods are presented for simultaneous determination of diloxanide furoate and metronidazole. The first method depends on first derivative of the ratio-spectra by measurements of the amplitudes at 242.5 and 285.5 nm for diloxanide furoate and 225.5 and 300 nm for metrinidazole. Calibration graphs were established for 2-100 μg mL-1 for diloxanide furoate and 1-50 μg mL-1 for metronidazole. In … …American Journal of Applied Sciences, Vol. 4, Issue 2 · 28 Feb 2007 · 7,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractPharmacological Screening of Arceuthobium oxycedri (Dwarf Mistletoe) of Juniper Forest of PakistanMudassir Asrar Zaidi, Ahsan Huda, Sidney A. CrowThe local population of Balochistan, Pakistan considers the Juniperus excelsa an important medicinal plant. The species is facing a grave threat by a parasitic and epiphytic angiosperm, dwarf mistletoe, Arceuthobium oxycedri (DC) M. Bieb (Viscaceae). The methanolic extract of A. oxycedri was studied for its chemical composition and biologically active compounds for the first time. The extract was assayed for … …OnLine Journal of Biological Sciences, Vol. 6, Issue 2 · 31 Dec 2006 · 7,004 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of AP-1 Antagonism in Growth Inhibition of Cervical Cancer Cell Lines by RetinoidsShennan Lu, Doris M. BenbrookRetinoid compounds induce multiple molecular effects that need to be taken into consideration in the development of theses agents as pharmaceuticals for cancer chemoprevention. Inhibition of cancer cell growth by retinoids is thought to occur through at least two mechanisms of transcriptional regulation resulting from direct binding of retinoids to nuclear retinoid receptors (RARs and RXR’s). First, the nuclear receptors … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,862 accessesView PDFCite
Research ArticleOpen accessIn the abstractStability of Neodymium(III) Complexes of 4-Hydroxycoumarins with Anticoagulant ActivityIrena Kostova, Irina NikolovaComplexes of neodymium(III) with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 4-hydroxy-3-[1-(4-chlorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one and 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one were synthesized by mixing of water solutions of neodymium(III) nitrate and the respective ligands, in amounts equal to metal: ligand molar ratio of 1: 3. The complexes were characterized and identified by elemental analysis, conductivity, IR and 1H NMR spectral data. DTA and TGA have been applied to confirm the compositions of … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 2 · 30 Jun 2006 · 7,556 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudy of the Mandibular Glands of Ant Workers Atta sexdens rubropilosa (Forel, 1908) (Hymenoptera: Formicidae) Focusing the Ultrastructural CytochemistryLorena Favaro Pavon, Maria Izabel Camargo MathiasThe mandibular glands of hymenopterans in general are paired structures located on each side of the head. These glands possess an excretory duct located at the internal surface of the mandible articulation, through which these glands release the secretion they produce. The mandibular glands of the minima, media and soldier worker of the ant Atta sexdens rubropilosa were analyzed by … …American Journal of Agricultural and Biological Sciences, Vol. 1, Issue 2 · 30 Jun 2006 · 7,648 accessesView PDFCite
Research ArticleOpen accessIn the abstractPhysical Basis of Magnetic Resonance Spectroscopy and its Application to Central Nervous System DiseasesNicolás Fayed, Salvador Olmos, Humberto Morales, Pedro J. ModregoMagnetic Resonance Spectroscopy is based on the chemical shift property of the atom nuclei when a magnetic field is applied. This technique offers invaluable information about living tissues with special contribution to the diagnosis and prognosis of the central nervous system diseases. Concentration of several metabolites can be assessed in a reproducible manner by means of modern clinical scanners. N-acetyl-aspartate … …American Journal of Applied Sciences, Vol. 3, Issue 5 · 31 May 2006 · 7,858 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntroduction of Three Complementary Technologies into Clinical Medicine: Development of New Diagnostic and Prognostic ParametersGernot P. Tilz, Marco Wiltgen, Ulrike Demel et al.Molecular medicine leads us to understand some diseases at the molecular level. Examples are the analysis of immune complexes and receptor - anti receptor compounds used in clinical medicine. Structural changes of some serum proteins occur in inflammation, neoplasie and autoimmunity. The detection and analysis of such structural modifications may offer a new field for the diagnosis, prognosis and therapy … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,961 accessesView PDFCite
Research ArticleOpen accessIn the abstractNa,K-ATPase α Subunit-like Immunoreactive Proteins in Human Body FluidsJeng-Hsiung F. PengNa,K-ATPase was recently considered a target for breast cancer treatment since its potent inhibitors ouabain and related digitalis compounds that were reported circulating in body fluids before, were found to possess potent anti-breast cancer activity. Based on this finding, it is hypothesized that Na,K-ATPase derivatives could be circulating in the body and potential candidate biomarkers for early disease detection. Western … …American Journal of Immunology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,893 accessesView PDFCite
Research ArticleOpen accessIn the abstractHospital Wastewater Treatment Using an Integrated Anaerobic Aerobic Fixed Film BioreactorA. Rezaee, M. Ansari, A. Khavanin et al.The design and operation of wastewater treatment systems for hospital is a challenge for wastewater engineers. In this study, a pilot-scale system integrated anaerobic-aerobic fixed film reactor for hospital wastewater treatment was constructed and its performance was evaluated. The aim of the study was the elimination of organic compounds and a significant reduction of bacteria. The system had been operated … …American Journal of Environmental Sciences, Vol. 1, Issue 4 · 31 Dec 2005 · 8,150 accessesView PDFCite